DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30431 and ZNF25

DIOPT Version :9

Sequence 1:	NP_610211.1	Gene:	CG30431 / 35549	FlyBaseID:	FBgn0050431	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001316576.1	Gene:	ZNF25 / 219749	HGNCID:	13043	Length:	460	Species:	Homo sapiens

Alignment Length:	344	Identity:	99/344 - (28%)
Similarity:	148/344 - (43%)	Gaps:	41/344 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 VLRMRHEHWKHTVAVGDALALDDVLECLEREVGSLEGPMSVPLQASKPVA------HVAPLMETV 138
            ::....|.||........|..|.:||.....|       ||....:||.|      ...|.:..|
Human    18 IVEFTKEEWKLLTPAQRTLYKDVMLENYSHLV-------SVGYHVNKPNAVFKLKQGKEPWILEV 75

  Fly   139 DFESLDFQDSSHSEHDIPSYWESSVDSGSLN---TPHHQPETAE----------LFAVEPPTPPE 190
            :|....|.:...|.||:.:.::.|....|.|   |.|.:..|.|          .|..:......
Human    76 EFPHRGFPEDLWSIHDLEARYQESQAGNSRNGELTKHQKTHTTEKACECKECGKFFCQKSALIVH 140

  Fly   191 SSEEPAPDAAEKPKMRRARPRQDNVKPKERKASGAVHPR-SLHPCPECEKKFTRNFQLKLHMTAV 254
            ........:.:..|..::..:.:::...::     :|.| ..:.|.||:|.|.....|..|: ..
Human   141 QHTHSKGKSYDCDKCGKSFSKNEDLIRHQK-----IHTRDKTYECKECKKIFYHLSSLSRHL-RT 199

  Fly   255 HGMGEMRYQCEECRKNFASRHSLRYHVKSVHSTERPFGCQHCDRRFILRTQLLSHLRTHTGEAKP 319
            |. ||..|:|.:|.|:|..:..|..|.|: |:.|:||.|..|.:.|.::..|:.|.:||||| ||
Human   200 HA-GEKPYECNQCEKSFYQKPHLTEHQKT-HTGEKPFECTECGKFFYVKAYLMVHQKTHTGE-KP 261

  Fly   320 RIFECQRCSKSWPTKSDLRTHMRSHNPNMERPFKCDRCSKAFFTRGHLNSHLLVHTGEKPFACEY 384
              :||:.|.|::..||.|..|.|.|..  |:|:||..|.|.|....||.:|...||||||:.|:.
Human   262 --YECKECGKAFSQKSHLTVHQRMHTG--EKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYECKE 322

  Fly   385 CDKCYQSVGNLNNHMVRLH 403
            |.||:.....|..|. |.|
Human   323 CRKCFYQKSALTVHQ-RTH 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30431	NP_610211.1	zf-AD	11..82	CDD:285071	0/1 (0%)
		C2H2 Zn finger	234..255	CDD:275368	7/20 (35%)
		C2H2 Zn finger	264..285	CDD:275368	7/20 (35%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		zf-C2H2_8	305..373	CDD:292531	29/67 (43%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		zf-H2C2_2	366..389	CDD:290200	12/22 (55%)
		C2H2 Zn finger	382..403	CDD:275368	7/20 (35%)
ZNF25	NP_001316576.1	KRAB	12..72	CDD:214630	14/60 (23%)
		KRAB	12..51	CDD:279668	8/39 (21%)
		C2H2 Zn finger	124..144	CDD:275368	1/19 (5%)
		COG5048	148..457	CDD:227381	71/207 (34%)
		C2H2 Zn finger	152..172	CDD:275368	1/24 (4%)
		C2H2 Zn finger	180..200	CDD:275368	7/20 (35%)
		zf-H2C2_2	192..215	CDD:290200	9/24 (38%)
		C2H2 Zn finger	208..228	CDD:275368	7/20 (35%)
		zf-H2C2_2	220..243	CDD:290200	9/23 (39%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		zf-H2C2_2	248..273	CDD:290200	13/27 (48%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		zf-H2C2_2	276..301	CDD:290200	11/26 (42%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	304..327	CDD:290200	12/22 (55%)
		C2H2 Zn finger	320..340	CDD:275368	7/20 (35%)
		zf-H2C2_2	332..357	CDD:290200	4/10 (40%)
		C2H2 Zn finger	348..368	CDD:275368
		zf-H2C2_2	360..384	CDD:290200
		C2H2 Zn finger	376..396	CDD:275368
		zf-H2C2_2	389..413	CDD:290200
		C2H2 Zn finger	404..424	CDD:275368
		C2H2 Zn finger	432..452	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910