DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and Disp1

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_038946501.1	Gene:	Disp1 / 289338	RGDID:	1307675	Length:	1556	Species:	Rattus norvegicus

Alignment Length:	1054	Identity:	209/1054 - (19%)
Similarity:	379/1054 - (35%)	Gaps:	230/1054 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 TKLTEDNYVISVPAIQ--LVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASR 257
            |..|.|   .:|||::  :::..|       .||......:|   .|.||......|:.......
  Rat   470 TSKTAD---YAVPALKYSMLFSPT-------EKGESMMNIYL---DNFENWNSSDGITTVTGIEF 521

  Fly   258 TLDHELEKN---TKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGL 319
            .:.|.|.::   ..||.|..:...:|     :|.|:...:|    |:.||...:.|.:.:.::.|
  Rat   522 GIKHSLFQDYLLMDTVYPAIAIAIVL-----LIMCVYTKSV----FITLMTMFAIISSLIVSYFL 577

  Fly   320 -AMYCGIEFIG-INLAAPFLMIGIGIDDTFVMLAGWRRTKAKMP---VAERMGLMMSEAAVSITI 379
             .:....||.. :||.|..:::|||.||.||:...|..||:..|   .:|.:.:.:..||:|:.:
  Rat   578 YRVVFNFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKSDKPRAETSEAVSVTLQHAALSMFV 642

  Fly   380 TSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGC-- 442
            ||.|...:|....:|...::|.|..|:..|:...::..:|:..|.:.:    ..:.|.:||.|
  Rat   643 TSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HERYLLNIFTCFR 703

  Fly   443 RVQPM-------SVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVI---NN 497
            :.||.       :|..::.|..|:....|..|                  ||:..:..::   ..
  Rat   704 KPQPQAYHKSCWTVLCRKGRKALFAISEASRI------------------FFEKVLPCIVIKFRY 750

  Fly   498 KWCKAIIILAFASYLVGACYGI----------TQIKEGLERRKLSREDSYSVEF---FDREDDYY 549
            .|     ::.|.:..||..|.:          .::.|....|.....:.|..||   |..|..::
  Rat   751 LW-----LVWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEFKKLFMFERVHH 810

  Fly   550 REFPYRMQVIIAG--PLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELL 612
            .|..:....:|.|  |.:..|||..:....|  ||:.|..:.|.. :::|:..|...| ||....
  Rat   811 GEELHMPITVIWGVSPEDSGDPLNPKSKGEL--TLDSTFNIASPA-SQAWILHFCQKL-RNQTFF 871

  Fly   613 NVTVDDEQT--FIDAVKEHW----------LFP-----GNPFSLDV------------------- 641
            :.|...:.|  ||:..|: |          |:|     ..|:..:|
  Rat   872 HQTEQQDFTSCFIETFKQ-WMENQDCDEPALYPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYH 935

  Fly   642 --------RFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKD---------SPLNASIF 689
                    ||:.::| |.|.....|:..:....:||     ::|..|:         |.....:.
  Rat   936 LNNKTPGPRFDINDT-IRAVVLEFQSTFLFTLAYEK-----MQQFYKEVDSWISHELSSAPEGLS 994

  Fly   690 HPYFV----FFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMA 750
            |.:||    |:|..:.:...:|.||.:...:...:..:...||:.||:...|:........|.:.
  Rat   995 HGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLV 1059

  Fly   751 L--WDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTI 813
            |  |::|:  :..:.:.:.:|.||||..|....|..:.....:.:|..:|..:|..|...:.:|.
  Rat  1060 LLGWELNV--LESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLGRMGSAIAVAALTTF 1122

  Fly   814 LG--------IVALLLAQSYIFLVF-FKMVFLVIFFGAM---------HGLFLLPVLL--SLFGP 858
            :.        ::|.....:::.||. ....|...||..:         .|...||..|  |.|..
  Rat  1123 VAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFFFQCLCRCLGPQGTCGQIPLPKKLQCSAFSH 1187

  Fly   859 GSCLTWTGKDDGSDA---EVDDGLDDRQLEKPFSQSYYMQYPSIGINGPYGSKGFLGAPYKAY-- 918
            .|.....|:..|...   .||......:||   .:.|.:|        |.||.....:...||
  Rat  1188 TSAARPGGRAPGKATNAYSVDARGQKSELE---HELYELQ--------PLGSHSCTSSDMTAYEG 1241

  Fly   919 --------GVDEKDLGLGTSGEDSSESSSSRSQHRQQA---AATEEEVVVRES--PTRRYDDGWR 970
                    ....|:|.:..|...|||.:.|.......|   ...|::.:...|  |.....:.:.
  Rat  1242 PCICSEFFNGQAKNLRMPMSAAYSSELTKSPRSEPGSALLQPCLEQDTMCHFSLNPRCNCPNAYT 1306

  Fly   971 RSSYQNIYGQGAAQFQAQPDLYGKQVSATEWRQRLDTHEQQQRQRQRRSPF-------ENYRQDV 1028
            ...|            ..|:::.:|:..:...:...|.....:.:...:|.       |.....|
  Rat  1307 HRKY------------GLPEIHCQQMGDSLCHKCASTAGSFVQIQNAAAPLKATHHAAEGLLHPV 1359

  Fly  1029 EIDMQKARRNSHGDVIDLHGTPNSSVEERFRRRGEPFSAESGDDSSYRHQQIMAMPAAGSAPSAK 1093
            :..:....:||......||...:...:|..    .|.|....:::..|..:....|.||::.|::
  Rat  1360 QHMLPPGMQNSQSRNFFLHPVQHFQAQESL----GPTSTRGRENTDERPPRTAEPPPAGASRSSE 1420

  Fly  1094 RYHRRRSSEDSTSR 1107
            .:.|...:.::..|
  Rat  1421 SFQRACCNPENNQR 1434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	157/763 (21%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	40/151 (26%)
Disp1	XP_038946501.1	Patched	467..1147	CDD:355433	153/738 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348808
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840