DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pld and si:ch211-168k14.2

DIOPT Version :9

Sequence 1:	NP_001137610.1	Gene:	Pld / 35554	FlyBaseID:	FBgn0286511	Length:	1364	Species:	Drosophila melanogaster
Sequence 2:	XP_017213317.1	Gene:	si:ch211-168k14.2 / 799278	ZFINID:	ZDB-GENE-070912-149	Length:	1097	Species:	Danio rerio

Alignment Length:	1250	Identity:	486/1250 - (38%)
Similarity:	672/1250 - (53%)	Gaps:	222/1250 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 KPVLVERKET--------------DDDEEEFD-----DEENNSVVLRHEIPFTSIYGPSVKFNSF 222
            :|..:||.|:              .||.||.|     |..:..::....|.|.:||. .:.|.|.
Zfish     8 RPPKLERLESVMSKFSGSLDQDVLQDDPEELDLSGQTDLCSGELLESRNISFQAIYN-FLPFKSL 71

  Fly   223 QRKVFIPGREIHVRIVDTERSVTTHLLNPNLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRTS 287
            :..:|:....|.|::.:.||..::.:|||||||:||:||.|||.||||:|||.:|||:|..||..
Zfish    72 EGVIFLEEVPILVQVTEVERFTSSRVLNPNLYTVELSHGDFKWKIKRRFKHFQALHQELLKFRAL 136

  Fly   288 LNIPFPSRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAMA 352
            |.||.|||.|...|.:.|.
Zfish   137 LKIPLPSRIHSVNRRSFKG---------------------------------------------- 155

  Fly   353 MISPNHSSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNLLNISL 417
                                 ||:....::|..|.||::||..|.|..|..||||||.|:|...|
Zfish   156 ---------------------RKRFHGERIPTLPRRPDALVREEQLISRKMQLEDYLRNVLKKPL 199

  Fly   418 YRSHHETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTRPGQAGCNFFGCFQKNCCVRCNYFC-S 481
            ||:|..||.|:|||.:||:..:|.||.||:|.|::|       |..|..|          |:| |
Zfish   200 YRTHPATLEFLEVSQISFIQDLGPKGIEGLIFKKSG-------GNTFPVC----------YWCGS 247

  Fly   482 DVVCGTWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHIVL 546
            :.||..|..||..||::...|:||.||.:..|||:|:||.:..|..:||:|.|:.:....|.:.:
Zfish   248 NSVCYRWSKRWLVVKDSFVLYMRPEDGQVGTVILYDKGFHIKIGALETGVRHGVTIENLCRALTI 312

  Fly   547 KCWTRRKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAAL 611
            ||.|.|:.:.|...:.:.:..:.:||...|.|.||.|:|.||.|.|:|:.|.|..|:||.||.|.
Zfish   313 KCSTYRQARWWGHSIDDFSQMFGQDFLRENRHGSFTPVRENTTAKWFVNAAGYFDAIADALEGAK 377

  Fly   612 EEIYIADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKSTL 676
            |||:|..|||||||::|||.:||:.||||.:|.|||||||::||.||||||:.:|:||.|:|.||
Zfish   378 EEIFITAWWLSPEIFLKRPVVDGNMWRLDHVLKRKAEQGVKIFVQLYKEVEVVMGLNSEYTKKTL 442

  Fly   677 -AKHENIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSISTS 740
             ..|.||:|:|||||.....||||||||.|||||:.||:|||||.||||||:.|||.|:||:
Zfish   443 MGLHSNIRVIRHPDHMPSTALLWAHHEKSVVIDQSLAFLGGIDLAYGRWDDYQHRLADVGSV--- 504

  Fly   741 SFSGSTRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRL 805
                  ||:|                             ::.|:..|...:.|:  .|::.|:.:
Zfish   505 ------RRSP-----------------------------QQSPAISPSLTHQSV--ATVEEGEEV 532

  Fly   806 LI-------------------------PSTLVSS-----PGETPAESGIALEGMK-LNTPEMERK 839
            .:                         ||.:.:|     |.|...|:.:.|...: |.||..:..
Zfish   533 KLNVVVEEIHIGEGGAGRAGDAGSMEDPSEICTSFMMTMPKEDQRENSLTLPTERLLRTPSEKSH 597

  Fly   840 NVLDRLKNNAMKGARMGKDFMHRLT--ATETEEKSAEVYTIESEEATDHEVNLNMASGGQEVAIT 902
            :..|     |.:..|..:..::..|  ..|...||..:::.:|.....|..        ..:...
Zfish   598 HSFD-----AAESKRYSRTSLNSRTPLTLECYTKSLSLHSSDSYSLGLHHC--------LPLPYE 649

  Fly   903 TSSTQIL---SEFCGQAKYWFGKDYSNFILKDWMNLNSPFVDIIDRTTTPRMPWHDVGLCVVGTS 964
            |||.:..   :|.||:.::|.||||.|||||||:.||.||.|.|||..||||||||:|:.|.|.:
Zfish   650 TSSLRSYIGSTELCGETRFWHGKDYCNFILKDWVKLNKPFDDFIDRYKTPRMPWHDIGVMVHGKA 714

  Fly   965 ARDVARHFIQRWNAMKLEKLRDN-TRFPYLMPKSYHQVRLNPNIQQNRQQRVTCQLLRSVSAWSC 1028
            |||:|||||||||..||.|.|.. |.:|.|||||. ...:.|....:|..:...|:||||..||.
Zfish   715 ARDIARHFIQRWNFTKLVKKRSGATCYPCLMPKSL-CAPMMPAEYTDRSTQANVQVLRSVCQWST 778

  Fly  1029 GFIEADLVEQSIHDAYIQTITKAQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRA 1093
            |   :.:.|:|||.||:..|..::|::||||||||:.        |...:.|.||:.|.:||:||
Zfish   779 G---SKVHEESIHLAYVSAIQNSKHFIYIENQFFISC--------ADKTIHNSIGDALTERILRA 832

  Fly  1094 HKERKPFRVYVIMPLLPGFEGDVGGSTGIAVRAITHWNYASISRGRTSILTRLQ----EAGIANP 1154
            ::|:|.|||||:||||||||||:....|.|::||.|:||.::.||..||:.||:    :..|
Zfish   833 YREKKRFRVYVVMPLLPGFEGDISSGGGQAIKAIMHFNYRTMCRGEHSIIERLKCVMSDCWI--- 894

  Fly  1155 ENYISFHSLRNHSFLNNTPITELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDE 1219
             .||||..||.|:.|:...:||||||||||:|.||..||.||||||||||:||||||:|.::.|.
Zfish   895 -KYISFCGLRTHADLDGRLVTELIYVHSKLMIVDDCTVIIGSANINDRSMLGKRDSEMAVVVEDT 958

  Fly  1220 EFEDGRMNGKKYPSGVFAGRLRKYLFKEHLGLLESEGSSRSDLDINDPVCEKFWHGTWRRISMQN 1284
            |.:...|:|:.:.:|.||..|||..|:..|||.|      .:.||:|||.::|:...|...:.:|
Zfish   959 ELQSSVMDGESFQAGRFARSLRKECFRLVLGLPE------DNTDISDPVSDRFYKEIWMVTAARN 1017

  Fly  1285 TEIYDEVFKCIPTDFVKTFASLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTP 1349
            ..:||:||:|:|||.|..:..||:|...|.:|...|..|.:....|:|:||..||.||::|.|.|
Zfish  1018 ASVYDKVFRCLPTDAVLNYKILREYTCRPCMATEDPAQACSELKKIRGFLVQFPLHFLSEENLFP 1082

  Fly  1350 PGTSKEGLIPTSVWT 1364
            ...||||::|..:||
Zfish  1083 SFNSKEGMMPIELWT 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	67/200 (34%)
		PH_PLD	419..564	CDD:269956	53/145 (37%)
		PLDc_vPLD1_2_yPLD_like_1	590..734	CDD:197236	92/144 (64%)
		PLDc_vPLD1_2_yPLD_like_2	1032..1220	CDD:197239	97/191 (51%)
si:ch211-168k14.2	XP_017213317.1	PLN02866	72..1088	CDD:215467	464/1174 (40%)
		PX_PLD	80..213	CDD:132805	67/199 (34%)
		PH_PLD	201..330	CDD:269956	53/145 (37%)
		PLDc_vPLD1_2_yPLD_like_1	356..501	CDD:197236	92/144 (64%)
		PLDc_SF	<702..727	CDD:301585	17/24 (71%)
		PLDc_vPLD1_2	779..959	CDD:197302	98/194 (51%)
		PLDc_SF	<920..1008	CDD:301585	47/93 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	236	1.000	Domainoid score	I2276
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H112355
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330134at33208
OrthoFinder	1	1.000	-	-		FOG0001475
OrthoInspector	1	1.000	-	-		otm24539
orthoMCL	1	0.900	-	-		OOG6_100567
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820