Protein Alignment jing and GLI1

DIOPT Version :10

• Sequence 1: NP_001097200.1
• Gene: jing / 35555
• FlyBaseID: FBgn0086655
• Length: 1744
• Species: Drosophila melanogaster
• Sequence 2: NP_005260.1
• Gene: GLI1 / 2735
• HGNCID: 4317
• Length: 1106
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 120/603 - (19%)
• Similarity: 189/603 - (31%)
• Gaps: 221/603 - (36%)

  Fly  1161 PAPSP-SPSASPSGL-GSPSPAASNLSASSRRAASQTDMLSELVTSSCISSGGDDCSQATDSP-- 1221
            |.||. :||....|| |.|....:||.:.........:      |:||           |:.|
Human    21 PLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARE------TNSC-----------TEGPLF 68

  Fly  1222 --PMPALPLAKS--------EDATTPISTVSGGSSSGSSNYDEEDDKSVASLETHQTHKRLRDLP 1276
              |..|:.|.|.        .||:..:.||...|.|          ..||.:.:..|
Human    69 SSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPS----------SLVAFINSRCT-------- 115

  Fly  1277 TPESGIGGSLSNSESSNSIADAISSKSASVGPPTTAASSASSSASDSNSLASNAPS----PASPE 1337
            :|    |||..:.        :|.:.|.|:|.|           :..|.....:||    |..|.
Human   116 SP----GGSYGHL--------SIGTMSPSLGFP-----------AQMNHQKGPSPSFGVQPCGPH 157

  Fly  1338 DC----------SAAPSPACSASTTGSIPPSTVVDIAMVEATSKSLPKSAISPILSQPKT--IRF 1390
            |.          |..|.|.|...:          ::.|:....:..|   :...:|.|.:  |:.
Human   158 DSARGGMIPHPQSRGPFPTCQLKS----------ELDMLVGKCREEP---LEGDMSSPNSTGIQD 209

  Fly  1391 PAGAGASGKGG-----KR-----HDGVCYWDKCNKKHESNSKLLDHMQTHHVNTQTGPFACLWVG 1445
            |......|:..     ||     ::..|.||.|:::.:|..:|:.|:.:.|::.:...|.|.|.|
Human   210 PLLGMLDGREDLEREEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGG 274

  Fly  1446 CKVYNKESCSRRWLERHVLSHGGSKQFKCIVEGCGLRFGSQLALQKHVNNH-------------- 1496
            |....:...::..|..|:..|.|.|..||..|||...:.....|:.|:.:|
Human   275 CSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCS 339

  Fly  1497 ---FNATDNARESTSKRTSDPPV-------------PKQLRKNGKKL---------RYRRQPFSA 1536
               .||:|.|:......:::.|.             |..|||:.|.:         |:|.
Human   340 KAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRG----- 399

  Fly  1537 RMFDFFDTGIMEGLQHRLRQISTLTNGAQAIEFQGQCMMRRRNSQGGYECFVRWSPREIISDEWL 1601
                       :|...|...|||:.              .:|..:||        |....|...:
Human   400 -----------DGPLPRAPSISTVE--------------PKREREGG--------PIREESRLTV 431

  Fly  1602 PECLNRTRQHTKVLHIKQMRPAEKTRVDSLLSTAFRLRYDSHLFADDYNVNEQQVGEASGSD--C 1664
            ||              ..|:|.......|..|:                 :....|.|:.:|  .
Human   432 PE--------------GAMKPQPSPGAQSSCSS-----------------DHSPAGSAANTDSGV 465

  Fly  1665 DEDGDGDQEEEDLEDQDE 1682
            :..|:.....|||...||
Human   466 EMTGNAGGSTEDLSSLDE 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jing	NP_001097200.1	C2H2 Zn finger	1411..1430	CDD:275368	5/18 (28%)
		C2H2 Zn finger	1441..1466	CDD:275368	6/24 (25%)
		C2H2 Zn finger	1474..1496	CDD:275368	6/21 (29%)
GLI1	NP_005260.1	Interaction with SUFU. /evidence=ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597	120..124		1/3 (33%)
		FOXP-CC	237..>265	CDD:465036	8/27 (30%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:8378770	283..291		1/7 (14%)
		SFP1	<297..387	CDD:227516	20/89 (22%)
		C2H2 Zn finger	303..325	CDD:275368	6/21 (29%)
		C2H2 Zn finger	333..356	CDD:275368	4/22 (18%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:8378770	345..350		2/4 (50%)
		C2H2 Zn finger	364..385	CDD:275368	4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..485		32/178 (18%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:8378770	375..381		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	516..580
		PHA03247	<562..1081	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..792
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	817..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..942
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1054..1087
		SNAG domain. /evidence=ECO:0000250	1..20