Protein Alignment bin3 and bin3

DIOPT Version :10

• Sequence 1: NP_523626.2
• Gene: bin3 / 35552
• FlyBaseID: FBgn0263144
• Length: 1367
• Species: Drosophila melanogaster
• Sequence 2: XP_061516608.1
• Gene: bin3 / 1280586
• VectorBaseID: AGAMI1_010227
• Length: 1390
• Species: Anopheles gambiae
• Alignment Length: 1552
• Identity: 514/1552 - (33%)
• Similarity: 673/1552 - (43%)
• Gaps: 417/1552 - (26%)

  Fly    12 CRVTRSTMTPTLRLDQTSRQEPLPQQPDNGPAAAPGK---------------SKSPTPLPGKSQA 61
            |...|:...|...:           :|..|..|..|:               ::...|...:...
Mosquito    40 CNAHRAARPPNSMI-----------EPSGGGGAGKGRGGGGGGGGGGGGGNHNRKNNPQQQRHLQ 93

  Fly    62 AQHHQFRAPQQQQGPKNRNK--AWSKRQHK---AGGKHNPSACVGASSGQ--AQSTGSSVIAATL 119
            .|..|.:..||..|.|.:.|  .|...:::   :|||..|     |..|:  ..:.||..|.
Mosquito    94 QQQQQLQQQQQHGGGKKQKKQQKWKANKYRGRGSGGKDCP-----ARGGRKDKSAVGSQAIG--- 150

  Fly   120 LPTAASAHKADLENIQNIHNKNLTAGGGVNHHGNAGTAHHGGGGGAG-----AHHAAAGGHHHHH 179
                                 .:..|..||..|....      |.||     .|.|..|..|..|
Mosquito   151 ---------------------KMEEGNAVNGIGGEDL------GAAGLNVGETHPAEPGCFHQVH 188

  Fly   180 NTRLAQNAAAGGASGGGTIQMHKKMLRGHHHHVLCAGNNANHTCCLVTGCNGSSIGGVGVAGSGG 244
            ...||.::....:|..|:.|..::..:.........|:..:      :|..|...||   |||..
Mosquito   189 QQGLAHSSQLASSSSSGSAQQQQQQQQQQQQQQQSTGSQTS------SGATGQQQGG---AGSNM 244

  Fly   245 ATASAGGGGASCKEAQSCKDTSSLSGNSSIAGSAGAGNAVHYCCGRSKFFLPEKRLRKEVIVPPT 309
            ..:||.....:....|  ::.:.:...:....|.            ||||||:||.|||.|||||
Mosquito   245 MMSSAMPPQKNKHPKQ--QNLTPMEVRNKRLQSV------------SKFFLPDKRPRKECIVPPT 295

  Fly   310 KFLLGGNISDPLNLNSLQNENTSNASSTNNTPATTPRQSPITTPP----KVEVIIPPNIHDPLHL 370
            ||||||||||||||||||||:.:         |.||:.|||.|||    |:||||||||:|||||
Mosquito   296 KFLLGGNISDPLNLNSLQNESEN---------AVTPKSSPIPTPPHYKAKIEVIIPPNINDPLHL 351

  Fly   371 LDPVDSMEYEKQLTSPMKRAGPGGGMLHHRQHHYRTRKNRKRRRFDSNNTSHAGDEGGVGSELTD 435
            ||||||:|||.||.|||||             ..|.|..|||:   |..|:...| |.:..|...
Mosquito   352 LDPVDSVEYEMQLCSPMKR-------------KQRPRNKRKRK---SRTTTERND-GLLSIEQLP 399

  Fly   436 EPPLP----AATSSLAASPVAAPLNVGGSLLLSESAAPAPGETAEMGQQQEQAHVHSPQSASTTT 496
            .|||.    ..|||.|||..... ..||.:......|....|.:..|..|:.|      .|:...
Mosquito   400 PPPLGGEELVGTSSGAASGGGGG-GAGGGVAADAEEATTAEEASFTGIGQKLA------DAAAGE 457

  Fly   497 TAAEMPTPTPTSAAAATATAEHKEQ---SAPAPTATSSPQRQQQHV----AAAAEELPTPETSAA 554
            ....:|.|...:.:|....|....|   |...|.|.||...||.||    .||..|.|
Mosquito   458 QRFSLPVPDADTGSAHFHLAHFSGQPSTSGTGPVAASSSSVQQGHVHHVSGAAVMERP------- 515

  Fly   555 AETPAEEMLLSCSATSASLVASTLAER-RASRDLRLDLSSTCYGVGGTGLSFGGSISSSVGSSFG 618
                        .:::..|:.....|| |..|:|:|||.|
Mosquito   516 ------------GSSAGGLLTEQERERDRVMRNLKLDLES------------------------- 543

  Fly   619 GGGRKRKISESSTSQKSKKFHRHDAMDKIVSPVVPQPGAWKRP--PRILQPSGARKPSTRRSTSV 681
            .|||||:.|||:.|.|: |..|.|:||||||||:||||.|||.  |.....|||...:.|..|..
Mosquito   544 AGGRKRRTSESTNSTKN-KLRRMDSMDKIVSPVIPQPGGWKRAHWPANAGGSGAAGSAGRNRTRT 607

  Fly   682 SESELLSPVEEQPPKQLPLIGVEIPRDDTPDLPDHGLGSPLST-------------------TSG 727
            ..:  .|..:||                      ||....::|                   |.|
Mosquito   608 FST--TSVTDEQ----------------------HGEDGTIATGADRSTEGQAQEKAHKTERTDG 648

  Fly   728 ATSH--TAGEQ---------DSLAGVDISMGDTLGSGVVG-KAPLTSSLMLEPAKIPPIKMLPKF 780
            ...|  .||::         .:.|.|..:....:|||:.. :.||:.:.......:||.:   ..
Mosquito   649 LEDHKKQAGDEGGAVKEEGRSNEANVMGTSAGRMGSGIGSIERPLSLTQGTSQGTVPPSQ---SS 710

  Fly   781 RADGLKYRYGNFDRYVDFRQMNEFRDVRLQVFQRHVELFENKDILDIGCNVGHMTITVARHLAPK 845
            .|...:|.:||:|||..:..:|||.||||:||.|:..||.:||:||||||||.|||.:|:.|..|
Mosquito   711 LAATSRYHFGNYDRYYGYHSLNEFIDVRLKVFMRNAYLFRDKDVLDIGCNVGLMTIAIAKSLHTK 775

  Fly   846 TIVGIDIDRELVARARRNLSIFVRIPK---------------------------------EEKLL 877
            :.:|||:|.:|:|:||:||:.:||:|:                                 .::.|
Mosquito   776 SAIGIDVDGKLIAKARKNLAKYVRVPRTVVPGAGRRGHRESSTVVSATVTKMEVSEELATSKETL 840

  Fly   878 EVKAEPTVDA-----------------------------KANIA-VKDETSGAAHKKT------- 905
            .::::|...|                             .|::| .:|..|||..::|
Mosquito   841 PLQSDPAPTAVSAPQPSTSQEGGECTEPSAATPVAVPTPPASVAETEDNVSGAPVEETVTQMVTP 905

  Fly   906 -----------------------------RRGKRRRK--VHQGIHHHHHHHHDLEQLQQQQKLNS 939
                                         .|.|||||  ..:|..|..||:....|..||..|..
Mosquito   906 AAASNEDAEKAPPEPPAIAVPAETSNRVVARQKRRRKRFGQKGGRHGQHHNSQHHQQHQQHHLRR 970

  Fly   940 LLVKPHEFFPISFPLTYGRIPRILSSSKSPNM-LGN-KNQFPANVFFRHTNYVLKDESLMASDTQ 1002
            ...:..::||||||:|.|..     |.|...| :|. :|:||.||.|:..|||||||.::..|||
Mosquito   971 NKPEQSQYFPISFPVTMGNF-----SGKEHQMDIGRPENKFPNNVRFKTMNYVLKDEQMINFDTQ 1030

  Fly  1003 QYDLILCLSVTKWIHLNFGDNGLKMAFKRMFNQLRPGGKLILEAQNWASYKKKKNLTPEIYNNYK 1067
            |||||||||||||||||:||.|||.|||||||.|||||||||||||||||||||.||..|:.||:
Mosquito  1031 QYDLILCLSVTKWIHLNYGDVGLKTAFKRMFNHLRPGGKLILEAQNWASYKKKKKLTETIFENYQ 1095

  Fly  1068 QIEFFPNKFHEYLLSSEVGFSHSYTLGVPRHMNKGFCRPIQLYAKGDYTPNHVRWSDAYYPQTPY 1132
            :|||||..||:||||.|||||||:.||:|||::|||.||||||.|||:||:..:|||.|:|.|||
Mosquito  1096 KIEFFPKYFHDYLLSPEVGFSHSFPLGIPRHLSKGFRRPIQLYIKGDFTPSQAKWSDTYHPGTPY 1160

  Fly  1133 EAYRGIYATLPVHRMGGGGSSAGGSNSGHAQMLHLSSSSRSQNYDTPHYAGSASGSASCRQTPMY 1197
            |.:||||..:..     ...||.|...| |...:..|.|..|.....|..||..||.....|
Mosquito  1161 ENHRGIYTDIVT-----ASQSAAGCIWG-AMTPYAPSYSYRQPPTPSHGGGSGGGSGGFAST--- 1216

  Fly  1198 QPTYNPLETDSYQPSYDMEYLNH--MYVFASPLYQTVWSPPA-----------SLRKSSSHTPVF 1249
            .|.|||.:||||.||||:...:.  .|.||||:|.|.||||:           |.|:|:|:||..
Mosquito  1217 SPYYNPRQTDSYLPSYDIANTHRPGSYCFASPIYSTTWSPPSDMLATSGGGGGSYRRSASNTPNS 1281

  Fly  1250 GSVRDAELDGDGSGGGGSGGGSYHR-HVYPPND--------DTCSPNA---------NACNAFNS 1296
            .|:|..:.|........|||.|..| |||||.:        |...|::         .......:
Mosquito  1282 ASIRSVDNDDHYYVSTASGGSSQRRHHVYPPIEVFAPLHGYDAMRPSSYRSGNGAGGGGGGGGGA 1346

  Fly  1297 IRDADTDDSNQLPGGSRRHVYATNCGESSSSPQVNHHDAVGEFVDGLMDDEQKSSTG 1353
            |.|:|::.|:                .|:|..........|.|   |.||:..|.:|
Mosquito  1347 ITDSDSELSS----------------HSASQTPTRQQQLAGSF---LTDDQSNSPSG 1384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bin3	NP_523626.2	PRK07764	<426..>559	CDD:236090	37/143 (26%)
		Cfa	783..>862	CDD:441831	41/78 (53%)
		Tam	824..>864	CDD:443282	22/39 (56%)
		Bin3	1004..1112	CDD:462022	86/107 (80%)
bin3	XP_061516608.1	None