DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pld and pld-1

DIOPT Version :9

Sequence 1:	NP_001137610.1	Gene:	Pld / 35554	FlyBaseID:	FBgn0286511	Length:	1364	Species:	Drosophila melanogaster
Sequence 2:	NP_494939.1	Gene:	pld-1 / 173876	WormBaseID:	WBGene00004040	Length:	1427	Species:	Caenorhabditis elegans

Alignment Length:	1496	Identity:	519/1496 - (34%)
Similarity:	739/1496 - (49%)	Gaps:	302/1496 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LTNSDEEH------GSGEEDASEENSNNEEGEGVFRD-----------CTD---EAVV---EHHN 143
            :.:.|||.      .||..:..:...||.....|..|           .:|   :||:   ||..
Worm     1 MESEDEESRRPQTTSSGHLEPKDTTENNSVDSSVMHDRGIPGLLPATKASDKQKKAVIRFREHEG 65

  Fly   144 RCLPEFQFSLVDSEYDETLAFPDSVTILSNVGDKPVLVERKETDD--DEEEFDDEENNSVVLRHE 206
            |         .||.........||.|:..:....|..::..::||  |::|....:..:..|:..
Worm    66 R---------ADSPPSNLNVRRDSKTVHIDEVSSPQSLDYGDSDDSSDDDEIQYCDCVAAALQQS 121

  Fly   207 ----------IPFTSIYGPSVKFNSFQRKVFIPGREIHVRIVDTERSVT--THLLNPNLYTIELT 259
                      ||:.|||  ..:..:.:|..:|||..::.:||..||:..  .|.:|..||||||.
Worm   122 LPGTPGRKGIIPYMSIY--DTQQQARRRGYWIPGVPVNAKIVKVERNTDRGIHFINTLLYTIELE 184

  Fly   260 HGPFKWTIKRRYKHFNSLHQQLSFFRT----------------------SLNI--------PFPS 294
            ||.|:|::.|.||.|..|:.:|...|.                      .::|        |:.:
Worm   185 HGQFRWSVIRNYKDFTLLNNRLMAHRAREQFMAPIKRTQERFDNYLEHMGIDIISDHKPECPYSN 249

  Fly   295 RSHKEKR-TTLKATAREM--ADESTLKDLPSHTKVKQTSTPL---RAEGRSSKIAGSNANNAMAM 353
            :|.|.|| ..|:...|:.  .:||           |.||.||   .:.|..........:...|:
Worm   250 QSSKRKRHPKLQVLKRDSDGIEES-----------KNTSAPLASVESPGEVEDAFKKEVHMQQAV 303

  Fly   354 IS------PNHSSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNL 412
            .|      .|.::...| ||:|.:::::||.:..|||||..|:|:||  ||..|.:.||::|..:
Worm   304 QSGILDETVNEANTSEG-TPKRQRRQQRKKDRHTLPRFPMMPDSMVT--NLEHRKELLENWLQMV 365

  Fly   413 LNISLYRSHHETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTRPGQAGCNFFGCFQKNCCVRCN 477
            |:|.:.|:||||..|:|||..|||..:|.|..||.:.||.|.:|.      |.|  .|.||||
Worm   366 LHIPINRNHHETAEFLEVSRYSFVNELGGKHTEGFVKKRPGGSRV------FLG--WKQCCVR-- 420

  Fly   478 YFCSDVVCGTWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQT-GMRKGLQVLTNN 541
            |..      .|..||..|:::...|:......||.|:|.|:.|.|:.|..:| |:..|| ::||:
Worm   421 YLL------PWSKRWLMVRDSFVAYMDHRTEQIRMVLLMDRDFKVAAGGKETEGIPTGL-IITNS 478

  Fly   542 RH-IVLKCWTRRKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVAD 605
            :| :.|||...:....|...::.........:..|:...|..|:|.|.||.|:||...||...||
Worm   479 QHELHLKCRRLQDTATWKYIIEQAMGGIGNTWLQPHRFSSSFPVRENCHAKWFVDAKTYMEYAAD 543

  Fly   606 GLEAALEEIYIADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSY 670
            .:|.|.|||||.|||||||||||||||:|:|||||:||.|||||||::|:|||||:|||||:||.
Worm   544 MMELAREEIYITDWWLSPEIYMKRPALEGNYWRLDEILKRKAEQGVKIFILLYKEMEMALGLNSI 608

  Fly   671 YSKSTL-AKHENIKVMRHPDH-ARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTD 733
            |||.|| ..|||||||||||| ...|...||||||:::|||..:|:||:|||:||||||.|.|||
Worm   609 YSKRTLQGLHENIKVMRHPDHYPSTGTFFWAHHEKLLIIDQLISFVGGVDLCFGRWDDHRHLLTD 673

  Fly   734 LGS--------ISTSSFSG---------------------------------------------- 744
            |||        ::|:..||
Worm   674 LGSVQYSGAHQVATNMASGLRSLMTAPLTLSPLGLEEHEKVTPRNENGGKNGSVKRVAVEEINEV 738

  Fly   745 -----STRRTPSLYFTKDD-----------------TDSAFGS--RKSSRNAHYDTSAKERPPSP 785
                 .|.||.....|.::                 ||...|.  .::......|.:.:...|:.
Worm   739 DEPKEVTGRTQETELTDNEDISEDSDVKKIMEETIFTDKETGGVVVRTLNRFPVDEAIRHSSPAD 803

  Fly   786 PP---DEPNTSIELKTLKPGDRLLIPSTLVSSPGETPAESGIALEGMK--------LNTPEMERK 839
            |.   .|..|::...|...|.   :.|...::...|.......||..|        :.:.|.:||
Worm   804 PQKNWKETKTTVVESTSTSGG---VTSKTTTTTTTTRVVKDNTLEKEKNKKELRRAVTSLERQRK 865

  Fly   840 NVLDRLKNNA-------MKGARMGKDF-------------------MHRLTATETEEKSAE---- 874
            :|...:.:.|       .|.|:.|.||                   .||........|:.:
Worm   866 HVPREILDKAGPAPSMIEKAAKSGMDFASAAEKYKEYVASGAVQKEKHRAQTPPNRRKAKKDSRI 930

  Fly   875 -------------------VYTIESEEAT-DHEVN------LNMASGGQEVAITTSSTQILSEFC 913
                               ...:||:||| .:|::      ::....|.:            |..
Worm   931 TRAVGAVGNWKSNRAKRKWKQMLESDEATMGYELDWLRLREMDEKGDGDD------------EID 983

  Fly   914 GQAKYWFGKDYSNFILKDWMNLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNA 978
            |.||.|:||||.|:|.||::.::.||.|.|||.:||||||||:.....|..|||:||||||||||
Worm   984 GGAKLWYGKDYVNYIAKDFVEVDMPFHDFIDRGSTPRMPWHDIHSVTFGAPARDLARHFIQRWNA 1048

  Fly   979 MKLEKLRDNTRFPYLMPKSYHQVRLNPNI--QQNRQQRVTCQLLRSVSAWSCGFIEADLVEQSIH 1041
            .|.|||:|:..:|||:||||..||: |.:  ..|..:.|..|:|||:|.|| |.|  :..|.||.
Worm  1049 TKTEKLKDDKNYPYLLPKSYENVRV-PRVFKTANASEMVNVQVLRSLSNWS-GLI--NQTEDSIQ 1109

  Fly  1042 DAYIQTITKAQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIM 1106
            .||:..|..::||:|||||||::|.       ..|:|.|::.:.::.|||||:||:..:|||:::
Worm  1110 MAYLSLIANSKHYIYIENQFFVSMI-------ESNDVTNEVCKVIYNRIVRAYKEKDNYRVYIMI 1167

  Fly  1107 PLLPGFEGDVGGSTGIAVRAITHWNYASISRGRTSILTRLQEAGIANPENYISFHSLRNHSFLNN 1171
            |||||||||||...|.:::|:.||.|.|:|:|..|::.|| :|.:.:|..||...|||.:..|..
Worm  1168 PLLPGFEGDVGAPGGSSLQAVLHWTYQSLSQGPNSLIQRL-KAVMPDPFKYIHVGSLRTYDQLGQ 1231

  Fly  1172 TPITELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMNGKKYPSGVF 1236
            ..::||:|:|.||||.||..||.|||||||||..|.||||:..:..|...|...|:||.:.:|.|
Worm  1232 KLVSELVYIHCKLLIVDDEHVIIGSANINDRSQCGNRDSEVCCVYTDVVKERSVMDGKPFEAGRF 1296

  Fly  1237 AGRLRKYLFKEHLGLL-ESEGSSRSD--LDINDPVCEKFWHGTWRRISMQNTEIYDEVFKCIPTD 1298
            |..||....:|||||| :|...::..  :..:|||.:.|:...|:..:..|.:||:|||:..|||
Worm  1297 AKSLRMQCMREHLGLLPDSRRKAKFPYAVSCDDPVADSFFVDVWQSTAKSNGQIYEEVFRSYPTD 1361

  Fly  1299 FVKTFASLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEGLIPTSVW 1363
            ||:||...:|:..:.|:::.:|..|..|..|::|.|||.||.||.|.||||..||||||:|::|:
Worm  1362 FVETFEEFQKWTSQIPMSEYSPQQAEERVRDLKGVLVDFPLNFLCKAVLTPGITSKEGLVPSAVF 1426

  Fly  1364 T 1364
            |
Worm  1427 T 1427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	73/244 (30%)
		PH_PLD	419..564	CDD:269956	52/146 (36%)
		PLDc_vPLD1_2_yPLD_like_1	590..734	CDD:197236	100/145 (69%)
		PLDc_vPLD1_2_yPLD_like_2	1032..1220	CDD:197239	86/187 (46%)
pld-1	NP_494939.1	PX_domain	153..384	CDD:295365	73/244 (30%)
		PH_PLD	372..502	CDD:269956	52/146 (36%)
		PLDc_vPLD1_2_yPLD_like_1	528..674	CDD:197236	100/145 (69%)
		PLN02866	<988..1426	CDD:215467	209/449 (47%)
		PLDc_vPLD1_2_yPLD_like_2	1101..1278	CDD:197239	86/186 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166449
Domainoid	1	1.000	277	1.000	Domainoid score	I918
eggNOG	1	0.900	-	-		E1_COG1502
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	791	1.000	Inparanoid score	I258
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58673
OrthoDB	1	1.010	-	-		D330134at33208
OrthoFinder	1	1.000	-	-		FOG0001475
OrthoInspector	1	1.000	-	-		oto20320
orthoMCL	1	0.900	-	-		OOG6_100567
Panther	1	1.100	-	-	LDO	PTHR18896
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2299
SonicParanoid	1	1.000	-	-		X1041
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800