DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptr and Npc1l1

DIOPT Version :9

Sequence 1:NP_001246145.1 Gene:Ptr / 35546 FlyBaseID:FBgn0262867 Length:1169 Species:Drosophila melanogaster
Sequence 2:NP_997125.2 Gene:Npc1l1 / 237636 MGIID:2685089 Length:1333 Species:Mus musculus


Alignment Length:1061 Identity:226/1061 - (21%)
Similarity:421/1061 - (39%) Gaps:248/1061 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYF 76
            |.:.|...|..:|..|...:.:..::.:....|...::...||..|:|....:.:.|:|..:::|
Mouse   337 LGRFFESWGTRVASWPLTVLALSFIVVIALSVGLTFIELTTDPVELWSAPKSQARKEKAFHDEHF 401

  Fly    77 KVNYTHRFNVGRITRPGRFGRVIVITKD-----------GDEN---MIRREVFQELRQLDNIIQ- 126
            ...:             |..::.|..|:           |.:|   ::..::.|||.:|...:: 
Mouse   402 GPFF-------------RTNQIFVTAKNRSSYKYDSLLLGPKNFSGILSLDLLQELLELQERLRH 453

  Fly   127 -------------------------NATTTYDGDTYTYKDNCARWENECFENDILNLDALMDDIE 166
                                     |.:.|         |.|.....:.|:|:...|....:...
Mouse   454 LQVWSHEAQRNISLQDICYAPLKPHNTSLT---------DCCVNSLLQYFQNNHTLLLLTANQTL 509

  Fly   167 AGQLNLT-----FPFMFN-PVT--------------WDAHLFPVF----FGGTKLTEDNYVISVP 207
            .||.:|.     |.:..| |:|              :.|.:||..    :.||..:|      ..
Mouse   510 NGQTSLVDWKDHFLYCANAPLTYKDGTALALSCIADYGAPVFPFLAVGGYQGTDYSE------AE 568

  Fly   208 AIQLVYFVT---ADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHELEKNTKT 269
            |:.:.:.:.   ||..|. |....|||.||:.:.:.:.|...| ..:::.|.|:|:.|:.:.|..
Mouse   569 ALIITFSINNYPADDPRM-AHAKLWEEAFLKEMQSFQRSTADK-FQIAFSAERSLEDEINRTTIQ 631

  Fly   270 VVPYFSSTFLLMGLFSIITCMMGD-------AVRSKPFLGLMGNVSAIMATLAAFGLAMYCGI-E 326
            .:|.|:.::|::.|:  |:..:|.       ||.||..|||.|....:.|.:||.|...|.|: .
Mouse   632 DLPVFAISYLIVFLY--ISLALGSYSRWSRVAVDSKATLGLGGVAVVLGAVVAAMGFYSYLGVPS 694

  Fly   327 FIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAER---MGLMMSEAAVSITITSVTDFISF 388
            .:.|....|||::.:|.|:.|:.:..::|. .:||..:|   :|..:...|.|:.:.|:::.|.|
Mouse   695 SLVIIQVVPFLVLAVGADNIFIFVLEYQRL-PRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICF 758

  Fly   389 LIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKE 453
            .:|.::...:||.|...|..|:.|.||..:|.|.|.:::...|:..:         :|..|....
Mouse   759 FLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKRQEAS---------RPDVVCCFS 814

  Fly   454 KRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYG 518
            .||.                .|...|:.:|:.||:......:.:::.:.:::|.|........|.
Mouse   815 SRNL----------------PPPKQKEGLLLCFFRKIYTPFLLHRFIRPVVLLLFLVLFGANLYL 863

  Fly   519 ITQIKEGLERRKLSREDSYSVE---------------FFDREDDYYREFPYRMQVII--AGPLNY 566
            :..|..||::.....:|||.::               :||....|.......|..|.  ||..::
Mouse   864 MCNISVGLDQDLALPKDSYLIDYFLFLNRYLEVGPPVYFDTTSGYNFSTEAGMNAICSSAGCESF 928

  Fly   567 SDPLVQEQVENLTSTLEHTSYVTSRRY----TESWLRSFLSFLERNNELLNVTV----DDE---- 619
            |          ||..:::.|...::.|    ..||:..|:.:|..::....:..    .||    
Mouse   929 S----------LTQKIQYASEFPNQSYVAIAASSWVDDFIDWLTPSSSCCRIYTRGPHKDEFCPS 983

  Fly   620 -QTFIDAVKE----------------H----WLFPGNP-----------FSLDVRFNEDETQIIA 652
             .|..:.:|.                |    |.....|           :...|..:.| .||||
Mouse   984 TDTSFNCLKNCMNRTLGPVRPTTEQFHKYLPWFLNDTPNIRCPKGGLAAYRTSVNLSSD-GQIIA 1047

  Fly   653 SRFLIQAVNITDTNHEKEMVR-----------DLRQICKDSPLNASIFHPYF---VFFDQFELVR 703
            |:|:.....:.::....|.:|           :||::....| |..:| ||.   ||:.|:..|.
Mouse  1048 SQFMAYHKPLRNSQDFTEALRASRLLAANITAELRKVPGTDP-NFEVF-PYTISNVFYQQYLTVL 1110

  Fly   704 PVSLQAMVIGAIIMMIISFVFIP-NILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMC 767
            |..:..:.:..:...::.::.:. :|...:....|:|.|.:...|.||:|.::.:::|:|||:..
Mouse  1111 PEGIFTLALCFVPTFVVCYLLLGLDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTA 1175

  Fly   768 IGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSST-ILGIVALLLAQSYIF-LVF 830
            :|.||:|.:||..::..|.|.:...|.::|...:|..:..|.:.| ..||:.|..||:.:. :.|
Mouse  1176 VGMSVEFVSHITRSFAVSTKPTRLERAKDATIFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFF 1240

  Fly   831 FKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCLTWTGKDDGSDAEVDDGLDDR------QLEKPFS 889
            |::..|:...|.:|||..|||:||..||          |.:.|.|   |:::      .:.:|..
Mouse  1241 FRLNLLITLLGLLHGLVFLPVVLSYLGP----------DVNQALV---LEEKLATEAAMVSEPSC 1292

  Fly   890 QSYYMQYPSIGINGPYGSKGF 910
            ..|  .:|:......|.:.||
Mouse  1293 PQY--PFPADANTSDYVNYGF 1311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtrNP_001246145.1 Patched 53..845 CDD:280598 200/947 (21%)
Sterol-sensing 295..442 CDD:289145 43/150 (29%)
Npc1l1NP_997125.2 NPC1_N 30..283 CDD:293023
2A060601 32..1267 CDD:273337 214/1000 (21%)
Sterol-sensing 684..815 CDD:289145 35/140 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845385
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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