Protein Alignment jing and ZIC3

DIOPT Version :10

• Sequence 1: NP_001097200.1
• Gene: jing / 35555
• FlyBaseID: FBgn0086655
• Length: 1744
• Species: Drosophila melanogaster
• Sequence 2: NP_003404.1
• Gene: ZIC3 / 7547
• HGNCID: 12874
• Length: 467
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 98/459 - (21%)
• Similarity: 149/459 - (32%)
• Gaps: 166/459 - (36%)

  Fly  1161 PAPSPSPSASPSGLGSPSPAASNLSASSRRAASQTDMLSELVTSSCISSGGDDCSQATDSPPMPA 1225
            |.....|:..|:|:|. :|...:..|::..||:....||...... :|||
Human    22 PRHHEMPNREPAGMGL-NPFGDSTHAAAAAAAAAAFKLSPAAAHD-LSSG--------------- 69

  Fly  1226 LPLAKSEDATTPISTVSGGSSSGSSNYDEEDDKSVASLETHQTHKRLRDLPTPESGIGGSLSNSE 1290
                 ...|.||       ..||.:|          :|..|..|.......:.....||:.  |.
Human    70 -----QSSAFTP-------QGSGYAN----------ALGHHHHHHHHHHHTSQVPSYGGAA--SA 110

  Fly  1291 SSNSIADAISSKSASVGPPTTAASSASSSASDSNSLASNAPSPASPEDCSAAPS----PACSAST 1351
            :.||..:.:..:.:|      ..|.|:|........|.:|.|..:|......||    |......
Human   111 AFNSTREFLFRQRSS------GLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQG 169

  Fly  1352 TGSIPPSTVVDIAMV------EATSKSLPKSAISPILSQPKTIRFPAGA---------------- 1394
            .|...|:..||...|      |...::.|   ..|:.| |:|..:.|||
Human   170 AGHPSPTGHVDNNQVHLGLRGELFGRADP---YRPVAS-PRTDPYAAGAQFPNYSPMNMNMGVNV 230

  Fly  1395 ------GASGK-----------------------------------------------GGKRHDG 1406
                  ||..:                                               |.::::.
Human   231 AAHHGPGAFFRYMRQPIKQELSCKWIDEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNH 295

  Fly  1407 VCYWDKC---NKKHESNSKLLDHMQTHHVNTQTGPFACLWVGC-KVYNKESCSRRWLERHVLSHG 1467
            ||||::|   .|..::..||::|::.|   |...||.|.:.|| |::.:...    |:.|..:|.
Human   296 VCYWEECPREGKSFKAKYKLVNHIRVH---TGEKPFPCPFPGCGKIFARSEN----LKIHKRTHT 353

  Fly  1468 GSKQFKCIVEGCGLRFGSQLALQKHVNNHFNATDNARESTSKRTSDPPV-----------PKQLR 1521
            |.|.|||..|||..||.:....:||::.|              |||.|.           |..||
Human   354 GEKPFKCEFEGCDRRFANSSDRKKHMHVH--------------TSDKPYICKVCDKSYTHPSSLR 404

  Fly  1522 KNGK 1525
            |:.|
Human   405 KHMK 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jing	NP_001097200.1	C2H2 Zn finger	1411..1430	CDD:275368	5/21 (24%)
		C2H2 Zn finger	1441..1466	CDD:275368	6/25 (24%)
		C2H2 Zn finger	1474..1496	CDD:275368	8/21 (38%)
ZIC3	NP_003404.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..107		13/77 (17%)
		zf_ZIC	245..290	CDD:436441	0/44 (0%)
		Nuclear localization signal	297..322		8/24 (33%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		SFP1	<324..408	CDD:227516	30/101 (30%)
		C2H2 Zn finger	330..352	CDD:275368	6/25 (24%)
		Nuclear localization signal	330..352		6/25 (24%)
		C2H2 Zn finger	360..382	CDD:275368	8/21 (38%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..467		3/5 (60%)