DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptr and Ptchd3

DIOPT Version :9

Sequence 1:NP_001246145.1 Gene:Ptr / 35546 FlyBaseID:FBgn0262867 Length:1169 Species:Drosophila melanogaster
Sequence 2:NP_083325.1 Gene:Ptchd3 / 74675 MGIID:1921925 Length:906 Species:Mus musculus


Alignment Length:883 Identity:281/883 - (31%)
Similarity:483/883 - (54%) Gaps:76/883 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 CGISCVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQL---KYQIDPEYLFSPIAGE 64
            |..:|::..|::.|...|..:..:|..|::.|.|||....||...|   |..::.:|  :||...
Mouse    71 CHTNCLEAPLSRGFQRFGATVGANPWLFLLGPALLTASLGTGLIFLPKEKENLEEQY--TPIGSP 133

  Fly    65 GKTERAIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNAT 129
            .|.||..|:.:|..|.|:||:..|.:....|..::|::.  ..:::..|:|:|:.:||..:|...
Mouse   134 AKAERRFVQGHFSTNDTYRFSASRTSSETNFASILVVSL--ANSLLEPEIFKEVSKLDQAVQALK 196

  Fly   130 TTYD-GDTYTYKDNCARWENECF----------ENDILNLDALMDDIEAGQLNLTFPFMFNPVTW 183
            ...: |....|::.||:::..|.          .|..|||.           :|||| :.|..|.
Mouse   197 VVQENGTQILYQEVCAKYKTLCVPPNPLLFSWQHNSSLNLS-----------DLTFP-IHNTPTQ 249

  Fly   184 DAHLFPVFFGGTKLTE----DNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSG 244
            ..:| ..||||..|.:    ...::...|::|:|::..:......:...|...||....:.::|.
Mouse   250 LIYL-AGFFGGNVLGQMTGKSQRLVESRAMRLLYYLKTEDPEDSERSQAWLTHFLDHFNDMKSSL 313

  Fly   245 QFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSA 309
            ..:.|.|.||:|.:...|.|..:|||:|.|...::|:.||::::|...|.:|:|..:.:.|..|.
Mouse   314 TLEEIEVVYFSSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRLDCIRNKMCVAVFGVFSV 378

  Fly   310 IMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAA 374
            .|:.::.|||.::.|:.|:.|...:|||::|:|:||.|:|::.|::|.....:.||:....|:.|
Mouse   379 AMSVVSGFGLMLHLGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLSESIRERLSNSYSKVA 443

  Fly   375 VSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSI 439
            ||||||::|:.::|..||.|.||||:.||.|:...:.|.:.:.||.|.|.||:.|.||       
Mouse   444 VSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAVMALDGKRE------- 501

  Fly   440 FGCRVQPMSVAIK---EKRNFLYKAI-------MAGGIDANDPDNPIDNKDHMLMAFFKDKMAAV 494
                     ||..   ||.:..|.::       ....||.:..||      |.:..||:|.....
Mouse   502 ---------VAWSRWLEKPDQKYSSLKKSCCVPFGSLIDKHGEDN------HPMNLFFRDYFGPF 551

  Fly   495 INNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVI 559
            :.....|.|::|.:..|::.:.||..|::|||:.|.|:.:|||...:|:.|:||:.::..|:.||
Mouse   552 LTTSKAKFIVVLLYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVI 616

  Fly   560 IAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFID 624
            :...:||.|..|:::::...:..|...|| .:..||.||.:::.::..:....|    |:.||::
Mouse   617 VTESVNYWDNDVRQKLDKCMTQFEENEYV-DKNLTEFWLEAYMQYMNSSGNNPN----DKNTFMN 676

  Fly   625 AVKEH-WLFPGNPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSPLNASI 688
            .:... ..||  .|:.|:..: ...:|.:||..||.|:::.::::|.|:..||.|.::..:...:
Mouse   677 NIAGFLQFFP--IFTYDINIS-SSNEITSSRGFIQIVDVSSSSNKKRMLLKLRSIAENCEVPLMV 738

  Fly   689 FHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWD 753
            ::..|::|||:..:...:::.::|.:..|.|:|.:.||:.:|||||.|::.|:.:||.|:||.|:
Mouse   739 YNQAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWN 803

  Fly   754 VNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVA 818
            |||||||||||::|||||.||:|||.|.::||.:.|...:..|||:.||.|::|.:.|||:|:..
Mouse   804 VNLDSISMINLVICIGFSFDFSAHISYAFVSSTEPSVNKKSIEALYLLGYPVLQSAISTIIGVCV 868

  Fly   819 LLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLF 856
            |..|::|||..|||::|||:||||.|||..:||.|:.|
Mouse   869 LSAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF 906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtrNP_001246145.1 Patched 53..845 CDD:280598 259/817 (32%)
Sterol-sensing 295..442 CDD:289145 54/146 (37%)
Ptchd3NP_083325.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70
Patched 127..906 CDD:280598 265/825 (32%)
MMPL 363..503 CDD:304422 54/155 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845388
Domainoid 1 1.000 448 1.000 Domainoid score I522
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H111041
Inparanoid 1 1.050 483 1.000 Inparanoid score I1432
Isobase 1 0.950 - 0 Normalized mean entropy S5641
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001635
OrthoInspector 1 1.000 - - oto92378
orthoMCL 1 0.900 - - OOG6_102973
Panther 1 1.100 - - LDO PTHR10796
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3619
SonicParanoid 1 1.000 - - X653
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1413.870

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