DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and si:ch211-250m6.7

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_021327233.1	Gene:	si:ch211-250m6.7 / 565624	ZFINID:	ZDB-GENE-041210-239	Length:	868	Species:	Danio rerio

Alignment Length:	898	Identity:	320/898 - (35%)
Similarity:	508/898 - (56%)	Gaps:	75/898 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTCGISCVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQ--IDPEYLFSPIAG 63
            |.|...|:::.|:..|..||..|.:||..||::.:.:......|:..||.:  .|.|..|:|:.|
Zfish     1 MKCKTDCIERPLSLVFEKLGRLIGRHPVVFILLSLYVAAGLGAGFIFLKEREANDIEDQFTPVNG 65

  Fly    64 EGKTERAIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNA 128
            ..|.:|.||.::|..  :..|:..|:...|.:..:|:....| ||::....|:|:..||.  |..
Zfish    66 PAKRDREIVAEHFPP--SDEFSQLRLMSEGTYASLIITDLQG-ENILTAAAFEEILALDR--QVK 125

  Fly   129 TTTYDGDTYTYKDNCARWENECFEN---DILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPV 190
            |..:.|:  |::..||:.:..|..|   ||:..:|.  ||::  :.:|:|..      |......
Zfish   126 TLQHLGN--TFEKLCAKIKGNCVSNAVLDIIRYNAA--DIDS--VTITYPIN------DKTFLGT 178

  Fly   191 FFGGTKLTEDNYVI-SVPAIQLVYFVTADTKRQDAKG-AEWEETFLRVVGNAENSGQFKHISVSY 253
            ..||.:...::.:: |..||:|.||:  |.|:  :|| |:|.|.|::...|..:.   :.:||||
Zfish   179 TIGGVETQPNSSMLKSAKAIRLYYFL--DEKK--SKGNADWLEGFIQFFSNYTDQ---EKVSVSY 236

  Fly   254 FASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFG 318
            |.|.:..:|.|.||.:|:|.||.|:.|....::::|:..|.||:|.::.|:|.|||.||.||:||
Zfish   237 FTSVSRQNEFEGNTDSVIPLFSITYALAINIAVLSCLRLDCVRTKVWVALLGVVSAGMAVLASFG 301

  Fly   319 LAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVT 383
            |.::||:.|.....:||||::|:|:||.|:|::.|::|.....|..|:.....||.||||||::|
Zfish   302 LLLFCGMPFAMTVGSAPFLILGVGVDDMFIMISSWQKTAVDKGVEFRLAEAYKEAGVSITITTLT 366

  Fly   384 DFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRV-QPM 447
            |.::|.||:::|||||:.||.|:..|:.|.:|::||||.||:|::|.||:.|.|.:....| :|.
Zfish   367 DVLAFYIGLLTPFRSVQSFCMYTSTALLFCYLFNITFFGACLALNGRREKSNRHFLTCMTVPKPS 431

  Fly   448 SVAIKEKRNFLYKAIMAGG-IDANDPDNPIDNKDH--MLMAFFKDKMAAVINNKWCKAIIILAFA 509
            ..|:         :..||| .|.|      .||:|  .:..|||......:...|.|.::.|.:|
Zfish   432 GDAV---------SCCAGGAFDEN------TNKEHEMPMEVFFKKYYGPFLAKVWVKVLVCLIYA 481

  Fly   510 SYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREF-PYRMQVIIAGPLNYSDPLVQE 573
            .||..:.||..|::|||:.:.|:.:.||..:::||||:::..| |..|.||......|..|..::
Zfish   482 GYLAVSIYGCFQMEEGLDLKHLATDGSYVADYYDREDEFFSAFGPNVMLVIKDEHFQYWSPDARK 546

  Fly   574 QVENLTSTLEHTSYVTSRRYTESWLRSFLSF----LERNNELLNVTVDDEQTFIDAVKEHWLFPG 634
            .::.........:.|.|.....|||.:::.|    .:.|||::..|  ....|::.
Zfish   547 SLDLCLKNFRDLTMVDSEIPLTSWLDAYMKFGQSSFDLNNEMIFKT--QLPAFLNR--------- 600

  Fly   635 NPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICK-----DSPLNASIFHPYFV 694
            :.||.||.|.::  .|.|:|..||.|||.....||:|:...|:...     ::|::..::||.|:
Zfish   601 SEFSHDVHFTDN--NINATRMFIQTVNIKTAIDEKDMLNAFREAAHTCGRLETPVDLIVYHPAFI 663

  Fly   695 FFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSI 759
            :|||:.::...::|.:|....:|::||.:.||:.||||||.||:.|:.:|:||:|||||::|||:
Zfish   664 YFDQYAVIVSNTIQNLVAATCVMLVISLLLIPHPLCSLWVTFSIASVIVGLAGFMALWDISLDSV 728

  Fly   760 SMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQS 824
            |||||::||||||||:|||.|.::||:|.|...:..:|||.||.|||||:.|||.|:|.|..|:|
Zfish   729 SMINLVICIGFSVDFSAHISYAFVSSEKSSANEKATDALHKLGYPIIQGAVSTIAGVVVLAAAKS 793

  Fly   825 YIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCLTWTGKDDGSDAEVDD 877
            |||..|||::||||.|||:||:..|||.||..  |.|.....||:....:..:
Zfish   794 YIFRTFFKIMFLVILFGALHGIVFLPVFLSFL--GICSNRRVKDEPEQKDTSE 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	294/810 (36%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	68/146 (47%)
si:ch211-250m6.7	XP_021327233.1	Patched	54..823	CDD:330476	299/820 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	492	1.000	Domainoid score	I358
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1255
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	1	1.000	-	-		FOG0001635
OrthoInspector	1	1.000	-	-		otm26181
orthoMCL	1	0.900	-	-		OOG6_102973
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3619
SonicParanoid	1	1.000	-	-		X653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000