DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and Ptchd3

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_003751038.1	Gene:	Ptchd3 / 688333	RGDID:	1590039	Length:	905	Species:	Rattus norvegicus

Alignment Length:	878	Identity:	280/878 - (31%)
Similarity:	482/878 - (54%)	Gaps:	65/878 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CGISCVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQL---KYQIDPEYLFSPIAGE 64
            |...|::..|:..|..||..:..:|..|::.|||||....||...|   |..::.:|  :||...
  Rat    69 CHTDCLEAPLSSCFLRLGALVGANPWLFLLGPVLLTASLGTGLIFLPKEKENLEEQY--TPIGSP 131

  Fly    65 GKTERAIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNAT 129
            .|.||..|:.:|..|.::||:..|.:....|..::|::.  .::::..|.|.|:.:||..:|...
  Rat   132 AKAERRFVQSHFSTNDSYRFSASRTSSETNFASILVVSH--RDSLLEPEAFAEVSRLDRAVQALK 194

  Fly   130 TTYD-GDTYTYKDNCARWENECF----------ENDILNLDALMDDIEAGQLNLTFPFMFNPVTW 183
            ...: |....|.:.||::...|.          :|..|||.           .||||  .:.|.
  Rat   195 VVQENGTQILYPEVCAKYSVGCVPPNPLLFSWQQNSSLNLS-----------ELTFP--IHSVA- 245

  Fly   184 DAHLFPV--FFGGTKL---TEDN--YVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAE 241
             .||..:  ||||..|   |..|  .::...|::|:|::..:......:...|...||....:.:
  Rat   246 -DHLIHLAGFFGGNVLGYATTGNRQRLVESRAMRLLYYLKTEDPEDRERSQAWLTHFLDHFNDMK 309

  Fly   242 NSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGN 306
            :....:.|.|.||.|.:...|.|..:|||:|.|...::|:.||::::|...|.:|:|.::.:.|.
  Rat   310 SDLALEDIEVVYFTSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRLDCIRNKMWVAVFGV 374

  Fly   307 VSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMS 371
            .|..|:.::.|||.::.|:.|:.|...:|||::|:|:||.|:|::.|::|.....|:||:....|
  Rat   375 FSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLTESVSERLSNSYS 439

  Fly   372 EAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNL 436
            :.|||||||::|:.::|..||.|.||||:.||.|:...:.|.:.:.||.|.|.||:.|.||
  Rat   440 KVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKRE---- 500

  Fly   437 HSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCK 501
             .::...::.........:.|.  .:..|..    ||...|: :|.:..||:|.....:.....|
  Rat   501 -VVWSRWLEKPDQKYSSFKKFC--CVPFGSF----PDEHGDD-NHPMNLFFRDYFGPFLTTSKAK 557

  Fly   502 AIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNY 566
            .|::|.:..|::.:.||..|::|||:.|.|:.:|||...:|:.|:||:.::..|:.||:...:||
  Rat   558 FIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVIVTETVNY 622

  Fly   567 SDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLER--NNELLNVTVDDEQTFIDAVKEH 629
            .|..|:::::...:..|...|| .:..||.||.:::.::..  ||.      :|:.||::.:...
  Rat   623 WDKDVRQKLDKCMTQFEQNEYV-DKNLTEFWLEAYMQYMNNTGNNP------NDKNTFMNNIAGF 680

  Fly   630 W-LFPGNPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYF 693
            . .||  .|:.|:..: ...:|.:||..||.::::.::::|.|:..||.|.::..:...:::..|
  Rat   681 LNFFP--VFTYDINVS-SSNEITSSRGFIQTIDVSSSSNKKRMLLKLRGIAENCEVPLMVYNQAF 742

  Fly   694 VFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDS 758
            ::|||:..:...:::.::|.:..|.|:|.:.||:.:|||||.|::.|:.:||.|:||.|:|||||
  Rat   743 IYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDS 807

  Fly   759 ISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQ 823
            ||||||::|||||.||:|||.|.::||.:.|...:..|||:.||.|::|.:.|||:|:..|..|:
  Rat   808 ISMINLVICIGFSFDFSAHISYAFVSSNEPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAK 872

  Fly   824 SYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLF 856
            :|||..|||::|||:||||.|||..:||.|:.|
  Rat   873 AYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	256/812 (32%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	55/146 (38%)
Ptchd3	XP_003751038.1	Patched	125..905	CDD:280598	262/820 (32%)
Ptchd3	XP_003751038.1	MMPL	362..500	CDD:304422	53/137 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348798
Domainoid	1	1.000	446	1.000	Domainoid score	I507
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111041
Inparanoid	1	1.050	479	1.000	Inparanoid score	I1415
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	1	1.000	-	-		FOG0001635
OrthoInspector	1	1.000	-	-		oto95946
orthoMCL	1	0.900	-	-		OOG6_102973
Panther	1	1.100	-	-	LDO	PTHR10796
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.900