Protein Alignment Pld and pld2

DIOPT Version :10

• Sequence 1: NP_001137610.1
• Gene: Pld / 35554
• FlyBaseID: FBgn0286511
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: XP_031753569.1
• Gene: pld2 / 100216200
• XenbaseID: XB-GENE-5998608
• Length: 939
• Species: Xenopus tropicalis
• Alignment Length: 1213
• Identity: 434/1213 - (35%)
• Similarity: 586/1213 - (48%)
• Gaps: 299/1213 - (24%)

  Fly   165 PDSVTILSNVGDKPVLVERKETDDDEEEFDDEENNSVVLRHEIPFTSIYGPSVKFNSFQRKVFIP 229
            |||:       |...||    .|.||.:|..:|......|.  ||.:||  .:|....:|.||:.
 Frog    13 PDSL-------DPGALV----NDIDEVDFSGDEEEDGFPRS--PFLAIY--DMKPLKHERSVFMK 62

  Fly   230 GREIHVRIVDTERSVT-THLLNPNLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRTSLN-IPF 292
            |..:..|:.||||... |.:.:..||||.||||||.||||:::|||..||:.|...:..:: :||
 Frog    63 GVPVTARVSDTERYTRGTKVRHSTLYTIILTHGPFTWTIKKKFKHFQELHRDLLRHKLFISFLPF 127

  Fly   293 P--SRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAMAMIS 355
            .  ||.| ..|:.::.|:.||      ..||            .|.|.:|
 Frog   128 NPLSRFH-VTRSRVETTSSEM------PSLP------------HASGEAS--------------- 158

  Fly   356 PNHSSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNLLNISLYRS 420
                           |:...||                         ..|.:||..||..|.||:
 Frog   159 ---------------QRMASKK-------------------------AYLNNYLNVLLEKSFYRN 183

  Fly   421 HHETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTRPGQAGCNFFGCFQKNCCVRCNYFCSDVVC 485
            :|....|::||.:||:..:|.||.||.|.||:|..|  ..|.|.||..|              :|
 Frog   184 YHAMREFLDVSQLSFIADLGPKGLEGFIQKRSGGHR--IQGLNCFGHHQ--------------IC 232

  Fly   486 GTWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHIVLKCWT 550
            ..|..||..||::...|::|..|.|..|:|||.||.:..|...|..:.|:::....|.:.|||..
 Frog   233 YRWSKRWLVVKDSFLLYLKPDTGEISFVLLFDPGFSIDIGKRTTETKYGVKIQNFTRALTLKCNG 297

  Fly   551 RRKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAALEEIY 615
            .|:...|.|.::..|..:.:||...:....|||:|..|...|:|:|:.|.:||||.|..|.|||:
 Frog   298 YRQASWWGQQIRRLAEDHGKDFLSLHRFDCFAPVREKTQVKWFVNGSTYFAAVADALMQAQEEIF 362

  Fly   616 IADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKSTL-AKH 679
            |.|||||||:::||||...| ||||.||.||||.||||.|||:|||:|||||||.|||..| ..|
 Frog   363 ITDWWLSPEVHLKRPAHTDD-WRLDIILKRKAEAGVRVCVLLFKEVQMALGINSDYSKRVLMLLH 426

  Fly   680 ENIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSISTSSFSG 744
            .||||||||||....:.|||||||:|.|||:..|:||:||.|||||||.:||||:|.:.
 Frog   427 PNIKVMRHPDHVSSVVFLWAHHEKMVAIDQSVVFLGGLDLAYGRWDDHEYRLTDVGPME------ 485

  Fly   745 STRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRLLIPS 809
                                .::.||:...|.:..|...||
 Frog   486 --------------------QQQQSRSMEGDITMNEVEQSP------------------------ 506

  Fly   810 TLVSSPGETPAESGIALEGMKLNTPEMERKNVLDRLKNNAMKGARMGKDFMHRLTATETEEKSAE 874
                                          ||
 Frog   507 ------------------------------NV--------------------------------- 508

  Fly   875 VYTIESEEATDHEVNLNMASGGQEVAITTSSTQILSEFCGQAKYWFGKDYSNFILKDWMNLNSPF 939
                                                     .:||.||||||.|.|||:.|:.||
 Frog   509 -----------------------------------------TQYWLGKDYSNSIYKDWVQLDKPF 532

  Fly   940 VDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNAMKLEKLRDNTRFPYLMPKSYHQVRLN 1004
            .|.|||...|||||.|||..|.|.:||||:||||||||..|..|.:..| :|||:|||....
 Frog   533 EDFIDRMKNPRMPWRDVGAVVHGKAARDVSRHFIQRWNYTKTMKYKAAT-YPYLLPKSLSTA--- 593

  Fly  1005 PNIQQNRQ-------QRVTCQLLRSVSAWSCGFIEADLVEQSIHDAYIQTITKAQHYVYIENQFF 1062
                 :||       .....|:||||..||.|     ..|.||.:||:..|..:|||||:|||||
 Frog   594 -----DRQHYTVPGCHTAAVQVLRSVDWWSAG-----CTEYSILNAYLDCIENSQHYVYLENQFF 648

  Fly  1063 ITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIMPLLPGFEGDVGGSTGIAVRAI 1127
            ||...|       ..:.|.||:.:.|||.:||..:..|||::::||||||:|::....|.:::||
 Frog   649 ITCADG-------RTIFNNIGDAIVKRIQQAHSAKANFRVFIVIPLLPGFQGNIEVGGGYSIQAI 706

  Fly  1128 THWNYASISRGRTSILTRLQEAGIANPENYISFHSLRNHSFL-NNTPITELIYVHSKLLIADDRV 1191
            .|:.|::|.||..||::||:|....:...|:|...||.|..: :.:.:|||:|:|||:||.|||.
 Frog   707 LHYTYSTICRGDNSIISRLKETMGEDWTKYLSVCGLRTHGDMPDGSLVTELVYIHSKMLIVDDRR 771

  Fly  1192 VICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMNGKKYPSGVFAGRLRKYLFKEHLGLLESEG 1256
            ||.||||||||||:|.||||:|.::.|.||....|:|:.|.:|.||..||...|...||...|
 Frog   772 VIIGSANINDRSMLGSRDSELAVLVEDMEFVSSVMDGEPYQAGKFALSLRMDCFNTILGARAS-- 834

  Fly  1257 SSRSDLDINDPVCEKFWHGTWRRISMQNTEIYDEVFKCIPTDFVKTFASLRKYQEEPPLAKTAPD 1321
               ..:|::|||.:.|::..|::.:..||.:||::|:|:|.|.|.:..:|::|.....||...|.
 Frog   835 ---PHIDVSDPVTDHFFNEVWKQTAFNNTYVYDQMFRCLPADAVTSNRTLQEYTAVKNLAALNPG 896

  Fly  1322 LAANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEGLIPTSVWT 1364
            ||..:...|:|:||:.||:||:.|.|.||.:||||||.:.|||
 Frog   897 LAREQLTGIRGHLVECPLQFLSGENLLPPLSSKEGLISSQVWT 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	54/204 (26%)
		PLN02866	388..1349	CDD:215467	359/969 (37%)
pld2	XP_031753569.1	PLN02866	88..938	CDD:215467	403/1120 (36%)