DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptr and ptchd4

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001025356.1	Gene:	ptchd4 / 564097	ZFINID:	ZDB-GENE-041001-178	Length:	897	Species:	Danio rerio

Alignment Length:	885	Identity:	237/885 - (26%)
Similarity:	423/885 - (47%)	Gaps:	71/885 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLC-MTGYQQLKYQIDPEYLFSPIAGEGKTERAI 71
            :.:.|..|||.||:.:::||.:|:.:|.:||::. .|...:.|.:.|.|.|.:|.....|.||::
Zfish     6 IHRGLKASFYWLGLFVSRHPVFFLTVPAVLTIIFGSTVLSRFKPETDLEILVAPTHSLAKIERSL 70

  Fly    72 VEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDGDT 136
            ....|.::.:.......:..|||:||:|::.:.|. |::  |:.:::.|:...:.:....|.|..
Zfish    71 ANSLFPIDQSKHKLYSDLHTPGRYGRLILLARSGG-NIL--ELAEQVLQVHKKVLDMRVNYKGFN 132

  Fly   137 YTYKDNCA--RWENECFENDILNLDALMDDIEAGQL-NLTF---PFMF-------NPVTWDAHLF 188
            ||:...|.  ..:..|..:||:   .:.:||....| |.||   |..:       ..|::..|.
Zfish   133 YTFAHLCVLRHRDKRCLLDDII---TIFEDIRLAVLSNSTFSKVPVSYPNTTLKDGRVSFIGHQ- 193

  Fly   189 PVFFGGTKL---TEDNYVISVPAIQLVYFV-TADTKRQDAKGAEWEETFLRVVGNAENSGQFKHI 249
               .||..|   ..|..|....|||:.|:: ......||....:||..|.::|.......|..||
Zfish   194 ---LGGVALPANNRDQQVKFARAIQITYYLRNLGPVVQDIIAEKWETEFCKLVHQLATDSQELHI 255

  Fly   250 -SVSYFASRTLDHE---LEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAI 310
             |::.|:.....|:   |.|:...|      :.:|:.|.:.|:..|.|.:|.||||||:|.::..
Zfish   256 QSLTSFSLWRDFHKTGVLAKSEVLV------SLVLVLLAATISSSMRDCLRGKPFLGLLGVLTIC 314

  Fly   311 MATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAV 375
            :|.:.|.|:......:|....|..||..:|.|....|.:|||||||:..:|..||:....::..|
Zfish   315 IANVTAAGIFFISDGKFNSTLLGIPFFAMGHGTKGVFELLAGWRRTRESLPFKERVADAFADVMV 379

  Fly   376 SITITSVTDFISFLIGIISPF---RSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLH 437
            ..|:||....|:|.:| .|||   .||::||.....||...:.:..:|:.:|:..:|..|:...|
Zfish   380 CYTMTSSLYIITFGMG-ASPFTNIESVKVFCQSMCVAVLVNYFYVFSFYGSCLVFAGQLEQNRYH 443

  Fly   438 SIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKA 502
            |:|.|::.  ||...:::...:|.:|:.|.|.:...:.:..::|.:..|.::.....|.|.:.|.
Zfish   444 SVFCCKIP--SVEYLDRQPTWFKTMMSDGHDLSTHHDSVPYQNHFIQHFLREHYTEWITNTYVKP 506

  Fly   503 IIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYS 567
            .:::.:..|...:..|..||.:|.....|...:|.||.|...:..|:..:...:...|..|:.|.
Zfish   507 FVVILYLIYASFSFMGCLQISDGSNIINLLASNSPSVSFALTQQKYFSNYSPVIGFYIYEPIEYW 571

  Fly   568 DPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKEHWLF 632
            :..|||.::.|.......          ||:.::..||    .::|::...:..||..:|..:|
Zfish   572 NSTVQEHLKTLGQGFNKI----------SWIDNYFHFL----RVVNISASTKSDFISILKTSFL- 621

  Fly   633 PGNP----FSLDVRFNED--ETQIIASRFLIQAVNITDTNHE-KEMVRDLRQICKDSPLNASIFH 690
             .:|    |..|:.|:::  |..||||:..:.|.....|..| .|::..||.:...:.:...:|:
Zfish   622 -RSPEYQHFVDDIIFSKNGAEYDIIASKMYLVARTTEKTREEVVELLERLRPLSLINSIKFIVFN 685

  Fly   691 PYFVFFDQF--ELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWD 753
            |.|||.|::  .::.|:......:  :.::|::|..:.|.|.:.|:..:|.|:||||.|.|.||:
Zfish   686 PTFVFMDRYSSSIISPILTSGFSV--LTILILTFFLVINPLGNFWLILTVTSVELGVLGLMTLWN 748

  Fly   754 VNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVA 818
            |::||||::.||..:.|::|..|...||::.:.:.:....::.:|...|..|:|.:|..::||:.
Zfish   749 VDMDSISILCLIYTLNFAMDHCAPHLYTFVLATEHTRTQCIKISLEEHGAAILQNTSCFVIGIMP 813

  Fly   819 LLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGP 858
            ||...|.:....||...|......:|...:|||.|:.|.|
Zfish   814 LLFVPSNLTYTLFKCSLLTAGCTVLHCFVILPVFLTFFPP 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	216/824 (26%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	51/149 (34%)
ptchd4	NP_001025356.1	Patched	97..853	CDD:280598	209/792 (26%)
		MMPL	298..449	CDD:304422	51/151 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..881
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589961
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850