DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pld and PGS1

DIOPT Version :9

Sequence 1:	NP_001137610.1	Gene:	Pld / 35554	FlyBaseID:	FBgn0286511	Length:	1364	Species:	Drosophila melanogaster
Sequence 2:	NP_009923.2	Gene:	PGS1 / 850352	SGDID:	S000000510	Length:	521	Species:	Saccharomyces cerevisiae

Alignment Length:	532	Identity:	88/532 - (16%)
Similarity:	170/532 - (31%)	Gaps:	165/532 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   761 SAFG--------SRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRLLIPSTLVSSPGE 817
            |.||        |.:.:....:...|||......|.:....::.|.|...:|:.|.|..:   |:
Yeast    36 SPFGNYLNTITKSLQQNLQTCFHFQAKEIDIIESPSQFYDLLKTKILNSQNRIFIASLYL---GK 97

  Fly   818 TPAESGIALEGMKLNTPEMERKNVLDRLKNNAMKGARMGKDFMHRLTATETEEK-SAEVYTIESE 881
            :..|....:.......|:::...:||.|:......:......:..|.|....|: ...:|...:.
Yeast    98 SETELVDCISQALTKNPKLKVSFLLDGLRGTRELPSACSATLLSSLVAKYGSERVDCRLYKTPAY 162

  Fly   882 EATDHEV---NLNMASGGQEVAITTSSTQILSEFCG---------QAKYWF--GKDYSNFILKDW 932
            ......:   ..|...|.|.:.|.....:::.....         |.:|:.  .:::||:..|..
Yeast   163 HGWKKVLVPKRFNEGLGLQHMKIYGFDNEVILSGANLSNDYFTNRQDRYYLFKSRNFSNYYFKLH 227

  Fly   933 MNLNS-------PFVD----IIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNAMKLEKLRD 986
            ..::|       |.||    ||         |.|....|..|..:   |.|::..:.:....|:.
Yeast   228 QLISSFSYQIIKPMVDGSINII---------WPDSNPTVEPTKNK---RLFLREASQLLDGFLKS 280

  Fly   987 N-------------------TRFPYLMPKSYHQVRLNPNIQQNRQQRVTCQLLRSVS----AW-- 1026
            :                   ::|..|.|| |:        .::.::|....||.:::    :|
Yeast   281 SKQSLPITAVGQFSTLVYPISQFTPLFPK-YN--------DKSTEKRTILSLLSTITSNAISWTF 336

  Fly  1027 SCGF------IEADLVEQSIHDAYIQTITKAQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGET 1085
            :.|:      |:|.|:...:.:|.:.|.:.      ..|.|:.:..:...:||||    ..:.:.
Yeast   337 TAGYFNILPDIKAKLLATPVAEANVITASP------FANGFYQSKGVSSNLPGAY----LYLSKK 391

  Fly  1086 LFKRIVRAHKERKPFRVYVIMPLLPGFEGDVGGSTGIAVRAITHWNYASISRGRTSILTRLQEAG 1150
            ..:.:.|..::.                                           :|..|..:.|
Yeast   392 FLQDVCRYRQDH-------------------------------------------AITLREWQRG 413

  Fly  1151 IANPENYISFH------SLRNHSFLNN-TPITELIYVHSKLLIADDRVVICGSANINDRSMIGKR 1208
            :.|..|..|:|      |.|:.:..|| .|.                :.:.||:|...|:.....
Yeast   414 VVNKPNGWSYHAKGIWLSARDKNDANNWKPF----------------ITVIGSSNYTRRAYSLDL 462

  Fly  1209 DSEIAAILMDEE 1220
            :|....|..|||
Yeast   463 ESNALIITRDEE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805
		PH_PLD	419..564	CDD:269956
		PLDc_vPLD1_2_yPLD_like_1	590..734	CDD:197236
		PLDc_vPLD1_2_yPLD_like_2	1032..1220	CDD:197239	30/194 (15%)
PGS1	NP_009923.2	PLDc_PGS1_euk_1	64..230	CDD:197233	25/168 (15%)
PGS1	NP_009923.2	PLDc_PGS1_euk_2	295..498	CDD:197235	43/258 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1502
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900