DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and NPC1L1

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_037521.2	Gene:	NPC1L1 / 29881	HGNCID:	7898	Length:	1359	Species:	Homo sapiens

Alignment Length:	1040	Identity:	224/1040 - (21%)
Similarity:	405/1040 - (38%)	Gaps:	252/1040 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GISCVDK-------TLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPI 61
            |.|..||       .|.:.|...|..:|..|...:::.|:..:....|....:...||..|:|..
Human   322 GTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAP 386

  Fly    62 AGEGKTERAIVEQYFKVNYTHRFNVGRITRPG----RFGRVIVITK------DGDENMIRREVFQ 116
            ..:.::|:|..:|:|...:  |.|...:|.|.    |:..:::..|      |.|..:...|:.:
Human   387 NSQARSEKAFHDQHFGPFF--RTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQE 449

  Fly   117 ELRQLD--------NI-IQN-ATTTYDGDTYTYKDNCARWENECFEND--ILNLDALMDDIEAGQ 169
            .||.|.        || :|: .....:.|..:..|.|.....:.|:|:  :|.|.|
Human   450 RLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTA--------- 505

  Fly   170 LNLTFPFMFNPVTWDAHLF-------------------------PVF----FGGTK---LTEDNY 202
             |.|.....:.|.|..|..                         |||    .||.|   .:|...
Human   506 -NQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEA 569

  Fly   203 VISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAEN--SGQFKHISVSYFASRTLDHELEK 265
            :|.  ...|..:...|.:...||  .|||.||..:...:.  :|.|:   |::.|.|:|:.|:.:
Human   570 LIM--TFSLNNYPAGDPRLAQAK--LWEEAFLEEMRAFQRRMAGMFQ---VTFMAERSLEDEINR 627

  Fly   266 NTKTVVPYFSSTFLLMGLFSIITCMMGD-------AVRSKPFLGLMGNVSAIMATLAAFGLAMYC 323
            .|...:|.|::::::  :|..|:..:|.       .|.||..|||.|....:.|.:||.|...|.
Human   628 TTAEDLPIFATSYIV--IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYL 690

  Fly   324 GI-EFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAK--MPVAERMGLMMSEAAVSITITSVTDF 385
            || ..:.|....|||::.:|.|:.|:.:..::|...:  .|....:|..:...|.|:.:.|:::.
Human   691 GIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEA 755

  Fly   386 ISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVA 450
            |.|.:|.::|..:||.|...|..||...||..::.|.|.:::...|:..:...:. |.|:|..:.
Human   756 ICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVC-CCVKPQELP 819

  Fly   451 IKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGA 515
                                    |....:.:|:.||:...|..:.:...:.:::|.|.:....:
Human   820 ------------------------PPGQGEGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVS 860

  Fly   516 CYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPL--------NYSDPLVQ 572
            .|.:..|..||::.....:|||.:::|...:.|:.         :..|:        |:|.....
Human   861 LYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFE---------VGAPVYFVTTLGYNFSSEAGM 916

  Fly   573 EQV--------ENLTSTLEHTSYVTSRRY----TESWLRSFLSFLERN----------------- 608
            ..:        .:.|..:::.:....:.|    ..||:..|:.:|..:
Human   917 NAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYISGPNKDKFCP 981

  Fly   609 ---NEL------LNVTVDDEQTFIDAVKEH--WLFPGNP-----------FSLDVRFNED----E 647
               |.|      :::|:...:..::...::  |.....|           :|..|....|    :
Human   982 STVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLD 1046

  Fly   648 TQII----------------------ASRFLIQAVNITDTNHEKEMVR-----------DLRQIC 679
            |..|                      .|||:.....:.::....|.:|           |||::.
Human  1047 TVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVP 1111

  Fly   680 KDSPLNASIFHPYF---VFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCS---------- 731
            ...|  |....||.   ||::|:..:.|..|          .::|...:|....|
Human  1112 GTDP--AFEVFPYTITNVFYEQYLTILPEGL----------FMLSLCLVPTFAVSCLLLGLDLRS 1164

  Fly   732 -LWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVR 795
             |....|::.|.:...|:||||.::.:::|:|||:..:|.||:|.:||..::..|.|.:...|.:
Human  1165 GLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAK 1229

  Fly   796 EALHSLGLPIIQGSSSTIL-GIVALLLAQSYIF-LVFFKMVFLVIFFGAMHGLFLLPVLLSLFGP 858
            ||..|:|..:..|.:.|.| ||:.|.||::.:. :.||::..|:...|.:|||..|||:||..||
Human  1230 EATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGP 1294

Fly 859 858
Human 1295 1294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	203/969 (21%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	42/149 (28%)
NPC1L1	NP_037521.2	NPC1_N	31..283	CDD:293023
		2A060601	33..1293	CDD:273337	222/1037 (21%)
		Sterol-sensing	661..814	CDD:289145	43/153 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154915
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840