DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and Ptchd1

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001087219.1	Gene:	Ptchd1 / 211612	MGIID:	2685233	Length:	888	Species:	Mus musculus

Alignment Length:	878	Identity:	246/878 - (28%)
Similarity:	422/878 - (48%)	Gaps:	67/878 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYF 76
            |...|..||..||.||.:|...|||:::|....:.:.:.:...|:|.:|.....|.||.:|...|
Mouse    10 LRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIERNLVNSLF 74

  Fly    77 KVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDGDTYTYKD 141
            .||.:.......:..|||:||||| |.....||:.:.....:.:|...:........|..||:..
Mouse    75 PVNRSKHRLYSDLQTPGRYGRVIV-TSYQKANMLDQHHTDLILKLHTAVTKIQVPRPGFNYTFAH 138

  Fly   142 NCA-RWENECFENDILN-LDALMDDIEAGQLNLTFPFMFNPVT--------WDAHLFPVFFGGTK 196
            .|. ..:..|..:||:: |:.|.:.....:.|....:   |:|        ::.|.    .||..
Mouse   139 ICVLNNDKTCIVDDIVHVLEELKNARATNRTNFAITY---PITHLKDGRAVYNGHQ----LGGVT 196

  Fly   197 LTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDH 261
            :...:.|.|..||||.|::.:.....|.....||.:|...|...:.|.  ..:.:..:.|.:|..
Mouse   197 VHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVKLFQKSN--SKVKIYPYTSSSLRE 259

  Fly   262 ELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIE 326
            :.:|.::....|..::.:|:...:|:.|.|.|.|||||:|||:|.|:..:|||.|.|:....|.:
Mouse   260 DFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGK 324

  Fly   327 FIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIG 391
            :....|..||:|:|.|:..||.||:.||:|:....|.||...:.:::.:|.::|:....::|.||
Mouse   325 YNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIG 389

  Fly   392 IISPFRSV---RIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKE 453
             .|||.::   ||||..|..|:.|.:|:.::|:.:.:..:||.|....|||| ||..|....::|
Mouse   390 -ASPFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFTGYIENNYQHSIF-CRKVPKPDVLQE 452

  Fly   454 K---RNFLYKAIM----AGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASY 511
            |   ..||..|..    |.|.:||..::      |:|:.|.|......|.|.:.|..::|.:..|
Mouse   453 KPAWYRFLLTARFSEETAEGEEANTYES------HLLVCFLKRYYCDWITNTYVKPFVVLFYLIY 511

  Fly   512 LVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVE 576
            :..|..|..|:.||.:...:....:.::|:......|:..:...:...|...:.|.:..|||.|
Mouse   512 ISFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKYFNNYSPVIGFYIYESIEYWNSSVQEDV- 575

  Fly   577 NLTSTLEHT-SYVTSRRYTESWLRSFLSFLERNNELLNVTVD-DEQTFIDAVKEHWL----FPGN 635
                 ||:| .:|..     ||..|:|::|.:    |||:.| .::.|.|.::..:|    |  :
Mouse   576 -----LEYTKGFVRI-----SWFESYLNYLRK----LNVSTDLPKKNFTDMLRNSFLKTPQF--S 624

  Fly   636 PFSLDVRFNE---DETQIIASRFLIQAVNITDTNHEK--EMVRDLRQICKDSPLNASIFHPYFVF 695
            .|..|:.|::   ||..::|||..:.|..: :||.|:  :::..||::...|.:...:|:|.||:
Mouse   625 HFQEDIIFSKKYNDEVDVVASRMFLVAKTM-ETNREELYDLLETLRRLSVTSKVKFIVFNPSFVY 688

  Fly   696 FDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSIS 760
            .|::.......|....|.|:.::..|...:.:.|.::|:..:|:|:|.||.|:|.||.|.||.||
Mouse   689 MDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWITLTVVSVEFGVIGFMTLWKVELDCIS 753

  Fly   761 MINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSY 825
            ::.||..|.:::|..|.:..|::..|..:....|:.||...|:.|:|.....|:|:..|....|.
Mouse   754 VLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLFPLAAVPSN 818

  Fly   826 IFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGP 858
            :....|:.:||:.|....|...:|||:|:...|
Mouse   819 LTCTLFRCLFLIAFVTFFHCFAILPVILTFLPP 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	227/822 (28%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	56/149 (38%)
Ptchd1	NP_001087219.1	Patched	105..851	CDD:355433	213/780 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845384
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.810