Protein Alignment Ptr and Disp3

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001076811.1
• Gene: Disp3 / 242748
• MGIID: 2444403
• Length: 1347
• Species: Mus musculus
• Alignment Length: 1143
• Identity: 193/1143 - (16%)
• Similarity: 352/1143 - (30%)
• Gaps: 444/1143 - (38%)

  Fly    94 RFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDGDTYTYKDNCARWENECFENDILNL 158
            |...:.:...|.:.|:...|....:.:::..|.        |...:::.|  |:    .:::|.
Mouse   229 RIELIFLARGDAERNIFTSERLVTIHEIERKIM--------DHPGFREFC--WK----PHEVLK- 278

  Fly   159 DALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVFFGG----------------------------- 194
                 |:..|..:...|    |.:...:.||...||
Mouse   279 -----DLPLGSYSYCSP----PSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYW 334

  Fly   195 ---TKLTEDNYVISVPAIQLVY------FVTADTK--RQDAKGAEWEETFLRVVGNAENSGQFKH 248
               ..|:.||...|:...::::      :.:.|.:  .|.||...:..|::.::.....|    .
Mouse   335 YVDEGLSVDNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTS----K 395

  Fly   249 ISVSYFASRTLDHELEK--NTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIM 311
            :.|.|..:...|:|:.:  |...::.:.||:.:...::.:.:|.:        ||...|..|..:
Mouse   396 VQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSV--------FLSFFGIASIGL 452

  Fly   312 ATLAAFGLAMY---CGIEFIGI-NLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSE 372
            :.|.|  |.:|   .||:::|| |..|.|:::|||:||.||.:..:|:.........||...:..
Mouse   453 SCLVA--LFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTIQT 515

  Fly   373 AAVSITITSVTDFISFLIGIISP---------FRSVRIFCTYSVFAVCFTF-----LWHITFFA- 422
            |..:...||:|...::...:.|.         |.|:.:.|.:  .||.||.     ||.: :.|
Mouse   516 AGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVTCCW--LAVLFTMPAALGLWSL-YMAP 577

  Fly   423 -------ACMAISGYRERKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDP-------- 472
                   :|....|  .:.:||.       |..:....:|        |||..|..|
Mouse   578 LESSCQNSCHQKCG--RKSSLHF-------PGDLFTAPER--------AGGGPAQGPLPYLDDDI 625

  Fly   473 ------DNPID----------------------NKDHMLMAFFKDKMA-----AVINNKWC---- 500
                  |.|..                      |....|:|..::.:.     |.:.::|.
Mouse   626 PLLNVEDEPASLELGDVSLVSVHCEGLQPTPDANSRGQLLAQLQELLHHWVLWAAVKSRWVIVGL 690

  Fly   501 -KAIIILA--FASYLVGA--------------------------------CYGITQ--------- 521
             .:|:||:  |||.|..|                                |.|:.|
Mouse   691 FASILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNN 755

  Fly   522 IKEGLERRK------------LSREDSYSVEFFDREDDYYREFPYRM------------------ 556
            ::..||::|            .:.::|.|..:..:.........||:
Mouse   756 VRTSLEKKKRGSGVSWASRTETTAQESMSTVYISKVKSKGHPAVYRLSLNASLPAPWQAVSPGDG 820

  Fly   557 -----QVIIA----------------GPLNYSDPLVQEQVENL-----------------TSTLE 583
                 ||..|                |.|..:.|..:..|..|                 |...:
Mouse   821 EVPSFQVYRAPFGDFTKKLTACMSTVGLLQAASPSRKWMVTALACDARRGWKFDFSFYVATKEQQ 885

  Fly   584 HTS-------------------------------------YVTSRRYTESWLRSFLSF------- 604
            ||.                                     ||.|.:..::.:.:...|
Mouse   886 HTRKLYFAQSHKPPFHGRLCVAPPGCLLSSSPDGPTKGFFYVPSDKVPKARISATFGFNPCVNTG 950

  Fly   605 ------------------------LERNNELLNVTVDDEQTFI-----DAVKE--HW-------- 630
                                    |.|..::.|..:.|..:.|     |..||  |.
Mouse   951 CGKPAVRPLVDTGAMVFVVFGIIGLNRTQQMDNHVIGDPGSVIYDSSFDLFKEIGHLCRLCKAIA 1015

  Fly   631 --------------------------------------LFPGNPFSLDVRFNEDETQIIASRFLI 657
                                                  |.||......|...|...|.|:..|
Mouse  1016 GNSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVKEGRVQWISMAF-- 1078

  Fly   658 QAVNITDTNHE--------KEMVR---DLRQICKDSPLNASIFHPYFVFFDQFE--LVRPVSLQA 709
                 ..|.::        .:.:|   .|||..:..| ..|..|..|...:.::  .:..:.:|:
Mouse  1079 -----ESTTYKGKSSFQTYSDYLRWESFLRQQLQTFP-EGSALHRGFQTCEHWKQIFMEIIGVQS 1137

  Fly   710 MVIGAIIMMIISF----VFIPNILCSLWVAFSVISIELGVAG--YMALWDVNLDSISMINLIMCI 768
            .:.|.::.::|..    ||..::|..|.|..|::.|...|..  |.:.|:  :.::..|:|.:.:
Mouse  1138 ALYGLVLSLLICVAAVAVFTTHVLLLLPVLLSILGIVCLVVTIMYWSGWE--MGAVEAISLSILV 1200

  Fly   769 GFSVDFTAHICYTYMSSKKRSP-----------KARVREALHSLGLPIIQGSSSTILGIVALLLA 822
            |.|||:..|:...|:.:.:..|           :.|..||:..:|:.|:..:.:|::..|.|...
Mouse  1201 GSSVDYCVHLVEGYLLAGENLPPQQAEDPSSQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFC 1265

  Fly   823 QSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGS 860
            ....|..|.|:|.|......::.|.:...||.:..|||
Mouse  1266 IIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPGS 1303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	187/1126 (17%)
Disp3	NP_001076811.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	156..207
		MMPL	<386..>571	CDD:440656	46/200 (23%)
		MMPL	<1142..>1299	CDD:440656	36/158 (23%)