DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3f2 and EIF3F

DIOPT Version :9

Sequence 1:	NP_610210.2	Gene:	eIF3f2 / 35547	FlyBaseID:	FBgn0033069	Length:	286	Species:	Drosophila melanogaster
Sequence 2:	NP_003745.1	Gene:	EIF3F / 8665	HGNCID:	3275	Length:	357	Species:	Homo sapiens

Alignment Length:	277	Identity:	103/277 - (37%)
Similarity:	163/277 - (58%)	Gaps:	22/277 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VYLKPLVFFQIIDAYDRRPKGDNQVMGTLLGRNKEGHIEITNCFTVPHKEHSENKRIDLDMAYAS 76
            |.|.|::...|:|:|:||.:|..:|:|||||...:..:|:||||:|||.| ||:: :.:||.:|.
Human    92 VRLHPVILASIVDSYERRNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNE-SEDE-VAVDMEFAK 154

  Fly    77 EVLELNMFAYPNERVLGWFCTGKSVSRSASLIHDYYVRECCEGQPLHLLVDAALKNQRLSTRLYC 141
            .:.||:....|||.:|||:.||..::..:.|||:||.||.  ..|:||.||.:|:|.|:|.:.|.
Human   155 NMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREA--PNPIHLTVDTSLQNGRMSIKAYV 217

  Fly   142 AVEMGVPGGTKGLMFSLVPLEISNENSDLVALRCIEKQSQQQASKQMERFVP--------ELAQV 198
            :..|||||.|.|:||:.:.::.:..:::.:.:..|.|..          |.|        :|.||
Human   218 STLMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMKTC----------FSPNRVIGLSSDLQQV 272

  Fly   199 VDATRDMQHRLDLVLRYINDVLARKKKPDNVVGRSLYAALTAVPLLDSDKFRVMFNTNLRDMLMA 263
            ..|:..:|..|..||:|..|||:.|...||.|||.|.:.:..||.:..|.|..|.|:|:.|:||.
Human   273 GGASARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMV 337

  Fly   264 ITLSTMIKTQLEISEKL 280
            ..|:.:.::|:.::|||
Human   338 TYLANLTQSQIALNEKL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3f2	NP_610210.2	MPN_eIF3f	12..280	CDD:163695	101/275 (37%)
EIF3F	NP_003745.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82
EIF3F	NP_003745.1	MPN_eIF3f	92..354	CDD:163695	101/275 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147332
Domainoid	1	1.000	82	1.000	Domainoid score	I8417
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54712
OrthoDB	1	1.010	-	-		D1038775at2759
OrthoFinder	1	1.000	-	-		FOG0004972
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10540
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3506
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.960