DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and Ptchd4

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001342199.1	Gene:	Ptchd4 / 627626	MGIID:	1920485	Length:	904	Species:	Mus musculus

Alignment Length:	887	Identity:	231/887 - (26%)
Similarity:	420/887 - (47%)	Gaps:	86/887 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KSFYH-LGICIAKHPGYFIIIPVLLTL-LCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYF 76
            :||.| ||:|:::||.:|:.:|.:||: ..::...:.:.:.|.|.|.:|.....|.||::....|
Mouse    28 QSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQTEGDLERLVAPSHSLAKIERSLASSLF 92

  Fly    77 KVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDGDTYTYKD 141
            .::.:.......:..|||:||||:::..||..:::.|   .:.|....:......:.|..||:..
Mouse    93 PLDQSKSQLYSDLHTPGRYGRVILLSSPGDNILLQAE---GILQTHRAVMEMKVNHKGYNYTFSH 154

  Fly   142 NCA--RWENECFENDILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVFFGGTKL------- 197
            .|.  ..:.:|..:||:   ::::|:....::       |..|....   |.:..|||
Mouse   155 LCVLRNQDKKCVLDDII---SVLEDLRQAAVS-------NKTTARVQ---VRYPNTKLKDGRNSF 206

  Fly   198 -------------TEDNYVISVPAIQLVYFV-TADTKRQDAKGAEWEETFLRVVGNAENSGQFKH 248
                         ::|..|.|..|||:.|:: |..:..||..|.:||..|.:::...:...|  .
Mouse   207 IGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCKLMRKLQEEHQ--D 269

  Fly   249 ISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIIT-----CMMGDAVRSKPFLGLMGNVS 308
            :.:...||.:|..:..|.:     ..:.:.:|:.|..|:|     ..|.|.:||||||||:|.::
Mouse   270 LQLYSLASFSLWRDFHKTS-----ILTRSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLT 329

  Fly   309 AIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEA 373
            ..::...|.|:......::....|..||..:|.|....|.:|:||||||..:|..:|:....|:.
Mouse   330 VCISIATAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTKENLPFKDRVADAYSDV 394

  Fly   374 AVSITITSVTDFISFLIGIISPF---RSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKN 435
            .|:.|:||...||:|.:| .|||   .:|:|||.....::...:.:..:||.:|:..:|..|:..
Mouse   395 MVTYTMTSSLYFITFGMG-ASPFTNIEAVKIFCQNMCVSILLNYFYIFSFFGSCLVFAGQLEQNR 458

  Fly   436 LHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGID--ANDPDNPIDNKDHMLMAFFKDKMAAVINNK 498
            .||||.|::.  |....:::...::.:|:.|..  ::...||..:  |.:..|.::.....|.|.
Mouse   459 YHSIFCCKIP--SAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQH--HFIQHFLREHYNEWITNI 519

  Fly   499 WCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGP 563
            :.|..:::.:..|...:..|..||.:|.....|...||.||.:...:..|:..:...:...:..|
Mouse   520 YVKPFVVILYLIYASFSFMGCLQISDGASIINLLASDSPSVSYAMVQQKYFSNYSPVIGFYVYEP 584

  Fly   564 LNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKE 628
            |.|.:..|||.::.|.|...          ..||:..:..||:.:    |::.:::..||..::.
Mouse   585 LEYWNSSVQEDLQRLCSGFT----------AVSWVEQYYQFLKTS----NISANNKTDFISVLQS 635

  Fly   629 HWLFPGNP----FSLDVRFNE--DETQIIASRFLIQAVNITDTNHEK-EMVRDLRQICKDSPLNA 686
            .:|  ..|    |..|:.|:.  ||..|||||..:.|....|...|. |::..||.:.....:..
Mouse   636 SFL--KKPEFQHFRNDIIFSRAGDENNIIASRLYLVARTSRDKQKEVIEVLDKLRPLSLSKSIRF 698

  Fly   687 SIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMAL 751
            .:|:|.|||.|.:.|...|.:.....|.::::|::|..:.:.|.:.|:..||.||||||.|.|.|
Mouse   699 IVFNPSFVFTDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLGLMTL 763

  Fly   752 WDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGI 816
            |:|::|.||::.||..:.|::|..|.:.||::.:.:.:....::.:|...|..|:|..:|.::|:
Mouse   764 WNVDMDCISILCLIYTLNFAIDHCAPLLYTFVLATEHTRTQCIKSSLQEHGTAILQNITSFLIGL 828

  Fly   817 VALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGP 858
            :.||...|.:....||.:.|......:|...:|||.|:.|.|
Mouse   829 LPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPP 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	212/831 (26%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	51/149 (34%)
Ptchd4	NP_001342199.1	Patched	84..870	CDD:355433	213/829 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845396
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810