DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptr and PTCHD3

DIOPT Version :9

Sequence 1:NP_001246145.1 Gene:Ptr / 35546 FlyBaseID:FBgn0262867 Length:1169 Species:Drosophila melanogaster
Sequence 2:NP_001382672.1 Gene:PTCHD3 / 374308 HGNCID:24776 Length:954 Species:Homo sapiens


Alignment Length:876 Identity:275/876 - (31%)
Similarity:477/876 - (54%) Gaps:59/876 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 CGISCVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQL--KYQIDPEYLFSPIAGEG 65
            |...|::..|:::|..||..:..||..|::.|::||....||:..|  ..:.|.|..::|:....
Human   114 CHTDCLEGLLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPA 178

  Fly    66 KTERAIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATT 130
            |.||..|:.:|..|.::||:..|.:....|..::|::.  .::::....|.|:.:||..:|:...
Human   179 KAERRFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSY--SDSLLDPATFAEVSKLDGAVQDLRV 241

  Fly   131 TYD-GDTYTYKDNCARWENECFE----------NDILNLDALMDDIEAGQLNLTFPFMFNPVTWD 184
            ..: |....|:..|||:...|..          |..|||.           :::|| .:|.....
Human   242 AREKGSQIQYQQVCARYRALCVPPNPILYAWQVNKTLNLS-----------SISFP-AYNHGRHP 294

  Fly   185 AHLFPVFFG---GTKLTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQF 246
            .:|...|.|   |..|.....::...|::|:|::..:....|.:..:|....|....|.:|....
Human   295 LYLTGFFGGYILGGSLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILAL 359

  Fly   247 KHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIM 311
            |.|.|.:|.|.:...|.|..:.||:|.|...::|:.||::.:|...|.:|:|..:...|.:||.:
Human   360 KKIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVISAFL 424

  Fly   312 ATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVS 376
            |.::.|||.::.|:.|:.|...:|||::|:|:||.|:|::.|.:|.....:.|||..:.|:||||
Human   425 AVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVS 489

  Fly   377 ITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFG 441
            ||||::|:.::...||:|.||||:.||.|:...:.|.:.::||.|.|.||:.|.||...|     
Human   490 ITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKREVVCL----- 549

  Fly   442 C---RVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKD-HMLMAFFKDKMAAVINNKWCKA 502
            |   :..|...:.|:...|.:.::         ||.  ...| |.:..||:|.....:.....|.
Human   550 CWLKKADPKWPSFKKFCCFPFGSV---------PDE--HGTDIHPISLFFRDYFGPFLTRSESKY 603

  Fly   503 IIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYS 567
            .::..:..|::.:.||...::|||:.|.|:.:|||...:|:.|::|:.::..|:.||:...::|.
Human   604 FVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVIVTKKVDYW 668

  Fly   568 DPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKEHWL- 631
            |..|::::||.|...|...|| .:..||.||.:::.:|:.|::..|    ::.||::.:.:... 
Human   669 DKDVRQKLENCTKIFEKNVYV-DKNLTEFWLDAYVQYLKGNSQDPN----EKNTFMNNIPDFLSN 728

  Fly   632 FPGNPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFF 696
            ||.  |..|:..: ...:||:||..||..:::.:..:|.::..||:|.:|..:...:::..|::|
Human   729 FPN--FQHDINIS-SSNEIISSRGFIQTTDVSSSAKKKILLFQLRRIAEDCQIPLMVYNQAFIYF 790

  Fly   697 DQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISM 761
            ||:..:...:::.:::.:..|.|:|.:.||..||||||.|::.|:.:||.|:||.|.||||||||
Human   791 DQYAAILEDTVRNVLVASAAMFIVSLLLIPYPLCSLWVTFAIGSVIVGVTGFMAFWKVNLDSISM 855

  Fly   762 INLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYI 826
            |||::|||||.||:.||.|.::||.:.|...:..|||:.||.|::|.:.|||:|:..|..|::||
Human   856 INLVICIGFSFDFSVHISYAFVSSSQPSVNQKSVEALYLLGYPVLQSAISTIIGVCVLAAAKAYI 920

  Fly   827 FLVFFKMVFLVIFFGAMHGLFLLPVLLSLFG 857
            |..|||::|||:.|||.|||..:||.|:.||
Human   921 FRTFFKIMFLVMIFGAAHGLIFIPVFLTFFG 951

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtrNP_001246145.1 Patched 53..845 CDD:280598 252/810 (31%)
Sterol-sensing 295..442 CDD:289145 57/146 (39%)
PTCHD3NP_001382672.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..103
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154918
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H111041
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5641
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D210960at2759
OrthoFinder 1 1.000 - - FOG0001635
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR10796
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3619
SonicParanoid 1 1.000 - - X653
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.930

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