DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pld and Pld1

DIOPT Version :9

Sequence 1:	NP_001137610.1	Gene:	Pld / 35554	FlyBaseID:	FBgn0286511	Length:	1364	Species:	Drosophila melanogaster
Sequence 2:	XP_006232267.1	Gene:	Pld1 / 25096	RGDID:	3349	Length:	1074	Species:	Rattus norvegicus

Alignment Length:	1245	Identity:	447/1245 - (35%)
Similarity:	631/1245 - (50%)	Gaps:	232/1245 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 TILSNVGDKPVLVERKET-----DDDEEEFDDEENNSVVLRHEIPFTSIYGPSVKFNSFQRKVFI 228
            |:.....|...|:|..:|     :.:|.|:|....:.......|||:|||. :..|.....::::
  Rat    13 TLQKIAADMSNLIENLDTRELHFEGEEVEYDASPGDPTAQEACIPFSSIYN-TQGFKEPNIQIYL 76

  Fly   229 PGREIHVRIVDTER-SVTTHLLNPNLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRTSLNIPF 292
            .|..:..::::.|| :.|:.:.:.||||||||||.|.|.:||::|||...|::|..::..:.||.
  Rat    77 SGCPVKAQVLEVERFTSTSRMPSVNLYTIELTHGEFTWQVKRKFKHFQEFHRELLKYKAFIRIPI 141

  Fly   293 PSRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAMAMISPN 357
            |::.|..:|..:|...|||
  Rat   142 PTKRHTFRRQNVKEEPREM---------------------------------------------- 160

  Fly   358 HSSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNLLNISLYRSHH 422
                                     |..|...|:.:..|....|.|||||||..:|.:.:||::|
  Rat   161 -------------------------PSLPRSSENAIQEEQFFGRRKQLEDYLTKILKMPMYRNYH 200

  Fly   423 ETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTR-PGQAGCNFFGCFQKNCCVRCNYFCSDVVCG 486
            .|..|::||.:||:..:|.||.||:|:||:|..| ||           .|||....      .|.
  Rat   201 ATTEFLDVSQLSFIHDLGPKGLEGMIMKRSGGHRIPG-----------VNCCGHGR------ACY 248

  Fly   487 TWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHIVLKCWTR 551
            .|..||..||::...|::|..|:|..|:|.|:.|.:..|..:|..:.||::...:|.::|||.:.
  Rat   249 RWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFRIKVGKKETETKYGLRIDNLSRTLILKCNSY 313

  Fly   552 RKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAALEEIYI 616
            |..:.|...::.....:..||...:...|:|.:..|..|.|||:...|...:|:.:|.|.|||:|
  Rat   314 RHARWWGGAIEEFIQKHGTDFLKDHRFGSYAAVHENILAKWYVNAKGYFEDIANAMEGATEEIFI 378

  Fly   617 ADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKSTLAK-HE 680
            .||||||||::|||.::|:.||||.||.|||:||||:|::||||||:||||||.|:|.||.: |.
  Rat   379 TDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHP 443

  Fly   681 NIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSISTSSFSGS 745
            ||||||||||....:.|||||||:|:|||:.||:|||||.||||||:.|||||:||:
  Rat   444 NIKVMRHPDHVSSSVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSV-------- 500

  Fly   746 TRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRLLIPST 810
                                                               |.:..|..|
  Rat   501 ---------------------------------------------------KRVTSGQSL----- 509

  Fly   811 LVSSPGETPAESGIALEGMKLNTPEMERKN--VLDRLKNNAMKGARMGKD------FMHRLTATE 867
                 |...|.|..::|.:.|.......||  ||..:.:..||...:||.      .::|.....
  Rat   510 -----GSLTAASVESMESLSLKDKHQSHKNEPVLKSVNDTDMKLKGIGKSRKFSKFSLYRQLHRR 569

  Fly   868 TEEKSAEVYTIESEEA-----TDHE---------VNLNMASGGQEVAITTSSTQI---------L 909
            ....|..:.:::|..:     ..|:         :.|...|...|..:|..|...         :
  Rat   570 NLHNSDSISSVDSASSYFNHYRSHQNLIHGLKPHLKLFRPSSESEQGLTRHSADTGSIRSVQTGV 634

  Fly   910 SEFCGQAKYWFGKDYSNFILKDWMNLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQ 974
            .|..|:.::|.||||.||:.|||:.|:.||.|.|||.:||||||||:|..|.|.:||||||||||
  Rat   635 GELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIGSVVHGKAARDVARHFIQ 699

  Fly   975 RWNAMKLEKLR-DNTRFPYLMPKSY---HQVRLNPNIQQNRQQRVTCQLLRSVSAWSCGFIEADL 1035
            |||..|:.|.: .:..:|:|:|||.   |::|    .|.........|||||.:.||.|....
  Rat   700 RWNFTKIMKPKYRSLSYPFLLPKSQATAHELR----YQVPGAVHAKAQLLRSAADWSAGIKHH-- 758

  Fly  1036 VEQSIHDAYIQTITKAQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPF 1100
             |:|||.||...|..::||:||||||||:.       .....|.|::|..:.:||::||:|.:.:
  Rat   759 -EESIHAAYTHVIENSKHYIYIENQFFISC-------ADDKVVFNKVGNAIAQRILKAHREGQRY 815

  Fly  1101 RVYVIMPLLPGFEGDVGGSTGIAVRAITHWNYASISRGRTSILTRLQEAGIANPE------NYIS 1159
            |||:::|||||||||:....|.|::||.|:||.::.||.:|||.:|:      ||      ||||
  Rat   816 RVYIVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGESSILEQLK------PELGNKWINYIS 874

  Fly  1160 FHSLRNHSFLNNTPITELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFEDG 1224
            |..||.|:.|....:|||||||||||||||..||.||||||||||:||||||:|.|:.|.|....
  Rat   875 FCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPS 939

  Fly  1225 RMNGKKYPSGVFAGRLRKYLFKEHLGLLESEGSSRSDLDINDPVCEKFWHGTWRRISMQNTEIYD 1289
            .|:||:|.:|.||..||...|:..||.|.....     ||.|||.:||:...|...:.:|..|||
  Rat   940 VMDGKEYQAGRFAQGLRLECFRLVLGYLSDPSE-----DIQDPVSDKFFKEIWVSTAARNATIYD 999

  Fly  1290 EVFKCIPTDFVKTFASLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTPPGTSK 1354
            :||:|:|.|.|.....||.:..:|.|||.....|......|:|:||..|..||::|.|.|...:|
  Rat  1000 KVFRCLPNDEVHNLIQLRDFINKPILAKEDRLRAEEELRKIRGFLVQFPFYFLSEENLLPSVGTK 1064

  Fly  1355 EGLIPTSVWT 1364
            |.::|..|||
  Rat  1065 EAIVPMEVWT 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	50/201 (25%)
		PH_PLD	419..564	CDD:269956	47/145 (32%)
		PLDc_vPLD1_2_yPLD_like_1	590..734	CDD:197236	93/144 (65%)
		PLDc_vPLD1_2_yPLD_like_2	1032..1220	CDD:197239	97/193 (50%)
Pld1	XP_006232267.1	PX_PLD1	78..209	CDD:132829	50/201 (25%)
		PLN02866	82..1059	CDD:215467	424/1158 (37%)
		PH_PLD	197..326	CDD:269956	47/145 (32%)
		PLDc_vPLD1_1	352..502	CDD:197300	96/208 (46%)
		PLDc_vPLD1_2	754..935	CDD:197302	98/196 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346217
Domainoid	1	1.000	176	1.000	Domainoid score	I3517
eggNOG	1	0.900	-	-		E1_COG1502
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	716	1.000	Inparanoid score	I610
OMA	1	1.010	-	-		QHG58673
OrthoDB	1	1.010	-	-		D330134at33208
OrthoFinder	1	1.000	-	-		FOG0001475
OrthoInspector	1	1.000	-	-		otm45467
orthoMCL	1	0.900	-	-		OOG6_100567
Panther	1	1.100	-	-	LDO	PTHR18896
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1041
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770