Protein Alignment Ptr and disp2

DIOPT Version :9

• Sequence 1: NP_001246145.1
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: XP_005158826.1
• Gene: disp2 / 405793
• ZFINID: ZDB-GENE-030915-1
• Length: 1477
• Species: Danio rerio
• Alignment Length: 1153
• Identity: 217/1153 - (18%)
• Similarity: 403/1153 - (34%)
• Gaps: 345/1153 - (29%)

  Fly    33 IPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYFKVNYTHRFNVGRITRPG-RFG 96
            :|..||....||...:|  .:|::       ..::.|.:    .:.|..|.|   ....|| |:.
Zfish   250 VPWQLTEKTTTGKDTIK--SEPQF-------RERSRRML----HRDNAEHNF---FCNAPGERYA 298

  Fly    97 RVIVITKDGDE----------NMIRREVFQELR---QLDNIIQNATTTYDGDTYTYKDNCARWE- 147
            :::.  :.|:.          :|.:.|..| :|   |.|.:.|..:..|  .:....:.|..|.
Zfish   299 QLVF--RSGNSASLWSLKAIYSMCQMEQTQ-IRSGPQFDKLCQVKSEFY--GSMVKNECCPSWSL 358

  Fly   148 ----------NECFENDILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVFFGGTKLTEDNY 202
                      :.||     :|.:.......|.|....|:.        |...:....|:.::...
Zfish   359 GNYLAVLNNISSCF-----SLTSQQVSESLGLLRFCAPYY--------HDGSLIASCTERSKFGR 410

  Fly   203 VISVP-------AIQLVY------FVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYF 254
            ..|||       ..|:::      |:...|........::...||.|    |.|....:|.:.:.
Zfish   411 CASVPHRCKLSSIFQILHYLVDKDFLGPQTVEYKVPSLKYSIVFLPV----EKSDSLMNIYLDHL 471

  Fly   255 ASRTLDHELEKNTKTVV-----------PYF---SSTF-LLMGLFSIITCMMGDAVRSKPFLGLM 304
            ..    |:|..|..|:.           .|:   .|.: :|..|..:||  :|..::|. |:..|
Zfish   472 EG----HKLTYNNTTITGMDLGIKQKLFKYYLARDSIYPVLAALALLIT--IGLYLKSL-FIAAM 529

  Fly   305 GNVSAIMAT-------LAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPV 362
            ..|:.|::.       ..||.|..     |..:||||.|:::|..::.....:..|:...:..|.
Zfish   530 SLVAVILSLSTSYFFYKVAFRLTF-----FPLLNLAAVFVLLGSCLNQALTFVDFWKLQLSHNPP 589

  Fly   363 A---ERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTY----SVFAVCFTFLW---- 416
            |   :||..::.|....|.::.:|..::|..|.||...:||.:..|    |:....|..:|
Zfish   590 AVPEKRMNRVLQEMGYLIIVSGLTSSVTFYSGYISSITAVRCYAVYLGSASLINTLFALVWLPCT 654

  Fly   417 ----------------HITFFAACMAISG----YRERKNLHSIFGCRVQPMSVAIKEKRNFLYKA 461
                            .:.:...|...:|    ...||.....|..:::.:.....:..|.|:..
Zfish   655 LILQERYAVLSSNTVGKVAWKPCCSKNAGGFWETSSRKRCLFTFRQKLRTLGRGFSDTSNLLFLK 719

  Fly   462 IMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGL 526
            |:..|:                :.|              :.|.|..||....|..| |:.:..|:
Zfish   720 ILPCGV----------------VKF--------------RYIWICWFAVLAAGGTY-ISCVDPGM 753

  Fly   527 ERRKLSREDSYSVEF------FDREDDYYR-EFPYR----------MQVIIAGPL-----NYSDP 569
               ||...||.:.:.      |:|.|..|| :|.:.          |..:|.|.:     ::.||
Zfish   754 ---KLPTSDSRTTQLFRSSHPFERYDAEYRHQFMFERMKDGEDEPMMLTLIWGIVPSDNGDHFDP 815

  Fly   570 LVQEQVENLTSTLEHTSYVTSRRYTESWLR---------SFLSFLERNNELLNVTVDDEQTFIDA 625
                  ::..|......:..|....:.|||         :|.|.|....:    |.:|...|::.
Zfish   816 ------KSNGSLSVDPGFNMSSLQAQIWLRDLCGKIQNQTFYSPLSAEQD----TAEDNVCFVEH 870

  Fly   626 VKEHWL--------------------FPGNPFSLD---------------------VRFNEDETQ 649
            : .||:                    ||..|...:                     :|| :.|.:
Zfish   871 L-IHWVSIRRCSESEDAFSFCCNNIPFPYPPRVFEQCLSMMVAEQHAEGRLPSAGGLRF-DSEGR 933

  Fly   650 IIASRFLIQAVNITDTNHEK--EMVRDL-----RQICKDSPLNASIFHPYFVF-FDQFELVRPVS 706
            |.|...:.:.|.:...|:.:  :..:::     |:|.| :|  |.:...:||. ...::|.:.:|
Zfish   934 IAALVVIFKTVQLYSFNYNRMSQFYQEILSWFNREISK-AP--AGLQRGWFVSQLGLYDLQQCLS 995

  Fly   707 LQAM-VIGAIIMMIISFVFIP--NILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCI 768
            .:.: |.|..:.:..:.:.:.  ||..|::|:.:|........|.:.|.:..|:.:..:.:....
Zfish   996 SETLEVAGFSVALTFALLLLTTWNIPLSVYVSIAVAGSVFATVGLLVLLEWQLNGVEALFISAAA 1060

  Fly   769 GFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTI-LGIV-----ALLLAQSYIF 827
            |.||||.|:.|.:|..:.......||..::..:|.|:..|:.:.. :||:     |||..:..||
Zfish  1061 GLSVDFVANYCISYSLAPHSDRLGRVAHSIKRMGCPVATGAGAYFCVGIIMLPATALLFRKLGIF 1125

  Fly   828 LVFFKMV---FLVIFFGAMHGLFLLPVLLSLFGPGS--------CLTWTGKDD--GSDAEVDDGL 879
            |:..|.|   |...||.:         |...|||.:        |:|....::  .|.:..:.|.
Zfish  1126 LLLVKCVACGFATFFFQS---------LCCFFGPQNNCGRITLPCVTQQSTENILSSCSATEPGT 1181

  Fly   880 DDRQLEKPFSQSYYMQYPSIGINGPYG--------------SKGFLGAPYKAYGVDEKDLG---- 926
            ::               |:  .||.:|              ::||| .|.:.:....:.:|
Zfish  1182 NN---------------PA--ANGAFGCGKGSRVRRSFNKENEGFL-CPNQQHHRKRQPVGGREP 1228

  Fly   927 -------LGTSGEDSSESSSSRSQHRQQAAATEEEV-VVRESPTRRYD 966
                   |.....||.|:|:..|:...:.:...::: ....||.:.||
Zfish  1229 EQNELQPLACQLSDSFENSTCTSKLSNRPSVLSDDIQFCGLSPKQDYD 1276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	184/974 (19%)
		Sterol-sensing	295..442	CDD:289145	38/184 (21%)
disp2	XP_005158826.1	MMPL	517..660	CDD:304422	34/148 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840