Protein Alignment Pld and Pld2

DIOPT Version :10

• Sequence 1: NP_001137610.1
• Gene: Pld / 35554
• FlyBaseID: FBgn0286511
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: XP_038941178.1
• Gene: Pld2 / 25097
• RGDID: 3350
• Length: 972
• Species: Rattus norvegicus
• Alignment Length: 1243
• Identity: 448/1243 - (36%)
• Similarity: 598/1243 - (48%)
• Gaps: 337/1243 - (27%)

  Fly   165 PDSVTILSNVGDKPVLVERKETDDDEEEFDDEENNSVVLRHEIPFTSIYGPSVKFNSFQRKVFIP 229
            ||.|..|            ||.:|..:...             ||.:||  .::.......||.|
  Rat    24 PDEVDTL------------KEGEDPADRMH-------------PFLAIY--DLQPLRAHPLVFAP 61

  Fly   230 GREIHVRIVDTERSVTTHLLNP-NLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRTSLNIPFP 293
            |..:..::|.|||..:...:.. .||::.||||.|.||.|::::||..||
  Rat    62 GVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELH--------------- 111

  Fly   294 SRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAMAMISPNH 358
                                    :||..| ||..:..||                  |..:..|
  Rat   112 ------------------------RDLQRH-KVLMSLLPL------------------ARFAAAH 133

  Fly   359 SSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNLLNISLYRSHHE 423
            |       |.|      :.....:|..| |..|..:..:.:.:.|.||:||..||.:|.||::|.
  Rat   134 S-------PAR------EAANENIPSLP-RGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHA 184

  Fly   424 TLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTR-PGQAGCNFFGCFQKNCCVRCNYFCSDVVCGT 487
            ...|:|||.:||:|.:|.||.||||.||:|..| ||           ..||.|      |.||..
  Rat   185 MTEFLEVSQLSFIPDLGSKGLEGVIRKRSGGHRVPG-----------FTCCGR------DQVCYR 232

  Fly   488 WRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHIVLKCWTRR 552
            |..||..||::...|:||..|:|..|.|||.||:|..|...|..|.|:::.|::|.::|||.:.|
  Rat   233 WSKRWLVVKDSFLLYMRPETGAISFVQLFDPGFEVQVGKRSTEARYGVRIDTSHRSLILKCSSYR 297

  Fly   553 KCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAALEEIYIA 617
            :.:.|.|.:...|....|||...:.|.|:||.|..|.|.|:|:||.|.:||||.:..|.|||:|.
  Rat   298 QARWWGQEITELAQGPGRDFLQLHQHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAREEIFIT 362

  Fly   618 DWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKSTL-AKHEN 681
            |||||||||:|||| ..|.||||.:|.||||:||||.:||:||||:||||||.|||.|| ..|.|
  Rat   363 DWWLSPEIYLKRPA-HSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRTLMLLHPN 426

  Fly   682 IKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSISTSSFSGST 746
            ||||||||.    :.|||||||::|:||..||:||:||.||||||..:||||||
  Rat   427 IKVMRHPDL----VTLWAHHEKLLVVDQAVAFLGGLDLAYGRWDDVQYRLTDLG----------- 476

  Fly   747 RRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRLLIPSTL 811
                                                      :|:.|.:.:|..||
  Rat   477 ------------------------------------------DPSESADSQTPTPG--------- 490

  Fly   812 VSSPGETPAESGIALEGMKLNTPEMERKNVLDRLKNNAMKGARMGKDFMHRLTATETEEKSAEVY 876
             |.|..||                                      |..|
  Rat   491 -SDPAATP--------------------------------------DLSH--------------- 501

  Fly   877 TIESEEATDHEVNLNMASGGQEVAITTSSTQILSEFCGQAKYWFGKDYSNFILKDWMNLNSPF-- 939
                                             :.|     :|.||||||.|.|||:.|:.||
  Rat   502 ---------------------------------NHF-----FWLGKDYSNLITKDWVQLDRPFEE 528

  Fly   940 -------------------------------------VDIIDRTTTPRMPWHDVGLCVVGTSARD 967
                                                 .|.|||.|||||||.|||:.|.|.:|||
  Rat   529 EVRTGTQPEQEPGGLLLPGSFPVDSSVSFLPEPRTTTPDFIDRETTPRMPWRDVGVVVHGVAARD 593

  Fly   968 VARHFIQRWNAMKLEKLRDN-TRFPYLMPKSYHQVRLNPNIQQNRQQRVTCQLLRSVSAWSCGFI 1031
            :|||||||||..|..|.|.. .::|||:|||.......|.|... .|..|.|:||||..||.|.:
  Rat   594 LARHFIQRWNFTKTIKARYKIPQYPYLLPKSASTANHLPFIIPG-AQCATVQVLRSVDRWSAGTL 657

  Fly  1032 EADLVEQSIHDAYIQTITKAQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKE 1096
            |:     ||.:||:.||.::||::||||||||:...|       ..|.|::|:.:..||::||::
  Rat   658 ES-----SILNAYLHTIRESQHFLYIENQFFISCSDG-------RTVLNKVGDEIVDRILKAHEQ 710

  Fly  1097 RKPFRVYVIMPLLPGFEGDVGGSTGIAVRAITHWNYASISRGRTSILTRLQEAGIANPENYISFH 1161
            .:.|||||::|||||||||:....|.:::||.|:.|.::.||..|||.||:.|......:|:|..
  Rat   711 GQCFRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYMSIC 775

  Fly  1162 SLRNHSFLNNTPITELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFEDGRM 1226
            .||.|..|...||:||||:||||||||||.||.|||||||||::||||||:|.::.|.|.|...|
  Rat   776 GLRTHGELGGHPISELIYIHSKLLIADDRTVIIGSANINDRSLLGKRDSELAILIEDTEMEPSLM 840

  Fly  1227 NGKKYPSGVFAGRLRKYLFKEHLGLLESEGSSRSDLDINDPVCEKFWHGTWRRISMQNTEIYDEV 1291
            :|.:|.:|.||..|||:.|...||     .::..|||:.||||:.|:. .|:..:..|..||:::
  Rat   841 DGVEYQAGRFALSLRKHCFSVILG-----ANTWPDLDLRDPVCDDFFQ-LWQETAENNATIYEQI 899

  Fly  1292 FKCIPTDFVKTFASLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEG 1356
            |:|:|::..::..:||:|.....||..:|.||.:....|:|:||..||:||..|.|.||..||||
  Rat   900 FRCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIRGHLVHFPLKFLEDESLLPPLGSKEG 964

  Fly  1357 LIPTSVWT 1364
            :||..|||
  Rat   965 MIPLEVWT 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	48/201 (24%)
		PLN02866	388..1349	CDD:215467	390/1002 (39%)
Pld2	XP_038941178.1	PLN02866	67..957	CDD:215467	422/1156 (37%)