DRSC/TRiP Functional Genomics Resources

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Protein Alignment Trap1 and Hsp90aa1

DIOPT Version :9

Sequence 1:NP_001260726.1 Gene:Trap1 / 35559 FlyBaseID:FBgn0026761 Length:691 Species:Drosophila melanogaster
Sequence 2:NP_034610.1 Gene:Hsp90aa1 / 15519 MGIID:96250 Length:733 Species:Mus musculus


Alignment Length:717 Identity:227/717 - (31%)
Similarity:357/717 - (49%) Gaps:120/717 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 TETKQASGSVVDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENL 117
            |:.:......|:...||||..||:.::..:.||:.|:|:||||||:||||:|.||.||:...:..
Mouse     7 TQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLD 71

  Fly   118 AGKDRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEAS 182
            :||:  |.|.:...|....|.|.||||||||.:|::||||||:||:|.|:|.:   |.|    |.
Mouse    72 SGKE--LHINLIPSKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEAL---QAG----AD 127

  Fly   183 SNIIGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPDVELGTRIVLHLKT 247
            .::||||||||||:::||.||.|.|:...........|..||.|...:....:..||:::||||.
Mouse   128 ISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKE 192

  Fly   248 DCREYADEERIKAVIKKYSNFVGSPILL------------------------------------- 275
            |..||.:|.|||.::||:|.|:|.||.|                                     
Mouse   193 DQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEKEKEEKESDDKPE 257

  Fly   276 -----------------------------NGKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFD 311
                                         :.::.|:.||:|...|..|:.|::.:||:.::|.::
Mouse   258 IEDVGSDEEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWE 322

  Fly   312 VPRFTLHYNADVPLSIHALLYFPEGKP-GLFEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFV 375
            ......|::.:..|...|||:.|...| .||| :|.....:.||.|:|.|....|.|:|::|.|:
Mouse   323 EHLAVKHFSVEGQLEFRALLFVPRRAPFDLFE-NRKKKNNIKLYVRRVFIMDNCEELIPEYLNFI 386

  Fly   376 KGVVDSEDIPLNLSRELLQNSSLIRKLSSVISTRVIRFLQERSKKQPEEYEAFYRDYGLFLKEGI 440
            :|||||||:|||:|||:||.|.:::.:...:..:.:....|.::.: |.|:.||..:...:|.||
Mouse   387 RGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDK-ENYKKFYEQFSKNIKLGI 450

  Fly   441 VTSSDASEKEEIAKLLRFESSKSETASG--RMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYY 503
              ..|:..::::::|||:.:|    |||  .:||::|...:...|::||::....:....:|.:.
Mouse   451 --HEDSQNRKKLSELLRYYTS----ASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFV 509

  Fly   504 ESLKKRNELVLFCYEPYDELVLMQLGKFKSKKLVSVEKE-------MREESKETTATTDFGEGSL 561
            |.|:|....|::..||.||..:.||.:|:.|.||||.||       ..|:.|:....|.|     
Mouse   510 ERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKF----- 569

  Fly   562 LRSELDTLIPWLEEELRGQVIKVKATTRLDTHPCVITVEEMAAARHFIRTQSHQVPEQNR---FA 623
                 :.|...:::.|..:|.||..:.||.|.||.|.........:..|....|....|.   :.
Mouse   570 -----ENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYM 629

  Fly   624 LLQPELEINPKHPIIKKLNKLRESD------KDLAQLIAKQLFANAMVGAGLA-EDPRMLLTNMN 681
            ..:..|||||.|.||:.|.:..|:|      |||..|    |:..|::.:|.: |||:   |:.|
Mouse   630 AAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVIL----LYETALLSSGFSLEDPQ---THAN 687

  Fly   682 TL 683
            .:
Mouse   688 RI 689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Trap1NP_001260726.1 PRK05218 65..689 CDD:235366 225/705 (32%)
HATPase_c 91..246 CDD:280651 69/154 (45%)
HSP90 251..688 CDD:278607 143/519 (28%)
Hsp90aa1NP_034610.1 Interaction with NR3C1. /evidence=ECO:0000269|PubMed:27686098 9..236 97/235 (41%)
PTZ00272 18..733 CDD:240341 225/706 (32%)
HATPase_c 40..191 CDD:214643 71/159 (45%)
HSP90 196..723 CDD:278607 143/519 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..279 0/53 (0%)
Interaction with NR3C1. /evidence=ECO:0000269|PubMed:27686098 272..617 104/362 (29%)
Interaction with FLCN and FNIP1. /evidence=ECO:0000250|UniProtKB:P07900 285..733 129/430 (30%)
Interaction with FNIP2 and TSC1. /evidence=ECO:0000250|UniProtKB:P07900 285..621 105/353 (30%)
Interaction with NR1D1. /evidence=ECO:0000269|PubMed:27686098 629..732 23/68 (34%)
Required for homodimerization. /evidence=ECO:0000250|UniProtKB:P07900 683..733 2/10 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..733
TPR repeat-binding. /evidence=ECO:0000250|UniProtKB:P07900 724..733
Essential for interaction with SMYD3, TSC1 and STIP1/HOP. /evidence=ECO:0000250|UniProtKB:P07900 729..733
Essential for interaction with SGTA and TTC1. /evidence=ECO:0000250|UniProtKB:P07900 730..733
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0326
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D924636at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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