DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pld and pld1

DIOPT Version :9

Sequence 1:	NP_001137610.1	Gene:	Pld / 35554	FlyBaseID:	FBgn0286511	Length:	1364	Species:	Drosophila melanogaster
Sequence 2:	NP_592986.1	Gene:	pld1 / 2542065	PomBaseID:	SPAC2F7.16c	Length:	1369	Species:	Schizosaccharomyces pombe

Alignment Length:	1618	Identity:	387/1618 - (23%)
Similarity:	586/1618 - (36%)	Gaps:	654/1618 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 PYAL-TNSDE----EHGSGEEDASEENSNNEEGEGVFRDCTD-EAVVEHHNRCLPE------FQF 151
            ||:| ||.::    |.|:|.:||.:...:.         .|| |..|:|.....||      .:|
pombe    15 PYSLNTNVNDSIYSEKGTGRKDAEDHTPSK---------ITDLEKNVDHSIPSFPENDPKNYSEF 70

  Fly   152 SLVD------------------SEYDETLAFPDSVTILS-----------NVGDKPVLVERKETD 187
            ..::                  ||....||..||..:.:           ||...|  :||.|.|
pombe    71 VNLNPPKRPDLEHTRGSSWHTASENVNDLAANDSTRVQTPEFITQTMEDENVEVPP--LERDERD 133

  Fly   188 DDEEEFDDEENNSV---------------------VLRHEIPFTSIYGPSVKFNSFQRKVFIPGR 231
            ...........||.                     :|:..:|..:::...:..:....|.||..:
pombe   134 AAAAHTSKANRNSARQMWAQLMASVRKFKREDEKPILKENLPAINLFEAGIPASLPIAKHFIRDK 198

  Fly   232 E-----------IHVRIVDTERSVTTHLLNPNLYTIELTHG----PFKWTIKRRYKHFNSLHQQL 281
            .           |.|.::|.|   ..|....:.:||::.:|    ..:|.|.|:.:.|.:||...
pombe   199 SGQPVLPIITDLIKVSVLDVE---PKHNRIHSTFTIQVEYGTGPHAIRWLIYRQLRDFINLHSHF 260

  Fly   282 SFFRTSLNIPFPSRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSN 346
            .||.      |..| ...:|..|....:|:        ||...|::          ...||..||
pombe   261 LFFE------FQHR-FSGRRMKLPKFPKEV--------LPYLVKLR----------GYQKILYSN 300

  Fly   347 ANNAMAMISPNHSSILAGLT--------------PRRIQKKRKKKKKRKLPRFPNRPESLVTVEN 397
            .::  .:|...||  ::.::              ||.....|||.            .:..|::.
pombe   301 PSD--QLIDETHS--ISDISWESHSQDGDRTTGQPRHANNGRKKH------------GNFWTIQG 349

  Fly   398 LSVRIKQLEDYLYNL-----LNISLYRSHHETLNFVEVSNVS-FVPGMG-IKGKEG-VILKRTGS 454
            .::.: .|::.::||     :|: ||       :|:|.|::. ::.|.| ..|||| ..|||..|
pombe   350 NTLGV-YLQEMIHNLQFFPEVNV-LY-------SFLEFSSLGLYLAGAGTFHGKEGFATLKRNYS 405

  Fly   455 TRPGQAGCN----------FFGCFQKNCCVRCNYFCSDVVCGTWRNRWFFVKETCFGYIRPTDGS 509
            .......||          |:....::|.:.|:...|                     ::|.|
pombe   406 PTQYMLCCNTTMMKTRSQPFWIIVSESCIILCDNMLS---------------------MQPAD-- 447

  Fly   510 IRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNR----HIVLKCWTRRKCKE-------WMQYLKN 563
               |.::|..|:::    :...||.....||.:    |...|...|:|..:       |:|...|
pombe   448 ---VFIWDVDFEIT----RKNFRKAHSKDTNEKIRLSHHSFKIKNRQKVMKLSVRSGRWLQQFIN 505

  Fly   564 TANSYARDFTL---PNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAALEEIYIADWWLSPEI 625
            :. ..|:..|.   .:...||||:|.|....|.||...:|..|:..::.|...|.|..||||||:
pombe   506 SV-QVAQGLTAWCEIHRFDSFAPVRTNVAVQWMVDARDHMWNVSRAIKNAKRCIMIHGWWLSPEL 569

  Fly   626 YMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKSTL-AKHENIKVMRHPD 689
            .|:||......||:|:||..||.:||.|::::|:.::..:.|:|:::|..| :.|.||.|:|.|.
pombe   570 QMRRPYSMAHKWRIDRILNEKAHEGVMVYIMIYRNIDATIPIDSFHTKEHLQSLHPNIYVIRSPS 634

  Fly   690 HARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSISTSSFSGSTRRTPSLYF 754
            |.|...|.||||||:||:|....|:||||||:||:|...|.|.|
pombe   635 HFRQNALFWAHHEKLVVVDDAITFIGGIDLCFGRYDTPQHILYD--------------------- 678

  Fly   755 TKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRLLIPSTLVSSPGETP 819
                                             |:|
pombe   679 ---------------------------------DKP----------------------------- 681

  Fly   820 AESGIALEGMKLNTPEMERKNVLDRLKNNAMKGARMGKDFMHRLTATETEEKSAEVYTIESEEAT 884
                                 |.|:
pombe   682 ---------------------VADK---------------------------------------- 685

  Fly   885 DHEVNLNMASGGQEVAITTSSTQILSEFCGQAKYWFGKDYSNFILKDWMNLNSPFVDIIDRTTTP 949
                                     :..|.|.  |.||||||..:.|:.:|..|:.|:.||...|
pombe   686 -------------------------TGLCEQT--WRGKDYSNARVHDFFDLTEPYKDMYDRLAVP 723

  Fly   950 RMPWHDVGLCVVGTSARDVARHFIQRWNAMKLEKLRDNTRFPYLMPKSYHQVRLNPNIQQNR--- 1011
            ||.||||.:|::|..|||.||||:||||.: ::..:...:.|.|:|.        |:...::
pombe   724 RMGWHDVSMCIIGQPARDAARHFVQRWNYL-IQCKKPARKTPLLIPP--------PDFTTDQLTD 779

  Fly  1012 -QQRVTC--QLLRSVSAWSCGFIEADLVEQSIHDAYIQTITKAQHYVYIENQFFITMQLGMGVPG 1073
             |...||  |:|||...||.|.:  |.|||||.:||:..|.|::|::|||||||:|.....|
pombe   780 SQLTGTCEVQVLRSAGLWSLGLV--DTVEQSIQNAYVTCIEKSEHFIYIENQFFVTSTTCEG--- 839

  Fly  1074 AYNNVRNQIGETLFKRIVRAHKERKPFRVYVIMPLLPGFEGDVGGSTGIAVRAITHWNYASISRG 1138
              ..:.|::|:.|.:||:||||..:.:|..:::||||||||.:....|.::|.|....|.||..|
pombe   840 --TTIENRVGDALVERIIRAHKNNEKWRGVIMIPLLPGFEGQIDLQEGGSLRLIVECQYRSICHG 902

  Fly  1139 RTSILTRLQEAGIANPENYISFHSLRNHSFL--NNTPITELIYVHSKLLIADDRVVICGSANIND 1201
            ..||..||...|| :...|:.|:.||..:.|  |:..:||:||||:|:|||||||.:.||||||:
pombe   903 EHSIFGRLNAKGI-DGSKYLRFYGLRGWAHLGENHELVTEMIYVHAKILIADDRVAVIGSANINE 966

  Fly  1202 RSMIGKRDSEIAAILMDEEFEDGRMNGKKYPSGVFAGRLRKYLFKEHLGL----LE--------- 1253
            ||::|.|||||||::.|....|.:|:||.|..|.||..|||.|.:|||||    ||
pombe   967 RSLLGNRDSEIAAVIRDTLTIDSKMDGKPYKVGKFAHTLRKRLMREHLGLETDVLEQREYNMDGL 1031

  Fly  1254 --------------SEGSS---------------RSD---------------------------- 1261
                          .||::               ||.
pombe  1032 DRDTEWKRVEVWTPDEGNAINGSAYTAEELKMKYRSQSQFTTTPDILRKAEKSMKKLDQRVSLIP 1096

  Fly  1262 ----------------------------------------------------------------- 1261

pombe  1097 SSIEFNIKTQKDKVEFEKNYEKSKKGPDVIANALVGGIPLSLKTKEDSLYELSKFSQCGEDQRPM 1161

  Fly  1262 -----------------------------LDIN----------------DPVCEKFWHGTWRRIS 1281
                                         |::|                ||||::|:...|.:::
pombe  1162 VLKDPDHLVPEPSRPHCGNGLVFYDDIPLLEVNPISGETIPKFDASSFEDPVCDEFFEDIWSKVA 1226

  Fly  1282 MQNTEIYDEVFKCIPTDFVKTFASL---RKY------------QEE--------------PPLAK 1317
            ..||.||..:|:|:|.|.:.|:.|.   :||            |||              |...|
pombe  1227 SNNTTIYRHIFRCVPDDEMLTWESYNEWKKYGKRFKEEQARWRQEELSNLHETHEKSENDPKNPK 1291

  Fly  1318 TAPDLAAN--------------RAND----------------IQGYLVDLPLEFLNKE 1345
            .....:.|              |.|:                |:|.||:|||::::.|
pombe  1292 AGSQGSGNTSASEDSKTEKPKTRTNNGLQVPDKRVVYDLLRGIRGQLVELPLKWMSTE 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	45/234 (19%)
		PH_PLD	419..564	CDD:269956	34/168 (20%)
		PLDc_vPLD1_2_yPLD_like_1	590..734	CDD:197236	62/144 (43%)
		PLDc_vPLD1_2_yPLD_like_2	1032..1220	CDD:197239	88/189 (47%)
pld1	NP_592986.1	PX	215..377	CDD:214610	42/214 (20%)
		PH_PLD	369..510	CDD:269956	38/179 (21%)
		PLDc_vPLD1_2_yPLD_like_1	534..679	CDD:197236	63/198 (32%)
		PLDc_vPLD1_2_yPLD_like_2	805..984	CDD:197239	86/184 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I1852
eggNOG	1	0.900	-	-		E1_COG1502
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	483	1.000	Inparanoid score	I263
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001475
OrthoInspector	1	1.000	-	-		oto101259
orthoMCL	1	0.900	-	-		OOG6_100567
Panther	1	1.100	-	-	O	PTHR18896
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2299
SonicParanoid	1	1.000	-	-		X1041
TreeFam	1	0.960	-	-
	11	10.850