DRSC/TRiP Functional Genomics Resources

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Protein Alignment jing and AEBP2

DIOPT Version :9

Sequence 1:NP_001097200.1 Gene:jing / 35555 FlyBaseID:FBgn0086655 Length:1744 Species:Drosophila melanogaster
Sequence 2:NP_001107648.1 Gene:AEBP2 / 121536 HGNCID:24051 Length:517 Species:Homo sapiens


Alignment Length:639 Identity:153/639 - (23%)
Similarity:236/639 - (36%) Gaps:188/639 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1011 LANSAPDLFDLVKNSKLVAKVSQPLTPLPFSSPSSSSNGSHGSHGMRSSPALSTSNSCTLSAFSK 1075
            :|.:..|:.||.:.|:        |:|||..||.|::.|       |:.|.......        
Human     1 MAAAITDMADLEELSR--------LSPLPPGSPGSAARG-------RAEPPEEEEEE-------- 42

  Fly  1076 IKVETTELASQT------------------GSLTSSSIPTISLKPQSFAGQLPKREPESETDTLK 1122
             :.|..|..::.                  |.:......|:|......|.|..:.|.|.|.|..:
Human    43 -EEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEE 106

  Fly  1123 HDLLPDCTNSNSNSNSCSSSTYSHSVSSAADLSLEASTPAPSPSPSASPSGLGSPSPAASNLSAS 1187
            .|                                           .:|.||.|....:|.:|..|
Human   107 ED-------------------------------------------ESSSSGGGEEESSAESLVGS 128

  Fly  1188 SRRAAS-QTDMLSELVTSSCISSGGDDCSQATDSPPMPALPLAKSEDATTPISTVSGGSSSGSSN 1251
            |..::| :|..||....||  |||..|..:..:.|..|.                  ||..|   
Human   129 SGGSSSDETRSLSPGAASS--SSGDGDGKEGLEEPKGPR------------------GSQGG--- 170

  Fly  1252 YDEEDDKSVASLETHQTHKRLRDLPTPESGIGGSLSNSESSNSIADAISSKSASVGPPTTAASSA 1316
                                         |.|||.|:|         :.|.....|..|....|:
Human   171 -----------------------------GGGGSSSSS---------VVSSGGDEGYGTGGGGSS 197

  Fly  1317 SSSASDSNSLASNAPSPASPEDCSAAPSPACSASTTGSIPPSTVVDIAMVEATSKSLPKSAISPI 1381
            ::|.....||           :.|:...|.....:..|| .||::|:           .|.||..
Human   198 ATSGGRRGSL-----------EMSSDGEPLSRMDSEDSI-SSTIMDV-----------DSTISSG 239

  Fly  1382 LSQPKTIRFPAGAGASGKGGKRHDGVCYWDKCNKKHESNSKLLDHMQTHHVNTQT-GPFACLWVG 1445
            .|.|..:.   |.|::....|.....|.||:|.....|:..|.||:::.||:.|. |.|.|||.|
Human   240 RSTPAMMN---GQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKG 301

  Fly  1446 CKVYNKESCSRRWLERHVLSHGGSKQFKCIVEGCGLRFGSQLALQKHVNNHFNATDNARESTSKR 1510
            |||||..|.|:.||:||:|:|.|.|.|||:|.||...|.||..|.:||..||:..::::.|:..:
Human   302 CKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPK 366

  Fly  1511 TSDPPVPKQLRKNGKKLRYRRQPFSARMFDFFDTGIMEGLQHRL------RQISTLTNGAQAIEF 1569
            ..:....|......:||:.:|:....|..||||...::.::||.      ..|.:|..| .::.|
Human   367 AKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKG-HSVVF 430

  Fly  1570 QGQCMMRRRNSQGGYECFVRWSPREIISDEWLPECLNRTRQH---TKVLHIKQM 1620
            ....:.:|:...|..:..:.|.|.:|:.|.|    :|.:.:|   |||:|:.::
Human   431 HSTVIAKRKEDSGKIKLLLHWMPEDILPDVW----VNESERHQLKTKVVHLSKL 480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jingNP_001097200.1 C2H2 Zn finger 1411..1430 CDD:275368 6/18 (33%)
C2H2 Zn finger 1441..1466 CDD:275368 16/24 (67%)
C2H2 Zn finger 1474..1496 CDD:275368 10/21 (48%)
AEBP2NP_001107648.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..229 68/367 (19%)
Interaction with RBBP4 209..294 26/99 (26%)
COG5048 <215..>339 CDD:227381 52/138 (38%)
C2H2 Zn finger 266..286 CDD:275368 6/19 (32%)
C2H2 Zn finger 297..322 CDD:275368 16/24 (67%)
C2H2 Zn finger 330..352 CDD:275368 10/21 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 352..394 7/41 (17%)
Interaction with SUZ12. /evidence=ECO:0000269|PubMed:29499137 407..478 19/75 (25%)
Important for nucleosome binding activity of the PRC2 complex. /evidence=ECO:0000269|PubMed:29499137 495..517
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BE0S
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0008420
OrthoInspector 1 1.000 - - oto89013
orthoMCL 1 0.900 - - OOG6_108693
Panther 1 1.100 - - LDO PTHR46541
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
76.770

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