DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and SCAP

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_788277.1	Gene:	SCAP / 35529	FlyBaseID:	FBgn0033052	Length:	1276	Species:	Drosophila melanogaster

Alignment Length:	1178	Identity:	208/1178 - (17%)
Similarity:	383/1178 - (32%)	Gaps:	391/1178 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 REVFQELRQLDNIIQNATTTYDGDTYTYKDNCARWENECFENDILNLDALMDDIEA---GQLNLT 173
            |....|:.:|..|::|         :...:|....|:.|..         :|:::.   |||:..
  Fly   193 RAPLHEVFKLLEIVRN---------HQSSENKRTLEHNCLH---------VDNVKRGTHGQLDQI 239

  Fly   174 FP----FMFNPV----------TWDAHLFPVFFGGTKLTEDNYVISVPAIQLVY-FVTADT--KR 221
            ||    .:.:|.          |.|.::....|....|.:.    .|.|.:::: ....||  ||
  Fly   240 FPEYGCLLLSPANLWTQNSQNFTRDTNILNTIFQYHNLQKS----KVSAAEMLFGLPMQDTGFKR 300

  Fly   222 QDAKGAEWEETFLRVVGNAENSGQF------KHISVSYFASRTLDHEL---------------EK 265
            ...:...      |::       |:      ||..:.|.  .||..:|               |.
  Fly   301 YPLRARS------RII-------QYALTLFLKHNDMEYL--DTLKEKLLRHYPPLPLASASAEEP 350

  Fly   266 NTKT------------VVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFG 318
            .|.|            :||| :..|:|:..:...:....|..||:..|.|...::...:...:.|
  Fly   351 TTITYIFYPGEYRMWELVPY-TVAFMLVFAYVYFSVRKIDVFRSRFLLALCSVITTAGSLAMSLG 414

  Fly   319 LAMYCGIEFIGINLAA----PFLMIGIGIDDTFVMLAGWRRTKAKMPVAE------RMGLMMSEA 373
            |..:.|:.   |:|.:    |:|:|.:|::::.|:      ||:.:.:.|      |:...:|:.
  Fly   415 LCFFFGLT---ISLQSKDIFPYLVILVGLENSLVI------TKSVVSMDETFDVKIRVAQALSKE 470

  Fly   374 AVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYR-----ER 433
            ...|:.|.:|:.....||:.:....::.||.:::..:...|:..:..|:..:|::..|     |.
  Fly   471 GWHISKTLLTEITILTIGLATFVPVIQEFCIFAIVGLLSDFMLQMLLFSTILAMNIKRTEYTAEA 535

  Fly   434 KNL-HSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNP---IDNKDHMLMAF-----FKD 489
            |:| ..:..|   ......::.|.|       |...|..|..|   ..::.|..:.|     ..|
  Fly   536 KHLPKMLLSC---TQGAGRQDFRFF-------GAAPALPPFVPGTFQRSQSHPKLCFADPASVSD 590

  Fly   490 KMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERR-KLSREDSYSVEFFDREDDYYREFP 553
            : .:::|                     |.:..::.:.:| |:       |.|:.|...:.|.|.
  Fly   591 R-TSLVN---------------------GHSSPEQRIPKRIKI-------VNFWARTRFFQRAFM 626

  Fly   554 YRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDD 618
            ..|.|.|...:..|..|  ||:.::.|....|:.:..:|..::...:..||.|....       |
  Fly   627 IWMIVWICSIVYNSGYL--EQLFSMQSNGTMTATLELQRRLQAGRGAVSSFFEGWQA-------D 682

  Fly   619 EQTFIDAVKEHWLFPGNPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSP 683
            .|....|..      |:.||..::             ...|::|.:|  .:||:| ||....|..
  Fly   683 GQRATSAPS------GSGFSTPIK-------------APLAIDINET--AEEMMR-LRYPSFDLN 725

  Fly   684 LNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSL------------WVAF 736
            ...|.|| :.....|:.    :||....:..:..:.:|....|.:...|            |.|
  Fly   726 YFLSNFH-WSTIMKQYN----ISLSGHYVTLLPTIRLSHAIAPELATLLRNPQEQLQQNFQWKA- 784

  Fly   737 SVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSL 801
                    :|..:...|.|.|.:                          ::.||.....
  Fly   785 --------LAAALDPLDFNDDDV--------------------------RRESPMVMAE------ 809

  Fly   802 GLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCL---- 862
            |||::..|...|  ..|:||....||::.:.|   |:|:                   .|:
  Fly   810 GLPLVPKSPMEI--FFAILLCCISIFVLCYTM---VVFY-------------------RCICTRN 850

  Fly   863 ------TWTGKDDGSDAEVDDGLDDRQLEKPFSQS-------------YYMQYPSIGINGPYGSK 908
                  :|                 .:.|.|:.|:             :..:...:..:|.|...
  Fly   851 YAEWRSSW-----------------HESEAPYKQTEQILEGVPTQIAGHKHRIECLVSDGAYIIS 898

  Fly   909 GFLGAPYKAYGVDEKDLGLGTSGEDSSESSSSRSQHRQQAAATEEEVVVRE---SPTRRYDDGWR 970
            ..|....:.:.        ..|||..:..|.|..|..||  .|:.:.:||:   ||.      |.
  Fly   899 CCLKGQIRVWD--------ARSGEQLTSISRSDIQISQQ--RTDGQTLVRKLAVSPV------WC 947

  Fly   971 RSSYQNIYGQGAAQFQAQPDLYGKQVSATEWRQRLDTHEQQQRQRQRRSPFENYRQDVEIDMQKA 1035
            ...:.|:...|.|  ..:.:|:.......:..                     |::|       |
  Fly   948 LDYFDNLIAVGCA--NGRVELWESPAGLLKCA---------------------YQED-------A 982

  Fly  1036 RRNSHGDVIDLHGTPNSSVEERFRRRGEPFSAESGDDSSYRHQQIMAMPAAGSAPSAKRYHRRRS 1100
            :||.  .:..:|...:..:..|...|.:.:..|    :.|:.:||    ..|...:.:|.|.|..
  Fly   983 KRNQ--GITHIHLNGDRVIVARLNGRLDFYRLE----TYYKGKQI----DWGFTSAYRRTHVRTG 1037

  Fly  1101 SEDSTS---RHQRWPANIEERRAR-------RAYSPAHNRPETAL---TSYAYRSSSHHNL--YQ 1150
            |..|..   :.||......::..:       .....||.:|.|.:   ....:..|..|.|  |.
  Fly  1038 STGSLGLMLQQQRCQQEASQKTTKEEMKITLEGVRLAHQQPITCMQVVNDMVFTGSQDHTLKVYC 1102

  Fly  1151 PNGKSSKY 1158
            .|....:|
  Fly  1103 LNKSDVEY 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	152/822 (18%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	33/162 (20%)
SCAP	NP_788277.1	Sterol-sensing	390..542	CDD:289145	33/160 (21%)
		WD40	<878..1227	CDD:225201	51/289 (18%)
		WD40	878..1185	CDD:295369	51/289 (18%)
		WD40 repeat	887..942	CDD:293791	14/64 (22%)
		WD40 repeat	945..983	CDD:293791	7/73 (10%)
		WD40 repeat	989..1070	CDD:293791	15/88 (17%)
		WD40 repeat	1079..1114	CDD:293791	7/32 (22%)
		WD40 repeat	1120..1157	CDD:293791
		WD40 repeat	1162..1196	CDD:293791
		WD40 repeat	1201..1233	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460577
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840