Protein Alignment Ptr and DISP2

DIOPT Version :9

• Sequence 1: NP_001246145.1
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_277045.1
• Gene: DISP2 / 85455
• HGNCID: 19712
• Length: 1401
• Species: Homo sapiens
• Alignment Length: 1114
• Identity: 210/1114 - (18%)
• Similarity: 359/1114 - (32%)
• Gaps: 363/1114 - (32%)

  Fly   143 CARWENECFEND--------ILNLDALMDDIEAGQL-NLTFPFMFNPVTWDAHLFPVFFGGTKLT 198
            ||:...:|.::.        :|:.|.|.......|: :|.:..:|.|....|.|..::.
Human   395 CAQVPTKCSQSSAIYQLLHFLLDRDFLSPQTTDYQVPSLKYSLLFLPTPKGASLMDIYL------ 453

  Fly   199 EDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHEL 263
                                    |.....|        |.|:|......:.:. .....|.|.|
Human   454 ------------------------DRLATPW--------GLADNYTSVTGMDLG-LKQELLRHFL 485

  Fly   264 EKNT-----KTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGN-VSAIMATLAAFGLAMY 322
            .::|     ..|..:|.....|..||  :|.|:        .||::|: :.|......||.:|.
Human   486 VQDTVYPLLALVAIFFGMALYLRSLF--LTLMV--------LLGVLGSLLVAFFLYQVAFRMAY- 539

  Fly   323 CGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMP---VAERMGLMMSEAAVSITITSVTD 384
                |..:||||..|:..:..:.|.:....||.:|:::|   :|:|:|..|......:.::.:|.
Human   540 ----FPFVNLAALLLLSSVCANHTLIFFDLWRLSKSQLPSGGLAQRVGRTMHHFGYLLLVSGLTT 600

  Fly   385 FISFLIGIISPFRSVRIFCTYSVFAV----CFTFLW-------HITFFAACMA------ISGYRE 432
            ..:|....:|...:||....:...||    ..|.:|       |..:.|...|      ..|...
Human   601 SAAFYASYLSRLPAVRCLALFMGTAVLVHLALTLVWLPASAVLHERYLARGCARRARGRWEGSAP 665

  Fly   433 RKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINN 497
            |:.|.::.. |::.:..|.......|::.::..|:                :.|
Human   666 RRLLLALHR-RLRGLRRAAAGTSRLLFQRLLPCGV----------------IKF----------- 702

  Fly   498 KWCKAIIILAFASYLVGACYGITQIKEGLERRKLSR------EDSYSVEFFDREDDYYRE---FP 553
               :.|.|..||:...|..| |..:...|....|..      ..|:..|.||.|   ||:   |.
Human   703 ---RYIWICWFAALAAGGAY-IAGVSPRLRLPTLPPPGGQVFRPSHPFERFDAE---YRQLFLFE 760

  Fly   554 YRMQ--------VIIAG--PLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERN 608
            ...|        |::.|  |::..|||   ...:.:|.:...::..|....:.||.: |....||
Human   761 QLPQGEGGHMPVVLVWGVLPVDTGDPL---DPRSNSSLVRDPAFSASGPEAQRWLLA-LCHRARN 821

  Fly   609 NELLNVTVDDEQTFIDAVKEHWL------------------------------FPGNP-FSLD-- 640
                       |:|.|.::|.|.                              ||..| |.|.
Human   822 -----------QSFFDTLQEGWPTLCFVETLQRWMESPSCARLGPDLCCGHSDFPWAPQFFLHCL 875

  Fly   641 ----VRFNEDETQIIASRF-----LIQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFF 696
                :....|.||.:..||     |...|....||..                |:..::...:|:
Human   876 KMMALEQGPDGTQDLGLRFDAHGSLAALVLQFQTNFR----------------NSPDYNQTQLFY 924

  Fly   697 DQ---------------------------FELVRPVSLQ-AMVIGAIIMMIISFVFIP--NILCS 731
            ::                           :.|...:|.: |:|:|..:.:..:.:.:.  |:..|
Human   925 NEVSHWLAAELGMAPPGLRRGWFTSRLELYSLQHSLSTEPAVVLGLALALAFATLLLGTWNVPLS 989

  Fly   732 LWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVRE 796
            |:...:|....|...|.:.|.:..|::...:.|...:|.|||||.:.|.:|.........:||..
Human   990 LFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSVDFTVNYCISYHLCPHPDRLSRVAF 1054

  Fly   797 ALHSLGLPIIQGSSSTILGIVALLLA-------------QSYIFLVFFKMV---FLVIFFGAMHG 845
            :|.       |.|.:|.:|..||..|             :..|.|:..|.|   |...||.:
Human  1055 SLR-------QTSCATAVGAAALFAAGVLMLPATVLLYRKLGIILMMVKCVSCGFASFFFQS--- 1109

  Fly   846 LFLLPVLLSLFGP-GSC---------LTWTGKDDGSDAEVDDGLDDRQLEKPFSQSYYMQYPSIG 900
                  |...||| .:|         |.|           |.|..|...||            .|
Human  1110 ------LCCFFGPEKNCGQILWPCAHLPW-----------DAGTGDPGGEK------------AG 1145

  Fly   901 INGPYGSKGFLGAPYKAYGVDEKDLGLGTSGEDSSESSSSRSQHRQQAAATEEEVVVRESP--TR 963
            ...|....|..|:..:.|.:..    |......|.::|::.|:...:.:...|::.:.:.|  :|
Human  1146 RPRPGSVGGMPGSCSEQYELQP----LARRRSPSFDTSTATSKLSHRPSVLSEDLQLHDGPCCSR 1206

  Fly   964 RYDDGWRRSSYQNIYGQGAAQFQAQPDLYGKQVSATEWRQRLDTHE---QQQRQRQRRSPFENYR 1025
                              .....|.|            |:.|..|:   .|....|..||   |:
Human  1207 ------------------PPPAPASP------------RELLLDHQAVFSQCPALQTSSP---YK 1238

  Fly  1026 QDVEIDMQKARRNSHGDVID-LHGTPNSSVEERFRRRGEP-----FSAESGDDSSYRHQQIMAMP 1084
            |.......:||::|.|:..: |..:|.:.......:..:|     .||.:.:..|...:..::.
Human  1239 QAGPSPKTRARQDSQGEEAEPLPASPEAPAHSPKAKAADPPDGFCSSASTLEGLSVSDETCLST- 1302

  Fly  1085 AAGSAPSAK 1093
               |.|||:
Human  1303 ---SEPSAR 1308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	161/843 (19%)
		Sterol-sensing	295..442	CDD:289145	37/167 (22%)
DISP2	NP_277045.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..91
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..138
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..264
		MMPL	<580..646	CDD:304422	13/65 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1169..1192		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1229..1337		19/87 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1352..1401

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154908
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840