Protein Alignment Trap1 and Hsp90aa1

DIOPT Version :10

• Sequence 1: NP_477439.2
• Gene: Trap1 / 35559
• FlyBaseID: FBgn0026761
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_034610.1
• Gene: Hsp90aa1 / 15519
• MGIID: 96250
• Length: 733
• Species: Mus musculus
• Alignment Length: 717
• Identity: 227/717 - (31%)
• Similarity: 357/717 - (49%)
• Gaps: 120/717 - (16%)

  Fly    53 TETKQASGSVVDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENL 117
            |:.:......|:...||||..||:.::..:.||:.|:|:||||||:||||:|.||.||:...:..
Mouse     7 TQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLD 71

  Fly   118 AGKDRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEAS 182
            :||:  |.|.:...|....|.|.||||||||.:|::||||||:||:|.|:|.:   |.|    |.
Mouse    72 SGKE--LHINLIPSKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEAL---QAG----AD 127

  Fly   183 SNIIGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPDVELGTRIVLHLKT 247
            .::||||||||||:::||.||.|.|:...........|..||.|...:....:..||:::||||.
Mouse   128 ISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKE 192

  Fly   248 DCREYADEERIKAVIKKYSNFVGSPILL------------------------------------- 275
            |..||.:|.|||.::||:|.|:|.||.|
Mouse   193 DQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEKEKEEKESDDKPE 257

  Fly   276 -----------------------------NGKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFD 311
                                         :.::.|:.||:|...|..|:.|::.:||:.::|.::
Mouse   258 IEDVGSDEEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWE 322

  Fly   312 VPRFTLHYNADVPLSIHALLYFPEGKP-GLFEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFV 375
            ......|::.:..|...|||:.|...| .||| :|.....:.||.|:|.|....|.|:|::|.|:
Mouse   323 EHLAVKHFSVEGQLEFRALLFVPRRAPFDLFE-NRKKKNNIKLYVRRVFIMDNCEELIPEYLNFI 386

  Fly   376 KGVVDSEDIPLNLSRELLQNSSLIRKLSSVISTRVIRFLQERSKKQPEEYEAFYRDYGLFLKEGI 440
            :|||||||:|||:|||:||.|.:::.:...:..:.:....|.::.: |.|:.||..:...:|.||
Mouse   387 RGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDK-ENYKKFYEQFSKNIKLGI 450

  Fly   441 VTSSDASEKEEIAKLLRFESSKSETASG--RMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYY 503
              ..|:..::::::|||:.:|    |||  .:||::|...:...|::||::....:....:|.:.
Mouse   451 --HEDSQNRKKLSELLRYYTS----ASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFV 509

  Fly   504 ESLKKRNELVLFCYEPYDELVLMQLGKFKSKKLVSVEKE-------MREESKETTATTDFGEGSL 561
            |.|:|....|::..||.||..:.||.:|:.|.||||.||       ..|:.|:....|.|
Mouse   510 ERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKF----- 569

  Fly   562 LRSELDTLIPWLEEELRGQVIKVKATTRLDTHPCVITVEEMAAARHFIRTQSHQVPEQNR---FA 623
                 :.|...:::.|..:|.||..:.||.|.||.|.........:..|....|....|.   :.
Mouse   570 -----ENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYM 629

  Fly   624 LLQPELEINPKHPIIKKLNKLRESD------KDLAQLIAKQLFANAMVGAGLA-EDPRMLLTNMN 681
            ..:..|||||.|.||:.|.:..|:|      |||..|    |:..|::.:|.: |||:   |:.|
Mouse   630 AAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVIL----LYETALLSSGFSLEDPQ---THAN 687

  Fly   682 TL 683
            .:
Mouse   688 RI 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trap1	NP_477439.2	HtpG	65..689	CDD:440095	225/705 (32%)
Hsp90aa1	NP_034610.1	Interaction with NR3C1. /evidence=ECO:0000269|PubMed:27686098	9..236		97/235 (41%)
		HSP90	18..733	CDD:481033	225/706 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..279		0/53 (0%)
		Interaction with NR3C1. /evidence=ECO:0000269|PubMed:27686098	272..617		104/362 (29%)
		Interaction with FLCN and FNIP1. /evidence=ECO:0000250|UniProtKB:P07900	285..733		129/430 (30%)
		Interaction with FNIP2 and TSC1. /evidence=ECO:0000250|UniProtKB:P07900	285..621		105/353 (30%)
		Interaction with NR1D1. /evidence=ECO:0000269|PubMed:27686098	629..732		23/68 (34%)
		Required for homodimerization. /evidence=ECO:0000250|UniProtKB:P07900	683..733		2/10 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..733
		TPR repeat-binding. /evidence=ECO:0000250|UniProtKB:P07900	724..733
		Essential for interaction with SMYD3, TSC1 and STIP1/HOP. /evidence=ECO:0000250|UniProtKB:P07900	729..733
		Essential for interaction with SGTA and TTC1. /evidence=ECO:0000250|UniProtKB:P07900	730..733