DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trap1 and Hsp90ab1

DIOPT Version :9

Sequence 1:	NP_001260726.1	Gene:	Trap1 / 35559	FlyBaseID:	FBgn0026761	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001004082.3	Gene:	Hsp90ab1 / 301252	RGDID:	1303075	Length:	724	Species:	Rattus norvegicus

Alignment Length:	694	Identity:	228/694 - (32%)
Similarity:	358/694 - (51%)	Gaps:	98/694 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 VDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENLAGKDRPLEIR 127
            |:...||||..||:.::..:.||:.|:|:|||||||||||:|.||.||:...:..:||:  |:|.
  Rat    12 VETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKE--LKID 74

  Fly   128 ITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEASSNIIGQFGVG 192
            |..:.....|.:.||||||||.:|::||||||:||:|.|:|.:   |.|    |..::|||||||
  Rat    75 IIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEAL---QAG----ADISMIGQFGVG 132

  Fly   193 FYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPDVELGTRIVLHLKTDCREYADEER 257
            |||:::||.||.|.|:...........|..||.|...:....:..||:::||||.|..||.:|.|
  Rat   133 FYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERR 197

  Fly   258 IKAVIKKYSNFVGSPILL---------------------------------------------NG 277
            :|.|:||:|.|:|.||.|                                             :|
  Rat   198 VKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKEDEEKPKIEDVGSDEEDDSG 262

  Fly   278 K-----------------QANEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNADVPL 325
            |                 :.|:.||:|...|..|::|::.:||:.::|.::......|::.:..|
  Rat   263 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQL 327

  Fly   326 SIHALLYFPEGKP-GLFEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIPLNLS 389
            ...|||:.|...| .|||..:..| .:.||.|:|.|....:.|:|::|.|::|||||||:|||:|
  Rat   328 EFRALLFIPRRAPFDLFENKKKKN-NIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNIS 391

  Fly   390 RELLQNSSLIRKLSSVISTRVIRFLQERSKKQPEEYEAFYRDYGLFLKEGIVTSSDASEKEEIAK 454
            ||:||.|.:::.:...|..:.:....|.::.: |.|:.||..:...||.||  ..|::.:..:::
  Rat   392 REMLQQSKILKVIRKNIVKKCLELFSELAEDK-ENYKKFYEAFSKNLKLGI--HEDSTNRRRLSE 453

  Fly   455 LLRFESSKSETASGRMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELVLFCYEP 519
            |||:.:|:|  .....||.||.:.:...|::|||:...::....:|.:.|.::||...|::..||
  Rat   454 LLRYHTSQS--GDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEP 516

  Fly   520 YDELVLMQLGKFKSKKLVSVEKEMREESKETTATTDFGEGSLLRSELDTLIPWLEEELRGQVIKV 584
            .||..:.||.:|..|.||||.||..|..::........|.   :::.:.|...::|.|..:|.||
  Rat   517 IDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEES---KAKFENLCKLMKEILDKKVEKV 578

  Fly   585 KATTRLDTHPCVITVEEMAAARHFIRTQSHQVPEQNR---FALLQPELEINPKHPIIKKLNKLRE 646
            ..:.||.:.||.|.........:..|....|....|.   :.:.:..|||||.|||::.|.:..|
  Rat   579 TISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAE 643

  Fly   647 SD------KDLAQLIAKQLFANAMVGAGLA-EDPRMLLTNMNTL 683
            :|      |||..|    ||..|::.:|.: |||:   |:.|.:
  Rat   644 ADKNDKAVKDLVVL----LFETALLSSGFSLEDPQ---THSNRI 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trap1	NP_001260726.1	PRK05218	65..689	CDD:235366	227/692 (33%)
		HATPase_c	91..246	CDD:280651	69/154 (45%)
		HSP90	251..688	CDD:278607	145/506 (29%)
Hsp90ab1	NP_001004082.3	Interaction with TP53. /evidence=ECO:0000250\|UniProtKB:P08238	2..527		180/529 (34%)
		Interaction with BIRC2. /evidence=ECO:0000250\|UniProtKB:P08238	2..214		95/210 (45%)
		Interaction with NR3C1. /evidence=ECO:0000250\|UniProtKB:P11499	9..231		97/227 (43%)
		HSP90	14..724	CDD:332554	227/692 (33%)
		Interaction with AHSA1. /evidence=ECO:0000250\|UniProtKB:P08238	215..552		93/342 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..270		2/47 (4%)
		Interaction with NR3C1. /evidence=ECO:0000250\|UniProtKB:P11499	264..608		103/352 (29%)
		Interaction with NR1D1. /evidence=ECO:0000250\|UniProtKB:P11499	620..723		24/68 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..724
		TPR repeat-binding	720..724
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D924636at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820