DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bin3 and Y17G7B.18

DIOPT Version :9

Sequence 1:	NP_001260724.1	Gene:	bin3 / 35552	FlyBaseID:	FBgn0263144	Length:	1367	Species:	Drosophila melanogaster
Sequence 2:	NP_001379028.1	Gene:	Y17G7B.18 / 174850	WormBaseID:	WBGene00012469	Length:	381	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	152/518 - (29%)
Similarity:	222/518 - (42%)	Gaps:	144/518 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   609 ISSSVGSSFGGGGRKRKISESSTSQKSKKFHRHDAMDKIVSPVVPQPGAWKRPPRILQPSGARKP 673
            :||....||  .||||...::.....||.    |.:: |...:...|...|:...:|.|:..|
Worm     1 MSSHRRGSF--RGRKRFYRDTFAPGGSKT----DPLN-IEIELTENPEEEKKRLGLLDPTTER-- 56

  Fly   674 STRRSTSVSE-SELLSPVEEQPPKQLPLIGVEIPRDDTPDLPDHGLGSPLSTTSGATSHTAGEQD 737
            |.:|.....| ||  .|.|..|.|:|.......||.|:...|                ..:.|:.
Worm    57 SKKRKVEKDEKSE--KPAENSPFKKLQKNQYNSPRKDSRRPP----------------QLSKEEK 103

  Fly   738 SLAGVDISMGDTLGSGVVGKAPLTSSLMLEPAKIPPIKMLPKFRADGLKYRYGNFDRYVDFRQMN 802
            |.|                          |..|       .|......||||||||||...|...
Worm   104 SAA--------------------------ENRK-------QKTEYFNKKYRYGNFDRYYGIRLNP 135

  Fly   803 EFRDVRLQVFQRHVELFENKDILDIGCNVGHMTITVARHLAPKTIVGIDIDRELVARARRNLSIF 867
            ...|.||.|||:  :.||:|..||||||.|.:|:::|:..:|:.|:|||||..|:..||:|:
Worm   136 GESDKRLSVFQK--DWFEHKQALDIGCNAGFLTLSIAKDFSPRRIIGIDIDEHLIGVARKNI--- 195

  Fly   868 VRIPKEEKLLEVKAEPTVDAKANIAVKDETSGAAHKKTRRGKRRRKVHQGIHHHHHHHHDLEQLQ 932
                                                                 .|:..|:.|...
Worm   196 -----------------------------------------------------RHYCDHETEVSG 207

  Fly   933 QQQKLNSLLVKPHEFFPISFPLTYGRIPRILSSSKSPNMLGNKNQFPANVFFRHTNYVLKDESLM 997
            :              ||.||.:.:|.:.:   .:::|.....|  ||.|::|:..||||:.:.::
Worm   208 K--------------FPASFGVQFGTVSQ---RNEAPRSFSTK--FPDNIWFKKENYVLESDEML 253

  Fly   998 ASDTQQYDLILCLSVTKWIHLNFGDNGLKMAFKRMFNQLRPGGKLILEAQNWASYKKKKNLTPEI 1062
            .....::|:||.||:|||||||:||:|::..|:|.:.||.|||:||:|.|.:.||||:..::.|:
Worm   254 DMIQPEFDVILALSITKWIHLNWGDDGMRRFFRRAYAQLHPGGRLIIEPQAFDSYKKRAKMSEEL 318

  Fly  1063 YNNYKQIEFFPNKFHEYLLSSEVGFSHSYTLGVPRHMNKGFCRPIQLYAKGDYTPNHVRWSDA 1125
            ..||.:|||.|..|..:|:.: |||.....|||....:|||.|||.:|.|    |.|.: :||
Worm   319 KANYSKIEFKPEDFEMWLIET-VGFESVEKLGVVGAKSKGFERPIDVYLK----PLHPK-TDA 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bin3	NP_001260724.1	Methyltransf_18	820..>867	CDD:289607	22/46 (48%)
bin3	NP_001260724.1	Bin3	1004..1112	CDD:284317	52/107 (49%)
Y17G7B.18	NP_001379028.1	Methyltransf_25	156..296	CDD:404528	58/214 (27%)
Y17G7B.18	NP_001379028.1	Bin3	260..367	CDD:399683	52/107 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163364
Domainoid	1	1.000	123	1.000	Domainoid score	I3452
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S5203
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185441at2759
OrthoFinder	1	1.000	-	-		FOG0003359
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103556
Panther	1	1.100	-	-	LDO	PTHR12315
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2246
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.800