DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptr and PTCH1

DIOPT Version :9

Sequence 1:NP_001246145.1 Gene:Ptr / 35546 FlyBaseID:FBgn0262867 Length:1169 Species:Drosophila melanogaster
Sequence 2:NP_000255.2 Gene:PTCH1 / 5727 HGNCID:9585 Length:1447 Species:Homo sapiens


Alignment Length:1471 Identity:282/1471 - (19%)
Similarity:494/1471 - (33%) Gaps:480/1471 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 YHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYFKVNYT 81
            :.||..|.|:.|.|:::.:|:......|.:....:.:.|.|:..:.|....|         :|||
Human    88 FKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRE---------LNYT 143

  Fly    82 HRFNVGR---------ITRPGRFGRVIVITK------DGDENMIRREVFQELRQ----------- 120
             |..:|.         |..|...|..::.|:      |......|..|:...||           
Human   144 -RQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSG 207

  Fly   121 --------LDNIIQ---------------NATTTYDGDTYTYKDNCARWEN----ECFEN----- 153
                    :|.||:               .......|..|.......||.|    |..|.     
Human   208 ELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKIN 272

  Fly   154 -DILNLDALMDDIEAGQLNLTFPFMFNP-----------------------------------VT 182
             .:.:.:.:::..|.|...:..|.: ||                                   :.
Human   273 YQVDSWEEMLNKAEVGHGYMDRPCL-NPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMH 336

  Fly   183 WDAHLFPVFFGGTKLTEDNYVISVPAIQLVY-FVTADTKRQDAKGAE------------------ 228
            |...|   ..|||.......::|..|:|.:: .:|.....:..||.|                  
Human   337 WQEEL---IVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEA 398

  Fly   229 WEETFLRVVGN--AENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMM 291
            |:.|::.||..  |:||.|    .|..|.:.|||..|:..:...|...:|.:|||..::.:|.:.
Human   399 WQRTYVEVVHQSVAQNSTQ----KVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLR 459

  Fly   292 GDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAA----PFLMIGIGIDDTFVMLAG 352
            .|..:|:..:||.|.:...::..|..||....||.|   |.|.    |||.:|:|:||.|::...
Human   460 WDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISF---NAATTQVLPFLALGVGVDDVFLLAHA 521

  Fly   353 WRRT--KAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFL 415
            :..|  ..::|..:|.|..:.....|:.:||:::..:|.:..:.|..::|.|...:...|.|.|.
Human   522 FSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFA 586

  Fly   416 WHITFFAACMAISGYRERKNLHSIFGCRVQP-MSVAIK---------------------EKRNFL 458
            ..:..|.|.:::..||.......||.|...| :|..|:                     ...:|.
Human   587 MVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFA 651

  Fly   459 YK-------------------------------------AIMAGGIDANDPDNPIDNKDHMLMAF 486
            ::                                     .:....:....|::....:|  |::.
Human   652 HETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRD--LLSQ 714

  Fly   487 FKDKMAAVIN---NKW------------------CKAIIILAFASYLVGACYGITQIKEGLERRK 530
            |.|.....:.   .||                  .|.::|..|...|..:.||.|::::||:...
Human   715 FSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTD 779

  Fly   531 LSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYV---TSRR 592
            :...::...:|...:   ::.|.:....|:....:|  |.:|..:.:|..:..:..||   .:::
Human   780 IVPRETREYDFIAAQ---FKYFSFYNMYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQ 839

  Fly   593 YTESWLRSFLSFLE----------------RNN----------------------ELLNVTVDDE 619
            ..:.||..|..:|:                .||                      :.::::...:
Human   840 LPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTK 904

  Fly   620 QTFIDA------------------------------VKEH---WLFPGNPFSLDVRFNEDETQII 651
            |..:||                              ::.|   |:.....:..:.|......:.|
Human   905 QRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPI 969

  Fly   652 A-SRFLIQAVNITDTNHEKEMVRDLRQICKD-SPLNASIF---HPYFVFFDQFELVRPVSLQAMV 711
            . ::|......:.||:...|.:..:|.||.: :.|..|.:   :| |:|::|:     :.|:..:
Human   970 EYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYP-FLFWEQY-----IGLRHWL 1028

  Fly   712 IGAI-IMMIISFVFIPNILCSLWVA------FSVISIELGVAGYMALWDVNLDSISMINLIMCIG 769
            :..| :::..:|:.....|.:.|.|      .:::::||  .|.|.|..:.|.::.::.||..:|
Human  1029 LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL--FGMMGLIGIKLSAVPVVILIASVG 1091

  Fly   770 FSVDFTAHICYTYMSS---KKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQS---YIFL 828
            ..|:||.|:...::::   |.|    |...||..:..|::.|:.||:||:  |:||.|   :|..
Human  1092 IGVEFTVHVALAFLTAIGDKNR----RAVLALEHMFAPVLDGAVSTLLGV--LMLAGSEFDFIVR 1150

  Fly   829 VFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCLTWTGKDDGSDAEVDDGLDDRQLEKPFSQSYY 893
            .||.::.::...|.::||.|||||||.|||                                   
Human  1151 YFFAVLAILTILGVLNGLVLLPVLLSFFGP----------------------------------- 1180

  Fly   894 MQYPSI----GIN--------GPYGSKGFLGAPYKAYGVDEKDLGLGTSGEDSSESSSSRSQHRQ 946
              ||.:    |:|        .|.....|...|           |...||.|||:|..|   .:.
Human  1181 --YPEVSPANGLNRLPTPSPEPPPSVVRFAMPP-----------GHTHSGSDSSDSEYS---SQT 1229

  Fly   947 QAAATEEEVVVRESPTRRYDDGWRRSSYQNIYGQGAAQFQAQPDLYGKQVSATEWRQRLDTHEQQ 1011
            ..:...||:       |.|:                ||..|....:...|.|||  ..:..|...
Human  1230 TVSGLSEEL-------RHYE----------------AQQGAGGPAHQVIVEATE--NPVFAHSTV 1269

  Fly  1012 QRQRQRRSPFENYRQDVEIDMQKARRNSHGDVIDLHGTPNSSVEERFRRRGEPFSAESGDDSSYR 1076
            .....|..|..|.||...:|.........|.                :.|.:|            
Human  1270 VHPESRHHPPSNPRQQPHLDSGSLPPGRQGQ----------------QPRRDP------------ 1306

  Fly  1077 HQQIMAMPAAGSAPSAKRYHRRRSSEDSTSRHQ------RW-PANIEERRARRAYS-------PA 1127
                   |..|..|...| .||.:.|.||..|.      || |........|...|       |.
Human  1307 -------PREGLWPPPYR-PRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPG 1363

  Fly  1128 HNRPETALTSYAYRSSSHHNLYQPN-GKSSK------YPPT 1161
            :.:|.|.:|:.|..:.:.|....|. |::.:      ||.|
Human  1364 YCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPET 1404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtrNP_001246145.1 Patched 53..845 CDD:280598 200/1084 (18%)
Sterol-sensing 295..442 CDD:289145 40/152 (26%)
PTCH1NP_000255.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
2A060602 43..1206 CDD:273338 225/1196 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1189..1234 13/58 (22%)
PHA03377 <1253..1369 CDD:177614 31/153 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1270..1360 24/125 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154930
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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