Protein Alignment Ptr and ptr-21

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_490751.1
• Gene: ptr-21 / 191752
• WormBaseID: WBGene00004235
• Length: 909
• Species: Caenorhabditis elegans
• Alignment Length: 978
• Identity: 237/978 - (24%)
• Similarity: 414/978 - (42%)
• Gaps: 185/978 - (18%)

  Fly     6 SCVDKTLNKSFYHLG------------IC---IAKHPGYFIIIPVLLTLLCMTGY----QQLKYQ 51
            |...:..:|:|..||            :|   |.:.|..|||..|   ::|..|.    .:||..
 Worm    18 SATSRPRHKTFELLGPVNNISLADMYKVCGKIIGRFPIAFIIATV---IMCSGGLGTIGLELKDN 79

  Fly    52 IDPEYLFSPIAGEGKTERAIVEQYFKVNYTHRFNVGRITRPGR--FGRVIVITKDGDENMIRREV 114
            :...|  :|.....:.|..:..::             ::..|.  ...|::..|||. :|.|.:.
 Worm    80 VRDGY--TPKNSLSRLENRLYREF-------------LSSEGDPVMTTVLMTAKDGG-SMHRIKY 128

  Fly   115 FQEL-RQLDNIIQNATTTY-DGDTYTYKDNCARWENECFENDILN--LDALM-----DDIEAGQL 170
            .:|. ||...|.:|.:... :|:...:.|.|..:   |..|||:.  |||..     ..::..||
 Worm   129 LEEAQRQWLYISKNLSADVGNGEFMKFGDFCGHY---CQANDIIGYFLDAYKTKSADPKMDGYQL 190

  Fly   171 NLTFPFMFNPVT----WDAHLFPVFFGGTKLTED--NYVISVPAIQLVYFVTADTKRQDAKGAEW 229
            |.       |:|    :..||...|||.|....|  ..:.|:..:.|.......|.....|..:|
 Worm   191 NY-------PITTVMGYQLHLERNFFGVTVNQSDPVTNIQSMKVLTLPVLSEVRTFEDTDKLNKW 248

  Fly   230 E-ETFLRVVGNAENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGD 293
            | ..:....|.:...|....:.::...:..:|.|:.|:.:.:||||     ::|:.|:|..:...
 Worm   249 ELAVYNYATGYSALEGDDHLVEINVIGAEVVDTEMNKDAQKMVPYF-----IVGIVSMIIFIFCT 308

  Fly   294 AVRSKPFLGL----MGNVS------AIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFV 348
            ...|..:.|.    :|.::      .|:|.|.|||:....|.......:..|||:.|||::|.|:
 Worm   309 VSISASYYGYFSWRIGLIALACLLVPILAILTAFGINNMLGNRTNSPMMIMPFLINGIGVNDAFL 373

  Fly   349 MLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFT 413
            .|..|.:....:|..:|:|.|::||..|||.|::|:.|.||||.::|...:.|||.....::...
 Worm   374 TLQNWLQHSPDLPSGKRLGYMLAEAGPSITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLA 438

  Fly   414 FLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDN 478
            :::.:|||.                       |:.|.:..:|             .|:| :.::.
 Worm   439 YVYTLTFFC-----------------------PVLVLLLSER-------------VNEP-SKLEG 466

  Fly   479 KDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKL------SREDSY 537
            ..:.::.|:    |.:|.::|..|::|:....|.....||...|:..|...|:      .|:.:.
 Worm   467 TFNKVLGFY----AKIICSRWTFALLIIGSLVYWGFGIYGTLGIRAVLNTAKILPLETPIRKPNR 527

  Fly   538 SVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFL 602
            .:     |:..::|| |.:.||:..|::.|:.......:||....|.........||.|.:|.:.
 Worm   528 II-----EETVWKEF-YPVTVIVNSPVDISNANALRAFDNLVHDFESMEKCRGSEYTISPIRDYQ 586

  Fly   603 SFLERNNELLNVTVDDEQTFIDAVK--EHWL-------FPGNPF------SLDVRFNEDETQIIA 652
            ::      ...|..:|.....:.||  .|.|       |..||.      .|.:.|: :...|..
 Worm   587 TY------FYGVGAEDFDYEEETVKNTSHSLDFSKLTGFLANPIYKHHKGGLKLNFS-NPVPIRK 644

  Fly   653 SRFLIQAVNITDTNHEKEMVRDLRQICKDS-PLNASIFHPYFVFFDQFELVRPVSLQAMVIGAII 716
            .:.:....|:|..:...::::|.|.|.... .||.|:::...:|.||...::.:::...::....
 Worm   645 VQLIFAYENVTSWDERIQIMQDWRTIASSHVALNVSVWNVNAMFVDQMLSLKGLAISNALVTLGC 709

  Fly   717 MMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYT 781
            |..:..|||.|.|.......|::||.:||.||:..||::||.:::..:|:.||.||||.||:...
 Worm   710 MAAVCVVFIRNPLSVGLATASILSISIGVTGYLCFWDLDLDPVTLCAVIVSIGMSVDFVAHVACH 774

  Fly   782 YMSSKK-------------RSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKM 833
            |....|             ::|::||..:|.::..|::|.:|||:|.::.|.:.|:|:.:||.|.
 Worm   775 YQVRYKEFEEKGVLKRIEMKTPESRVVNSLSNVLWPMVQSASSTLLCVLPLGILQNYLPMVFVKT 839

  Fly   834 VFLVIFFGAMHGLFLLPVLLSLFGPGSCLTWTGKD------------DGSDAEVDDGLDDRQLEK 886
            :.||:.:|..|||.|||.:|:.| |.|....|..|            ..||:|.|.|  |.|...
 Worm   840 ILLVVIWGMFHGLVLLPCILAQF-PLSVFNKTFADLLFGRTSSSSCSSESDSETDTG--DAQEMV 901

  Fly   887 PFS 889
            |.:
 Worm   902 PLA 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	201/854 (24%)
ptr-21	NP_490751.1	Patched	83..863	CDD:308203	209/865 (24%)