DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptch2

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_571063.2	Gene:	ptch2 / 30181	ZFINID:	ZDB-GENE-980526-44	Length:	1442	Species:	Danio rerio

Alignment Length:	1267	Identity:	242/1267 - (19%)
Similarity:	439/1267 - (34%)	Gaps:	407/1267 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 IQNATTTYDGDTYTYKDNCARWENECF--------ENDILNLDALMDDIEAGQLNLTFPFMFNPV 181
            :.|......|..:.:......|:.|..        :|.:.:.:||.          |...:.:|.
Zfish   299 VPNIAAELQGGCHGFSKKFMHWQEELILGERVKDSQNALQSAEALQ----------TMFLLMSPK 353

  Fly   182 TWDAHLFPVFFGGTKLTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNA--ENSG 244
            ....|.           :|:|.|        :.:..:..:..|....|:..|:.||..:  :||.
Zfish   354 QLYEHF-----------KDDYEI--------HDINWNEDKATAILESWQRKFVEVVHGSIPQNSS 399

  Fly   245 QFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSA 309
            .    :|..|::.||:..::..:...|...:..:|||..::.:|.:..|..:|:..:||.|.:..
Zfish   400 S----NVYAFSTTTLNDIMKSFSDVSVIRVAGGYLLMLAYACVTMLRWDCAKSQGAVGLAGVLLV 460

  Fly   310 IMATLAAFGLAMYCGIEFIGINLAA----PFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMM 370
            .::..|..||....|:.|   |.|.    |||.:|||:||.|::...:..|::.:|..||.|..:
Zfish   461 ALSVAAGLGLCSLLGLSF---NAATTQVLPFLALGIGVDDMFLLAHSFTETRSNIPFKERTGDCL 522

  Fly   371 SEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKN 435
            .....|:.:||:.:.|:|.:..:.|..::|.|...:...|.|.|...:..|.|.:::..:|....
Zfish   523 RRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDK 587

  Fly   436 LHSIFGC----------RVQPMSVAIKEKRNFLYKAIMAGGIDAND-----PDNP------IDNK 479
            ...|..|          ::||..::                 ||||     |..|      |...
Zfish   588 RLDILCCFYSPCSSRVIQIQPQELS-----------------DANDNHQRAPATPTYTGSTITTS 635

  Fly   480 DHM-------------------------------------------------------------- 482
            .|:
Zfish   636 THITTTVQAFTQCDAAGQHIVTILPPTSQISTTPPSMVLSTPTPTTDPYGSQVFTTSSSTRDLLA 700

  Fly   483 --------------------LMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLE 527
                                |.:|.::|.|.::.....|.::::.|.:.|..:.||.|.:.:||.
Zfish   701 QVEEPKEGRECVPLPFFRWNLSSFAREKYAPLLLKPETKTVVVVVFVALLSLSLYGTTMVHDGLY 765

  Fly   528 RRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTS-- 590
            ...:...|:...||...:..|: .| |.|.::.....:|:..  |.|:..|.:......||..
Zfish   766 LTDIVPRDTQEYEFITAQFKYF-SF-YNMYLVTMDGFDYARS--QRQLLQLHNAFNSVKYVVKDG 826

  Fly   591 --------RRYTESWLRSFLSFLERNNELLNVTVDDEQTFID-------------AVKEHWLFPG 634
                    ..|.:.||:...:..:.:.|...:|.|..:...:             :.||    |.
Zfish   827 NHKLPRMWLHYFQDWLKGLQATFDADWEAGKITYDSYRNGTEDGALAYKLLIQTGSKKE----PF 887

  Fly   635 NPFSLDVRFNEDETQIIASRFLIQAVNITDTN--------------HEKEMVRD--------LRQ 677
            |...|..|...||..:|........:.:..:|              |.:|.:.|        ||
Zfish   888 NYSQLTSRRLVDEDGLIPPEVFYIYLTVWVSNDPLGYAASQANFYPHPREWIHDKYDTTGENLR- 951

  Fly   678 ICKDSPLNASIFHPYFV--------FFDQFELVRPVSLQAM------------------------ 710
            |....||..:.| |:::        |.:..|.||.:..:.|
Zfish   952 IPAAEPLEFAQF-PFYLNGLRQASDFIEAIESVRTICEEFMRQGIKNYPNGYPFLFWEQYIGLRH 1015

  Fly   711 --VIGAIIMMIISFVFIPNILCSLWVA------FSVISIELGVAGYMALWDVNLDSISMINLIMC 767
              ::...:::..:|:....:|.:.|.|      .:::::||  .|.|.|..:.|.:|.::.||..
Zfish  1016 WFLLSISVVLACTFLVCAILLLNPWTAGVIVFILAMMTVEL--FGIMGLIGIKLSAIPVVILIAS 1078

  Fly   768 IGFSVDFTAHICYTYMSS-KKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQS---YIFL 828
            :|..|:||.||...:::: ..|:.::.|  |:..:..|:|.|:.||:||:  |:||.|   :|..
Zfish  1079 VGIGVEFTVHIALGFLTAIGDRNTRSAV--AMEHMFAPVIDGAISTLLGV--LMLAGSEFDFIMR 1139

  Fly   829 VFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCLTWTGKDDGSDAEVDDGLDDRQLEKPFSQSYY 893
            .||.::.::...|.::||.||||||||.||             .|||....:...|:.|..:.
Zfish  1140 YFFAVLAILTLLGILNGLVLLPVLLSLMGP-------------PAEVVPANNANHLQSPSPEP-- 1189

  Fly   894 MQYPSIGINGPYGSKGFL-GAPYKAYGVDEKDLGLGTSGEDSSESSSSRSQHRQQAAAT----EE 953
             ..|.:..:|.|.  |.: .|.::|:                  |.:|.|::..:...|    ||
Zfish  1190 -MPPPMNHHGYYA--GHIPKASHQAF------------------SETSDSEYYSETTTTSGIGEE 1233

  Fly   954 EVVVRESPTRRYDDGWRRSSYQNIYGQGAAQFQAQPDLYGKQVSATEWRQRLDTHEQQQRQRQRR 1018
            |.        :|.|   ||:|        ....|||.               .||...:..:...
Zfish  1234 EY--------KYCD---RSTY--------ITPPAQPP---------------TTHILLEASKNPS 1264

  Fly  1019 -------SPFENYRQDVEIDMQKARRNSHGDVIDLHGTPNSSVEERFRRRGEPFSAESGDDSSYR 1076
                   .||.      |:...:.::|:...:        ||..:|:..:.|        |...|
Zfish  1265 FPKLTVVKPFH------EVQNCETKQNAVNSI--------SSQIKRWDNKNE--------DQGQR 1307

  Fly  1077 HQQIMAMPAAGSAPSAKRYHRRRSSEDSTSRHQRWPANIEERRARRAYSPAHNRPETALTSYAYR 1141
            .|.:         |:.:...:||:::......|   ...:::....|::.|...|..|:|.....
Zfish  1308 RQHL---------PTDRTNCQRRTTQCGPGPQQ---GTGQQQNRTTAHTGALQHPNNAITMVTAT 1360

  Fly  1142 SS----SHHNLYQPNGKSSKYPPTYQYGDYYH 1169
            :|    .|.:|          |.:||  .|.|
Zfish  1361 ASVTVAVHPSL----------PGSYQ--GYMH 1380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	174/925 (19%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	40/150 (27%)
ptch2	NP_571063.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		2A060602	31..1182	CDD:273338	189/964 (20%)
		Sterol-sensing	445..595	CDD:289145	40/152 (26%)
		SLC5-6-like_sbd	<1004..>1151	CDD:294310	36/152 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930