Protein Alignment Ptr and Ptchd1

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001178663.1
• Gene: Ptchd1 / 317517
• RGDID: 1564527
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 878
• Identity: 246/878 - (28%)
• Similarity: 422/878 - (48%)
• Gaps: 67/878 - (7%)

  Fly    12 LNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYF 76
            |...|..||..||.||.:|...|||:::|....:.:.:.:...|:|.:|.....|.||.:|...|
  Rat    10 LRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIERNLVNSLF 74

  Fly    77 KVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDGDTYTYKD 141
            .||.:.......:..|||:||||| |.....||:.:.....:.:|...:........|..||:..
  Rat    75 PVNRSKHRLYSDLQTPGRYGRVIV-TSYQKANMLDQHHTDLILKLHTAVTKIQVPRPGFNYTFAH 138

  Fly   142 NCA-RWENECFENDILN-LDALMDDIEAGQLNLTFPFMFNPVT--------WDAHLFPVFFGGTK 196
            .|. ..:..|..:||:: |:.|.:.....:.|....:   |:|        ::.|.    .||..
  Rat   139 ICVLNNDKTCIVDDIVHVLEELKNARATNRTNFAITY---PITHLKDGRAVYNGHQ----LGGVT 196

  Fly   197 LTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDH 261
            :...:.|.|..||||.|::.:.....|.....||.:|...|...:.|.  ..:.:..:.|.:|..
  Rat   197 VHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVKLFQKSN--SKVKIYPYTSSSLRE 259

  Fly   262 ELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIE 326
            :.:|.::....|..::.:|:...:|:.|.|.|.|||||:|||:|.|:..:|||.|.|:....|.:
  Rat   260 DFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGK 324

  Fly   327 FIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIG 391
            :....|..||:|:|.|:..||.||:.||:|:....|.||...:.:::.:|.::|:....::|.||
  Rat   325 YNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIG 389

  Fly   392 IISPFRSV---RIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKE 453
             .|||.::   ||||..|..|:.|.:|:.::|:.:.:..:||.|....|||| ||..|....::|
  Rat   390 -ASPFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFTGYIENNYQHSIF-CRKVPKPEVLQE 452

  Fly   454 K---RNFLYKAIM----AGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASY 511
            |   ..||..|..    |.|.:||..::      |:|:.|.|......|.|.:.|..::|.:..|
  Rat   453 KPAWYRFLLTARFSEDTAEGEEANTYES------HLLVCFLKRYYCDWITNTYVKPFVVLFYLIY 511

  Fly   512 LVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVE 576
            :..|..|..|:.||.:...:....:.::|:......|:..:...:...|...:.|.:..|||.|
  Rat   512 ISFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKYFNNYSPVIGFYIYESIEYWNSSVQEDV- 575

  Fly   577 NLTSTLEHT-SYVTSRRYTESWLRSFLSFLERNNELLNVTVD-DEQTFIDAVKEHWL----FPGN 635
                 ||:| .:|..     ||..|:|::|.:    |||:.| .::.|.|.::..:|    |  :
  Rat   576 -----LEYTKGFVRI-----SWFESYLNYLRK----LNVSTDLPKKNFTDMLRNSFLKAPQF--S 624

  Fly   636 PFSLDVRFNE---DETQIIASRFLIQAVNITDTNHEK--EMVRDLRQICKDSPLNASIFHPYFVF 695
            .|..|:.|::   ||..::|||..:.|..: :||.|:  :::..||::...|.:...:|:|.||:
  Rat   625 HFQEDIIFSKKYNDEVDVVASRMFLVAKTM-ETNREELYDLLETLRRLSVTSKVKFIVFNPSFVY 688

  Fly   696 FDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSIS 760
            .|::.......|....|.|:.::..|...:.:.|.::|:..:|:|:|.||.|:|.||.|.||.||
  Rat   689 MDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWITLTVVSVEFGVIGFMTLWKVELDCIS 753

  Fly   761 MINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSY 825
            ::.||..|.:::|..|.:..|::..|..:....|:.||...|:.|:|.....|:|:..|....|.
  Rat   754 VLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLFPLAAVPSN 818

  Fly   826 IFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGP 858
            :....|:.:||:.|....|...:|||:|:...|
  Rat   819 LTCTLFRCLFLIAFVTFFHCFAILPVILTFLPP 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	227/822 (28%)
Ptchd1	NP_001178663.1	Patched	105..851	CDD:308203	213/780 (27%)