DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trap1 and enpl-1

DIOPT Version :9

Sequence 1:	NP_001260726.1	Gene:	Trap1 / 35559	FlyBaseID:	FBgn0026761	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001255536.1	Gene:	enpl-1 / 178014	WormBaseID:	WBGene00011480	Length:	760	Species:	Caenorhabditis elegans

Alignment Length:	690	Identity:	215/690 - (31%)
Similarity:	361/690 - (52%)	Gaps:	84/690 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SVVDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENLAGKDRPLE 125
            |..:|||||||..:::.::..|||.:.|:|:|||||||||||:|.|..||: ..|.|. :...:.
Worm    59 SKAEKHEFQAEVNRMMKLIINSLYRNKEIFLRELISNASDALDKIRLLSLT-DPEQLR-ETEEMS 121

  Fly   126 IRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEASSNIIGQFG 190
            ::|..|:....|.|.|||:|||:::|::|||||||||:.:||.::..|  ..||:...::|||||
Worm   122 VKIKADRENRLLHITDTGVGMTRQDLINNLGTIARSGTSEFLSKLMDT--ATSSDQQQDLIGQFG 184

  Fly   191 VGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVP---DVELGTRIVLHLKTDCREY 252
            ||||::|:||::|.|.|:.  .:.....|.:| |.::.|.:.|   .::.||:|.|:||.:..::
Worm   185 VGFYAAFLVADRVVVTTKN--NDDDQYIWESD-SASFTISKDPRGNTLKRGTQITLYLKEEAADF 246

  Fly   253 ADEERIKAVIKKYSNFVGSPILL-----------------------------------------N 276
            .:.:.:|.::.|||.|:...|.|                                         :
Worm   247 LEPDTLKNLVHKYSQFINFDIFLWQSKTEMVEEAVEEEPATTEDGAVEEEKEEKKTKKVEKTTWD 311

  Fly   277 GKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNADVPLSIHALLYFPEGKPG-L 340
            .::.|.:||:|:.:|..:.::::..||:.|:...:.|...:|::|:..:|..::||.|:..|. :
Worm   312 WEKVNNVKPIWMRKPNQVEEDEYKQFYKSITKDSEEPLSHVHFSAEGEVSFRSILYVPKKSPNDM 376

  Fly   341 FEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIPLNLSRELLQNSSLIRKLSSV 405
            |:........:.||.|:|.|......:|||:|.|::|:|||:|:|||:|||.||.    .||..|
Worm   377 FQNYGKVIENIKLYVRRVFITDDFADMLPKYLSFIRGIVDSDDLPLNVSRENLQQ----HKLLKV 437

  Fly   406 ISTRVIRFLQERSKK-QPEEYEAFYRDYGLFLKEGIVTSSDASEKEEIAKLLRFESSKSETASGR 469
            |..:::|.:.:..|| ...:::.|:.::...:|.|::  .|.|.:..:||||||:||..  |...
Worm   438 IKKKLVRKVLDMLKKLDGAQFDDFWSEFSTNIKLGVM--EDPSNRMRLAKLLRFQSSND--ADKT 498

  Fly   470 MSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELVLFCYEPYDELVLMQLGKFKSK 534
            .:|..|...:..:|..|||:|..:|...|:||:.|.|..:...|||..|..||..:..:.:::||
Worm   499 TTLAAYVERMKEKQDAIYYMAGTSRKEVETSPFVERLIAKGYEVLFLTEAVDEYCIQAMPEYESK 563

  Fly   535 KLVSVEKEMREESKETTATTDFGEGSL-----LRSELDTLIPWLEE-ELRGQVIKVKATTRLDTH 593
            |..:|.||        ..|.|.||.:.     |..|...|..||:| .|:..:.|...:.||...
Worm   564 KFQNVAKE--------GVTIDDGEKAKEAHKGLEEEFKPLTDWLKETALKDLIEKAVVSQRLVKS 620

  Fly   594 PCVITVEEMAAARHFIRTQSHQV------PEQNRFALLQPELEINPKHPIIKK-LNKLRESDKD- 650
            |..:.......:.:..|....|.      |.|:.:|..:...||||:||:||: |.::..|::|
Worm   621 PSALVASSYGWSGNMERIMKSQAYAKAKDPTQDFYATQKKTFEINPRHPVIKELLKRVTASEEDT 685

  Fly   651 LAQLIAKQLFANAMVGAGLA-EDPRMLLTNMNTLLSRALE 689
            .|...||.||..|.:.:|.: :|.......:..:|.::|:
Worm   686 TAASTAKLLFETATLRSGFSLQDQVGFADRIEAVLRQSLD 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trap1	NP_001260726.1	PRK05218	65..689	CDD:235366	213/684 (31%)
		HATPase_c	91..246	CDD:280651	66/157 (42%)
		HSP90	251..688	CDD:278607	133/494 (27%)
enpl-1	NP_001255536.1	PRK05218	59..724	CDD:235366	214/687 (31%)
		HATPase_c	84..242	CDD:214643	70/164 (43%)
		HSP90	245..735	CDD:278607	134/497 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D924636at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920