DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30431 and ZNF142

DIOPT Version :9

Sequence 1:	NP_610211.1	Gene:	CG30431 / 35549	FlyBaseID:	FBgn0050431	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001353219.1	Gene:	ZNF142 / 7701	HGNCID:	12927	Length:	1887	Species:	Homo sapiens

Alignment Length:	595	Identity:	127/595 - (21%)
Similarity:	185/595 - (31%)	Gaps:	250/595 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PHHPLVCR------------CCLLEQPPLYHSLYDASSQLAVELK------------ALAPALRL 46
            |..|..|:            |.|.|...|:.||...::..|..|:            |..|...|
Human  1307 PTCPFSCQQERALRTHQIRGCPLEESGELHCSLCPFTAPAATALRLHQKRRHPTAAPARGPRPHL 1371

  Fly    47 EHGDNLTDVICDLCLRRLHDARDFQRRCEHSEQVLRMRHEHWK-HTVAVGDALALDDVLEC---- 106
            :.||      |....:        |.||  .:|..|::||..| |              :|
Human  1372 QCGD------CGFTCK--------QSRC--MQQHRRLKHEGVKPH--------------QCPFCD 1406

  Fly   107 --------LEREVGSLEGPMSVPLQA-------------------SKPVAHVAPLMETVDFESLD 144
                    ||.......|...:|..:                   .|...|..||.:.
Human  1407 FSTTRRYRLEAHQSRHTGIGRIPCSSCPQTFGTNSKLRLHRLRVHDKTPTHFCPLCDY------- 1464

  Fly   145 FQDSSHSEHDIPSYWESSVDSGSLNTP----------------------HHQPETAELFAVEPPT 187
               |.:..|||..:    |:|....||                      ...||.|:   ..|.:
Human  1465 ---SGYLRHDITRH----VNSCHQGTPAFACSQCEAQFSSETALKQHALRRHPEPAQ---PAPGS 1519

  Fly   188 PPESSEEP---------APDAA--------EKPKM------------------RR---------- 207
            |.|::|.|         .|..|        :.|::                  ||
Human  1520 PAETTEGPLHCSRCGLLCPSPASLRGHTRKQHPRLECGACQEAFPSRLALDEHRRQQHFSHRCQL 1584

  Fly   208 ----ARPRQDNVK---PKERKASGAVHPRS---------LHPCPECEKKFTRNFQLKL-HMTAVH 255
                ||.|...||   .:..:.|.||....         || ||.|:  ||...||.| |....|
Human  1585 CDFAARERVGLVKHYLEQHEETSAAVAASDGDGDAGQPPLH-CPFCD--FTCRHQLVLDHHVKGH 1646

  Fly   256 GMGEMRYQCEECRKNFASRHSLRYHVKSVHSTERPFGCQHC-------------------DRRFI 301
            | |...|:|.:|..:..:|..:.:|.: :|:.|:|:.|..|                   :|:::
Human  1647 G-GTRLYKCTDCAYSTKNRQKITWHSR-IHTGEKPYHCHLCPYACADPSRLKYHMRIHKEERKYL 1709

  Fly   302 LR---------TQLLSHLRTHTGEAKP---------------------------RIFECQRCSKS 330
            ..         .||..|:..||| .||                           |.|.|::|.|:
Human  1710 CPECGYKCKWVNQLKYHMTKHTG-LKPYQCPECEYCTNRADALRVHQETRHREARAFMCEQCGKA 1773

  Fly   331 WPTKSDLRTHMRSHNPNMERPFKCDRCSKAFFTRGHLNSHLLVHTGEKPFACEYCDKCYQSVGNL 395
            :.|:..||||:|.|:.  .:|:.|:.|.:||.....|..|.|.||...||.|..|:...:....:
Human  1774 FKTRFLLRTHLRKHSE--AKPYVCNVCHRAFRWAAGLRHHALTHTDRHPFFCRLCNYKAKQKFQV 1836

  Fly   396 NNHMVRLHAD 405
            ..|:.|.|.|
Human  1837 VKHVRRHHPD 1846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30431	NP_610211.1	zf-AD	11..82	CDD:285071	19/94 (20%)
		C2H2 Zn finger	234..255	CDD:275368	9/21 (43%)
		C2H2 Zn finger	264..285	CDD:275368	4/20 (20%)
		C2H2 Zn finger	293..313	CDD:275368	6/47 (13%)
		zf-C2H2_8	305..373	CDD:292531	27/94 (29%)
		C2H2 Zn finger	324..344	CDD:275368	9/19 (47%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		zf-H2C2_2	366..389	CDD:290200	9/22 (41%)
		C2H2 Zn finger	382..403	CDD:275368	4/20 (20%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368
		C2H2 Zn finger	393..413	CDD:275368
		C2H2 Zn finger	421..438	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	545..566	CDD:275368
		C2H2 Zn finger	574..595	CDD:275368
		zf-H2C2_5	601..625	CDD:404746
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	687..707	CDD:275368
		C2H2 Zn finger	714..731	CDD:275368
		PHA03247	928..>1219	CDD:223021
		C2H2 Zn finger	1306..1353	CDD:275368	11/45 (24%)
		C2H2 Zn finger	1373..1394	CDD:275368	8/36 (22%)
		C2H2 Zn finger	1402..1422	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1430..1451	CDD:275368	0/20 (0%)
		C2H2 Zn finger	1626..1646	CDD:275368	9/21 (43%)
		C2H2 Zn finger	1654..1674	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1682..1702	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1710..1730	CDD:275368	3/19 (16%)
		zf-H2C2_2	1723..1747	CDD:404364	7/24 (29%)
		C2H2 Zn finger	1738..1759	CDD:275368	0/20 (0%)
		C2H2 Zn finger	1767..1787	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1795..1815	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1823..1843	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100