DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3f2 and STAMBPL1

DIOPT Version :9

Sequence 1:	NP_610210.2	Gene:	eIF3f2 / 35547	FlyBaseID:	FBgn0033069	Length:	286	Species:	Drosophila melanogaster
Sequence 2:	NP_065850.1	Gene:	STAMBPL1 / 57559	HGNCID:	24105	Length:	436	Species:	Homo sapiens

Alignment Length:	290	Identity:	55/290 - (18%)
Similarity:	96/290 - (33%)	Gaps:	86/290 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMSRNFSMRAKVYLKPLVFFQIIDA--------------------YDRRPKGDNQVMGTLLGRNK 45
            :.|:| ..:|:: ||.|...::|:|                    ::.:.|......|.:..:..
Human   137 LQSKN-KYKAEI-LKKLEHQRLIEAERKRIAQMRQQQLESEQFLFFEDQLKKQELARGQMRSQQT 199

  Fly    46 EGHIE-----ITNCFTV-------------PHKEHSENKRIDLDMAYASEVLELN--------MF 84
            .|..|     ..:||:.             |:|..:.|        |||....:|        :.
Human   200 SGLSEQIDGSALSCFSTHQNNSLLNVFADQPNKSDATN--------YASHSPPVNRALTPAATLS 256

  Fly    85 AYPNERVLGWFCTGKSVSRSASLIHDYYVRECCEGQPLHLLVDAALKNQRLSTRLYCAVEMGVPG 149
            |..|..|.|..|    |.....|.|.:.  :..|...:..:....:...:|:...:....:.||.
Human   257 AVQNLVVEGLRC----VVLPEDLCHKFL--QLAESNTVRGIETCGILCGKLTHNEFTITHVIVPK 315

  Fly   150 GTKGL----MFSLVPLEISNENSDLVALRCIEKQSQQQA-----------SKQMERFVPELAQVV 199
            .:.|.    |.::..|....:..||:.|..|.....|.|           |.|:  .:||...:|
Human   316 QSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSVDLHTHCSYQL--MLPEAIAIV 378

  Fly   200 DATRDMQHRLDLVLRYIN----DVLARKKK 225
            .:.:   |:...:.|..|    :|.|.|||
Human   379 CSPK---HKDTGIFRLTNAGMLEVSACKKK 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3f2	NP_610210.2	MPN_eIF3f	12..280	CDD:163695	52/279 (19%)
STAMBPL1	NP_065850.1	USP8_dimer	28..129	CDD:286108
		GBP_C	<120..198	CDD:303769	10/62 (16%)
		MPN_AMSH_like	266..436	CDD:163697	30/151 (20%)
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	347..360		2/12 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900