Protein Alignment Ptr and Ptch1

DIOPT Version :9

• Sequence 1: NP_001246145.1
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: XP_038952062.1
• Gene: Ptch1 / 89830
• RGDID: 621425
• Length: 1495
• Species: Rattus norvegicus
• Alignment Length: 1211
• Identity: 247/1211 - (20%)
• Similarity: 437/1211 - (36%)
• Gaps: 324/1211 - (26%)

  Fly   113 EVFQELRQLDNIIQNATTTYDGDTYTYKDNCARWENECFENDILN------------------LD 159
            |..:||::::         |..|::....|.|...:...:...||                  ||
  Rat   310 EFLEELKKIN---------YQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLD 365

  Fly   160 -ALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVFFGGTKLTEDNYVISVPAIQLVY---------- 213
             ||:  :..|...|:..:|.    |...|   ..|||.......::|..|:|.::
  Rat   366 VALV--LNGGCQGLSRKYMH----WQEEL---IVGGTVKNATGKLVSAHALQTMFQLMTPKQMYE 421

  Fly   214 ------FVTADTKRQDAKGA---EWEETFLRVVGN--AENSGQFKHISVSYFASRTLDHELEKNT 267
                  :|:.....:|...|   .|:.|::.||..  |.||.|    .|..|.:.|||..|:..:
  Rat   422 HFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQ----KVLSFTTTTLDDILKSFS 482

  Fly   268 KTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINL 332
            ...|...:|.:|||..::.:|.:..|..:|:..:||.|.:...::..|..||....||.|   |.
  Rat   483 DVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISF---NA 544

  Fly   333 AA----PFLMIGIGIDDTFVMLAGWRRT--KAKMPVAERMGLMMSEAAVSITITSVTDFISFLIG 391
            |.    |||.:|:|:||.|::...:..|  ..::|..:|.|..:.....|:.:||:::..:|.:.
  Rat   545 ATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMA 609

  Fly   392 IISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQP-MSVAIK--- 452
            .:.|..::|.|...:...|.|.|...:..|.|.:::..||.......||.|...| :|..|:
  Rat   610 ALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEP 674

  Fly   453 ------------------EKRNFLYK-------------------------------------AI 462
                              ...:|.::                                     .|
  Rat   675 QAYTEPHSNTRYSPPPPYSSHSFAHETHITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTI 739

  Fly   463 MAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVIN---NKW------------------CKAIIIL 506
            ....:....|::....:|  |::.|.|.....:.   .||                  .|.::||
  Rat   740 TQDTLSCQSPESTSSTRD--LLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVIL 802

  Fly   507 AFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLV 571
            .|...|..:.||.|::::||:...:...::...:|...:   ::.|.:....|:....:|  |.:
  Rat   803 LFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQ---FKYFSFYNMYIVTQKADY--PNI 862

  Fly   572 QEQVENLTSTLEHTSYV---TSRRYTESWLRSFLSFLE----------------RNN-------- 609
            |..:.:|..:.....||   .:::..:.||..|..:|:                .||
  Rat   863 QHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDG 927

  Fly   610 --------------ELLNVTVDDEQTFIDA------------------------------VKEH- 629
                          :.::::...:|..:||                              ::.|
  Rat   928 VLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHR 992

  Fly   630 --WLFPGNPFSLDVRFNEDETQIIA-SRFLIQAVNITDTNHEKEMVRDLRQICKD-SPLNASIF- 689
              |:.....:..:.|......:.|. ::|......:.||:...|.:..:|.||.: :.|..|.:
  Rat   993 PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYP 1057

  Fly   690 --HPYFVFFDQFELVRPVSLQAMVIGAI-IMMIISFVFIPNILCSLWVA------FSVISIELGV 745
              :| |:|::|:     :||:..::.|| :::..:|:.....|.:.|.|      .:::::||
  Rat  1058 NGYP-FLFWEQY-----ISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-- 1114

  Fly   746 AGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSS---KKRSPKARVREALHSLGLPIIQ 807
            .|.|.|..:.|.::.::.||..:|..|:||.|:...::::   |..    |...||..:..|::.
  Rat  1115 FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNH----RAMLALEHMFAPVLD 1175

  Fly   808 GSSSTILGIVALLLAQS---YIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCLTWTGKDD 869
            |:.||:||:  |:||.|   :|...||.::.::...|.::||.|||||||.|||  |      .:
  Rat  1176 GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGP--C------PE 1230

  Fly   870 GSDAEVDDGLDDRQLEKPFSQSYYMQYPSIGINGPYGSKGFLGAPYKAYGVDEK----DLGLGTS 930
            .|.|...:.|.....|.|.|...:...|....||...|.....:.....|:.|:    :...||.
  Rat  1231 VSPANGLNRLPTPSPEPPPSVVRFAVPPGHTNNGSDSSDSEYSSQTTVSGISEELRHYEAQQGTG 1295

  Fly   931 GEDSSESSSSRSQHRQQAAATEEEVVVRES---PTRRYDDGWRRSSYQNIYGQGAAQFQAQPDLY 992
            |          ..|:....|||..|..|.:   |..|:                      ||.|.
  Rat  1296 G----------PAHQVIVEATENPVFARSTVVHPDSRH----------------------QPPLN 1328

  Fly   993 GKQV------SATEWRQRLDTHEQQQRQRQRRSPFENYRQDVEIDMQKARRNSHGDVIDLHGTPN 1051
            .:|.      |.:..||.........|:..|..|:...|...||..:.....|:.|....||.
  Rat  1329 SRQQPHLDSGSLSPGRQGQQPRRDPPREGLRPPPYRPRRDAFEISTEGHSGPSNRDRSGPHGA-- 1391

  Fly  1052 SSVEERFRRRGEPFSAESGDDSSYRHQQIMAMPAAGSAPSA 1092
                 |......|.|...|.......|.|..:.|:.|...|
  Rat  1392 -----RSHNPRNPTSTAMGSSVPSYCQPITTVTASASVTVA 1427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	185/949 (19%)
		Sterol-sensing	295..442	CDD:289145	40/152 (26%)
Ptch1	XP_038952062.1	2A060602	178..1253	CDD:273338	204/996 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840