DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bin3 and mepcea

DIOPT Version :9

Sequence 1:	NP_001260724.1	Gene:	bin3 / 35552	FlyBaseID:	FBgn0263144	Length:	1367	Species:	Drosophila melanogaster
Sequence 2:	NP_001122001.1	Gene:	mepcea / 561384	ZFINID:	ZDB-GENE-030131-3936	Length:	701	Species:	Danio rerio

Alignment Length:	927	Identity:	241/927 - (25%)
Similarity:	357/927 - (38%)	Gaps:	308/927 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 AGNNANHTCCLVTGCNGSSIGGVGVAGSGGATASAGGGGASCKEAQSCKDTSSLSGNSSIAGSAG 279
            ||:.|:......|..|.||...|    .|..::.....|...::.:..|..:::|     ||...
Zfish    48 AGSEASLEKSATTDNNASSESAV----LGAESSKQSHNGTKPQQQKVNKRRNTMS-----AGFKH 103

  Fly   280 AGNAVHYCCGRSKFFLPEKRLRK----EVIVPPTKFLLGGNISDPLNLNSLQNENTSNASSTNNT 340
            .|..              ||.|:    ...|.||.|||||||.||||||||.:|..:.|.:
Zfish   104 PGYG--------------KRRRRANSESESVLPTNFLLGGNIFDPLNLNSLLDEEVNKALN---- 150

  Fly   341 PATTPRQSPITTPPK----VEVIIPPNIHDPLHL--LDPVDSMEYEKQLTSPMKRAGPGGGMLHH 399
             |.||:.||:  |.|    ||::||.:|.|||:|  |...||:     |.||:|   .|||...|
Zfish   151 -AETPKSSPL--PAKNRDPVEILIPRDITDPLNLNCLSTGDSL-----LVSPLK---SGGGRRRH 204

  Fly   400 RQHHYRTRKNRKRRRFDSNNTSHAGDEGGVGSELTDEPPLPAATSSLAASPVAAPLNVGGSLLLS 464
            |..|:            ..||.....| |:|               |..|...|.:...|:.|:|
Zfish   205 RNKHH------------GANTGRVSTE-GIG---------------LTESNGCAAVKDDGTSLVS 241

  Fly   465 ESAAPAPGETAEMGQQQEQAHVHSPQSASTTTTAAEMPTPTPTSAAAATATAEHKEQSAPAPT-A 528
            .:........|:  |....:.:.|...:|.|:...|:...| ...:.|..||.        || .
Zfish   242 MTNVHLESTIAD--QTLLDSTLESSNKSSLTSNDNEVKEKT-VDCSTAHLTAN--------PTNP 295

  Fly   529 TSSPQRQQQHVAAAAEELPTPETSAAAETPAEEMLLSCSATSASLVASTLAERRASRDLRLDLSS 593
            .||.||:::...:..|                      :::|:|.|      :|:.|..:.:.|.
Zfish   296 PSSRQRKRRRAGSRTE----------------------NSSSSSEV------KRSGRHFQHNESQ 332

  Fly   594 TCYGVGGTGLSFGGSISSSVGSSFGGGGRKRKISESSTSQKSKKFHRHDAMDKIVSPVVPQPGAW 658
                        ||:                  |.|..|.:.:                |.|..|
Zfish   333 ------------GGN------------------SRSGVSDRQQ----------------PYPNQW 351

  Fly   659 KRPPRILQPSGARKPSTRRSTSVSESELLSPVEEQPPKQLPLIGVEIPRDDTPDLPDHGLGSPLS 723
             ||    |.|.                     ..|.|:|
Zfish   352 -RP----QYSN---------------------NNQNPQQ-------------------------- 364

  Fly   724 TTSGATSHTAGEQDSLAGVDISMGDTLGSGVVGKAPLTSSLMLEPAKIPPIKMLPKFRADGLKYR 788
                                                        |.|               |::
Zfish   365 --------------------------------------------PKK---------------KFQ 370

  Fly   789 YGNFDRYVDFRQMNEFRDVRLQVFQRHVELFENKDILDIGCNVGHMTITVARHLAPKTIVGIDID 853
            |||:::|..:|......|.|::|.  :.:.|..||:||:|||.||:|:.:|::..|.:|||:|||
Zfish   371 YGNYNKYYGYRNPGMSEDPRIRVM--NPDWFRGKDVLDLGCNTGHLTLFIAKNWRPASIVGLDID 433

  Fly   854 RELVARARRNLSIFVRIPKEEKLLEVKAEPTVDAKANI-AVKDETSGAAHKKTRRG-----KRRR 912
            ..|:..||:|:..:        |.||:.:.:..:..|. |.:.|.||....|.:..     |:.:
Zfish   434 GSLIHAARQNIRHY--------LSEVQVQHSRRSGENTKADRGEVSGEEKDKDKTSLVMDEKKAK 490

  Fly   913 KV-------HQGIHHHHHHHHDLEQLQQQQKLNSLLVKPHEFFPISFPLTYGRI-----PRILSS 965
            .|       .:|:..:.....:.::.:.....:..|......||:|..::.|.|     |...:.
Zfish   491 HVDEVNKCMDEGMEVNQEEKREADRGEIGDGASVDLPDGKHSFPVSLRISRGPIAGPPLPETNTH 555

  Fly   966 SKSPNMLGNKNQFPANVFFRHTNYVLKDESLMASDTQQYDLILCLSVTKWIHLNFGDNGLKMAFK 1030
            |..|      ..|||||.|...||||:.:.|:.:..::||:|||||||||:|||:||.|||..|.
Zfish   556 SLPP------GDFPANVTFIKGNYVLESDVLLQTQREEYDVILCLSVTKWVHLNWGDAGLKRFFH 614

  Fly  1031 RMFNQLRPGGKLILEAQNWASYKKKKNLTPEIYNNYKQIEFFPNKFHEYLLSSEVGFSHSYTLGV 1095
            |::..|||||..|||.|.|:||.|:|.||..|..||..|...|::|..: |::|||||....:|.
Zfish   615 RVYKHLRPGGLFILEPQPWSSYNKRKKLTEAICKNYHSIRLKPDQFSSF-LTTEVGFSSYELIGT 678

  Fly  1096 PRHMNKGFCRPIQLYAK 1112
            .::.:|||.|||.||.|
Zfish   679 SQNYSKGFQRPISLYHK 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bin3	NP_001260724.1	Methyltransf_18	820..>867	CDD:289607	22/46 (48%)
bin3	NP_001260724.1	Bin3	1004..1112	CDD:284317	58/107 (54%)
mepcea	NP_001122001.1	Methyltransf_25	404..>455	CDD:316196	23/58 (40%)
mepcea	NP_001122001.1	Bin3	588..695	CDD:311052	58/107 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589285
Domainoid	1	1.000	124	1.000	Domainoid score	I5449
eggNOG	1	0.900	-	-		E1_KOG2899
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I2992
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185441at2759
OrthoFinder	1	1.000	-	-		FOG0003359
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103556
Panther	1	1.100	-	-	LDO	PTHR12315
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2246
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760