Protein Alignment eIF3f2 and COPS6

DIOPT Version :10

• Sequence 1: NP_610210.2
• Gene: eIF3f2 / 35547
• FlyBaseID: FBgn0033069
• Length: 286
• Species: Drosophila melanogaster
• Sequence 2: NP_006824.2
• Gene: COPS6 / 10980
• HGNCID: 21749
• Length: 327
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 64/269 - (23%)
• Similarity: 119/269 - (44%)
• Gaps: 19/269 - (7%)

  Fly    12 VYLKPLVFFQIIDAYDR------RPKGDNQVMGTLLGRNKEGHIEITNCFTVPHKEHSENKRIDL 70
            |.|.|||...|.|.:.|      ||.   ||:|.|:|:.:..:||:.|.|.:  ..|:..::|.:
Human    41 VALHPLVILNISDHWIRMRSQEGRPV---QVIGALIGKQEGRNIEVMNSFEL--LSHTVEEKIII 100

  Fly    71 DMAYASEVLELNMFAYPNERVLGWFCTGKSVSRSASLIHDYYVRECCE--GQPLHLLVDAALKNQ 133
            |..|.....|.....:.....|||:.||.....|...:|    ::.||  ..||.|.::...|:.
Human   101 DKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVH----KQVCEIIESPLFLKLNPMTKHT 161

  Fly   134 RLSTRLYCAVEMGVPGGTKGLMFSLVPLEISNENSDLVALRCIEKQSQQQASKQMERFVPELAQV 198
            .|...::.:| :.:..|...::|:.:...::.|.::.:.:..:.:.: ...|.:.......|...
Human   162 DLPVSVFESV-IDIINGEATMLFAELTYTLATEEAERIGVDHVARMT-ATGSGENSTVAEHLIAQ 224

  Fly   199 VDATRDMQHRLDLVLRYINDVLARKKKPDNVVGRSLYAALTAVPLLDSDKFRVMFNTNLRDMLMA 263
            ..|.:.:..|:.|:|.|:....|.:...::.:.|..||....:|:|.:|||:..|.....|:.:.
Human   225 HSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLM 289

  Fly   264 ITLSTMIKT 272
            ..|.|:.||
Human   290 AYLGTITKT 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3f2	NP_610210.2	MPN_eIF3f	12..280	CDD:163695	64/269 (24%)
COPS6	NP_006824.2	MPN_CSN6	39..321	CDD:163694	64/269 (24%)
		Interaction with Vpr	211..327		22/88 (25%)