Protein Alignment Ptr and Npc1l1

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001002025.1
• Gene: Npc1l1 / 432367
• RGDID: 1303135
• Length: 1331
• Species: Rattus norvegicus
• Alignment Length: 1065
• Identity: 232/1065 - (21%)
• Similarity: 428/1065 - (40%)
• Gaps: 238/1065 - (22%)

  Fly    12 LNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYF 76
            |.:.|.:.|..:|..|...:.:..::.:....|...::...||..|:|....:.:.|::..:::|
  Rat   337 LGRFFQNWGTRVASWPLTVLALSFIVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHF 401

  Fly    77 -------KVNYTHR------------------------FNVGRITRPGRFGRVIVITKDGDENMI 110
                   ::..|.|                        |.:..:....|...:.|.:.:.:.|:.
  Rat   402 GPFFRTNQIFVTARNRSSYKYDSLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNIS 466

  Fly   111 RREV-----------------------FQELRQLDNIIQNATTTYDGDT--YTYKDN---CARWE 147
            .:::                       ||..|.|  ::..|..|.:|.|  ..:||:   ||...
  Rat   467 LQDICYAPLNPYNTSLSDCCVNSLLQYFQNNRTL--LMLTANQTLNGQTSLVDWKDHFLYCANAP 529

  Fly   148 NECFENDILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVF----FGGTKLTEDNYVISVPA 208
            ....:...|.|..:.|                   :.|.:||..    :.||..:|...:|.  .
  Rat   530 LTFKDGTSLALSCMAD-------------------YGAPVFPFLAVGGYQGTDYSEAEALII--T 573

  Fly   209 IQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHELEKNTKTVVPY 273
            ..|..:...|.:...||  .|||.||:.:.:.:.:...| ..|::.|.|:|:.|:.:.|...:|.
  Rat   574 FSLNNYPADDPRMAQAK--LWEEAFLKEMESFQRNTSDK-FQVAFSAERSLEDEINRTTIQDLPV 635

  Fly   274 FSSTFLLMGLFSIITCMMGD-------AVRSKPFLGLMGNVSAIMATLAAFGLAMYCGI-EFIGI 330
            |:.:::::.|:  |:..:|.       ||.||..|||.|.:..:.|.|||.|...|.|: ..:.|
  Rat   636 FAVSYIIVFLY--ISLALGSYSRCSRVAVESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVI 698

  Fly   331 NLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAER---MGLMMSEAAVSITITSVTDFISFLIGI 392
            ....|||::.:|.|:.|:.:..::|. .:||..:|   :|..:...|.|:.:.|:::.|.|.:|.
  Rat   699 IQVVPFLVLAVGADNIFIFVLEYQRL-PRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGA 762

  Fly   393 ISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRE---RKNLHSIFGCRVQPMSVAIKEK 454
            ::|..:||.|...|..|:...||..:|.|.|.:::...|:   |.::...|..|..|
  Rat   763 LTPMPAVRTFALTSGLAIILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLP-------- 819

  Fly   455 RNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGI 519
                                |...|:.:|:.||:...|..:.:::.:.:::|.|.:......|.:
  Rat   820 --------------------PPKEKEGLLLRFFRKIYAPFLLHRFIRPVVMLLFLTLFGANLYLM 864

  Fly   520 TQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQE--------QVE 576
            ..|..||::.....:|||.:::|...:.|....|....|..:| .|:|......        :..
  Rat   865 CNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPVYFVTTSG-FNFSSEAGMNATCSSAGCKSF 928

  Fly   577 NLTSTLEHTSYVTSRRY----TESWLRSFLSFLERNNELLNVTV----DDE-----QTFIDAVKE 628
            :||..:::.|....:.|    ..||:..|:.:|..::....:.:    .||     .|..:.:|.
  Rat   929 SLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLTPSSSCCRLYIRGPHKDEFCPSTDTSFNCLKN 993

  Fly   629 ----------------H----WLFPGNP-----------FSLDVRFNEDETQIIASRFLIQAVNI 662
                            |    |.....|           :...|..:.| .|:|||:|:.....:
  Rat   994 CMNRTLGPVRPTAEQFHKYLPWFLNDPPNIRCPKGGLAAYRTSVNLSSD-GQVIASQFMAYHKPL 1057

  Fly   663 TDTNHEKEMVR-----------DLRQICKDSPLNASIFHPYF---VFFDQFELVRPVSLQAMVIG 713
            .::....|.:|           |||::....| |..:| ||.   ||:.|:..|.|..:..:.:.
  Rat  1058 RNSQDFTEALRASRLLAANITADLRKVPGTDP-NFEVF-PYTISNVFYQQYLTVLPEGIFTLALC 1120

  Fly   714 AIIMMIISFVFIPNILCS-LWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAH 777
            .:...::.::.:...:|| :....|:|.|.:...|.||:|.::.:::|:|||:..:|.||:|.:|
  Rat  1121 FVPTFVVCYLLLGLDMCSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSH 1185

  Fly   778 ICYTYMSSKKRSPKARVREALHSLGLPIIQGSSST-ILGIVALLLAQSYIF-LVFFKMVFLVIFF 840
            |..::..|.|.:...|.::|...:|..:..|.:.| ..||:.|..||:.:. :.||::..|:...
  Rat  1186 ITRSFAVSTKPTRLERAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLL 1250

  Fly   841 GAMHGLFLLPVLLSLFGPGSCLTWTGKDDGSDAEVDDGLDDRQLEKPFSQSYYM------QYPS- 898
            |.:|||..|||:||..||          |.:.|.|       |.||..|::...      ||||
  Rat  1251 GLLHGLVFLPVVLSYLGP----------DVNQALV-------QEEKLASEAAVAPEPSCPQYPSP 1298

  Fly   899 --IGINGPYGSKGFLGAPYKAYGVD 921
              ...|..||.     ||..|:|.:
  Rat  1299 ADADANVNYGF-----APELAHGAN 1318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	198/937 (21%)
Npc1l1	NP_001002025.1	2A060601	32..1267	CDD:273337	212/990 (21%)