Protein Alignment Trap1 and TRAP1

DIOPT Version :10

• Sequence 1: NP_477439.2
• Gene: Trap1 / 35559
• FlyBaseID: FBgn0026761
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_057376.2
• Gene: TRAP1 / 10131
• HGNCID: 16264
• Length: 704
• Species: Homo sapiens
• Alignment Length: 649
• Identity: 342/649 - (52%)
• Similarity: 467/649 - (71%)
• Gaps: 30/649 - (4%)

  Fly    52 STETKQASGSVVDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGEN 116
            |||:.|.|.|   ||||||||::|||||||||||:.|||:|||||||||||||.|: .|.:.|:.
Human    77 STESVQGSTS---KHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRH-KLVSDGQA 137

  Fly   117 LAGKDRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEA 181
            |.    .:||.:.|:.....:.|||||||||:||||||||||||||||.||:.::.     .:||
Human   138 LP----EMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLDALQN-----QAEA 193

  Fly   182 SSNIIGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPDVELGTRIVLHLK 246
            ||.|||||||||||:|:||::|||::|:|.|.:.|.:|.:||||.:||.|...|..||:|::|||
Human   194 SSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLK 258

  Fly   247 TDCREYADEERIKAVIKKYSNFVGSPILLNGKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFD 311
            :||:|::.|.|::.|:.||||||..|:.|||::.|.::.:|:::|:.:.:.||.:|||:::.:.|
Human   259 SDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHD 323

  Fly   312 VPRFTLHYNADVPLSIHALLYFPEGKPGLFEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVK 376
            .||:||||..|.||:|.::.|.|:.||.:|::||:..:.||||:||||||:|...:|||||||::
Human   324 KPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIR 388

  Fly   377 GVVDSEDIPLNLSRELLQNSSLIRKLSSVISTRVIRFLQERSKKQPEEYEAFYRDYGLFLKEGIV 441
            ||||||||||||||||||.|:|||||..|:..|:|:|..::|||..|:|..|:.|||||::||||
Human   389 GVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIV 453

  Fly   442 TSSDASEKEEIAKLLRFESSKSETASGRM-SLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYES 505
            |:::...||:||||||:||  |...||:: ||.||.:.:.|..:|||||.||||.|||.|||||:
Human   454 TATEQEVKEDIAKLLRYES--SALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEA 516

  Fly   506 LKKRNELVLFCYEPYDELVLMQLGKFKSKKLVSVE--------KEMREESKETTATTDFGEGSLL 562
            :||::..||||:|.:|||.|:.|.:|..|||:|||        ||.:.|.:...|.      .|.
Human   517 MKKKDTEVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDRSPAAE------CLS 575

  Fly   563 RSELDTLIPWLEEELRGQVIKVKATTRLDTHPCVITVEEMAAARHFIRTQSHQVPEQNRFALLQP 627
            ..|.:.|:.|:...|..:|..||.|.||||||.::||.||.|||||:|.|.....::.|..||||
Human   576 EKETEELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQP 640

  Fly   628 ELEINPKHPIIKKLNKLRESDKDLAQLIAKQLFANAMVGAGLAEDPRMLLTNMNTLLSRALEKY 691
            .|||||:|.:|||||:||.|:..||||:..|::.|||:.|||.:|||.::..:|.||.:|||::
Human   641 TLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKALERH 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trap1	NP_477439.2	HtpG	65..689	CDD:440095	334/632 (53%)
TRAP1	NP_057376.2	PRK05218	87..702	CDD:235366	334/632 (53%)