Protein Alignment bin3 and Mepce

DIOPT Version :10

• Sequence 1: NP_523626.2
• Gene: bin3 / 35552
• FlyBaseID: FBgn0263144
• Length: 1367
• Species: Drosophila melanogaster
• Sequence 2: XP_017176362.1
• Gene: Mepce / 231803
• MGIID: 106477
• Length: 710
• Species: Mus musculus
• Alignment Length: 1007
• Identity: 237/1007 - (23%)
• Similarity: 348/1007 - (34%)
• Gaps: 399/1007 - (39%)

  Fly   160 GGGGG--AGAHHAAAGGH-----HHHHNTRLAQNAAAGGASGGGTIQMHKKMLRGHHHHVLCAGN 217
            |||||  ..:|..||.|.     .|....|.....||....||...|.|     |..|.
Mouse    25 GGGGGPEVQSHQEAASGELRDGTEHGPGPRAHSAGAAASGGGGPQAQAH-----GEPHG------ 78

  Fly   218 NANHTCCLVTGCNGSSIGGVGVAGSGGATASAG-----------------GGGASCKEAQSCKDT 265
                        ..::...||....||.....|                 |||.. |...||
Mouse    79 ------------RAAAPADVGEERRGGGGTDLGPPAPPRPRNGYQPHRPPGGGGG-KRRNSC--- 127

  Fly   266 SSLSGNSSIAGSAGAGNAVHYCCGRSKFFLPEKRLRKEV-----IVPPTKFLLGGNISDPLNLNS 325
                   ::.|.:| |:..|          |..:.|:.|     .|.|:.|||||||.|||||||
Mouse   128 -------NVGGGSG-GSFKH----------PAFKRRRRVNSDCDSVLPSNFLLGGNIFDPLNLNS 174

  Fly   326 LQNENTSNASSTNNTPATTPRQSPITTPPK----VEVIIPPNIHDPLHLLDPVDSMEYEKQLTSP 386
            |.:|..|.|.:     |.||:.||:  |.|    ||::||.:|.|||.|....|  |....|.||
Mouse   175 LLDEEVSRALN-----AETPKSSPL--PAKGRDPVEILIPKDITDPLSLNTCTD--EAHVVLASP 230

  Fly   387 MKRAGPGGGMLHHRQHHYRTRKNRKRRRFDSNNTSHAGDEGGVGSELTDEPPLPAATSSLAASPV 451
            :|        :..::|.:|...::::::....|.|:|                    :.|...|:
Mouse   231 LK--------IGRKRHRHRGPHHQQQQQASGGNDSNA--------------------AVLPTDPL 267

  Fly   452 AAPLNVGGSLLLSESAAPAPGETAEMGQQQEQAHVHSPQSASTTTT---AAEMPTPTPTSAAAAT 513
            ...|:               ||.|...||....:..:||.....|.   ..|:.:|.|::...::
Mouse   268 TPSLH---------------GEGATQQQQNRGQNRDAPQPYELNTAINCRDEVVSPLPSALQGSS 317

  Fly   514 ATAEHKEQSAPAPTATSSPQRQQQHVAAAAEELPTPETSAAAETPAEEMLLSCSATSASLVASTL 578
            .:.    .:.||.:.||:|.     .::::.......||:.:|..|.
Mouse   318 GSL----SAPPAASVTSAPS-----TSSSSRHRKRRRTSSKSEAGAR------------------ 355

  Fly   579 AERRASRDLRLDLSSTCYGVGGTGLSFGGSISSSVGSSFGGGGRKRKISESSTSQKSKKFHRHDA 643
                                       |||..|.......||||                |.|
Mouse   356 ---------------------------GGSQGSKEKGRGSGGGR----------------HHH-- 375

  Fly   644 MDKIVSPVVPQPGAWKRPPRILQPSGARKPSTRRSTSVSESELLSPVEEQPPKQLPLIGVEIPRD 708
                                                                             
Mouse   376 ----------------------------------------------------------------- 375

  Fly   709 DTPDLPDHGLGSPLSTTSGATSHTAGEQDSLAGVDISMGDTLGSGVVGKAPLTSSLMLEPAKIPP 773
                       .||..|.
Mouse   376 -----------HPLPATG----------------------------------------------- 382

  Fly   774 IKMLPKFRADGLKYRYGNFDRYVDFRQMNEFRDVRLQVFQRHVELFENKDILDIGCNVGHMTITV 838
                  |:...||::|||:.:|..:|..: ..||||:|.:  .|.|:.:|:||:||||||:|:::
Mouse   383 ------FKKQQLKFQYGNYCKYYGYRNPS-CEDVRLRVLK--PEWFQGRDVLDLGCNVGHLTLSI 438

  Fly   839 ARHLAPKTIVGIDIDRELVARARRNLSIFVRIPKEEKLLEVKAEPTVDAKANIAVKDETSGAAHK 903
            |....|..:||:|||..|:..||:|:..::   .||..|:.
Mouse   439 ACKWGPARMVGLDIDPRLIHSARQNIRHYL---SEELRLQA------------------------ 476

  Fly   904 KTRRGKRRRKVHQGIHHHHHHHHDLEQLQQQQKLNSLLVKPHEFFPISFPLTYGRIPRILSSSKS 968
            :|..|....:..:|                     ::.|:....||.|  ||..|.|  :::.:.
Mouse   477 QTSEGDPGTEGEEG---------------------TITVRKRSCFPAS--LTASRGP--IAAPQV 516

  Fly   969 PNMLGNKNQFPANVFFRHTNYVLKDESLMASDTQQYDLILCLSVTKWIHLNFGDNGLKMAFKRMF 1033
            |....:.:.||.||.|...||||..:.|:.:...:||::||.|:|||:|||:||.|||..|:|::
Mouse   517 PLDGADTSVFPNNVVFVTGNYVLDRDELVDAQRPEYDVVLCFSLTKWVHLNWGDEGLKRMFRRIY 581

  Fly  1034 NQLRPGGKLILEAQNWASYKKKKNLTPEIYNNYKQIEFFPNKFHEYLLSSEVGFSHSYTLGVPRH 1098
            ..|||||.|:||.|.|:||.|:|:||..||.||.:|:..|.:|..||.|.|||||....:..|.:
Mouse   582 RHLRPGGILVLEPQPWSSYCKRKSLTETIYKNYFRIQLKPEQFSSYLTSPEVGFSSYELVATPNN 646

  Fly  1099 MNKGFCRPIQLYAKGDY--TPNHVRWSDAYYP 1128
            .::|        .||.:  ......|...|.|
Mouse   647 TSRG--------KKGSFFWAGRGSSWLQGYRP 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bin3	NP_523626.2	PRK07764	<426..>559	CDD:236090	22/135 (16%)
		Cfa	783..>862	CDD:441831	33/78 (42%)
		Tam	824..>864	CDD:443282	19/39 (49%)
		Bin3	1004..1112	CDD:462022	51/107 (48%)
Mepce	XP_017176362.1	AdoMet_MTases	423..593	CDD:100107	70/221 (32%)
		Bin3	552..650	CDD:462022	50/97 (52%)