DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptr-19

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001255085.1	Gene:	ptr-19 / 191751	WormBaseID:	WBGene00004233	Length:	1003	Species:	Caenorhabditis elegans

Alignment Length:	1088	Identity:	288/1088 - (26%)
Similarity:	499/1088 - (45%)	Gaps:	162/1088 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGY--QQLKYQIDPEYLFSPIAGEGKTER 69
            |::|....:|......:.:||..|.|||:|:|....||.  .:..:..|...|::|...:.:.|.
Worm     5 CIEKRFAHAFGAYSGVVVRHPFPFFIIPILITAGLSTGLLRHEQAFMKDELELYTPTDAQARKEL 69

  Fly    70 AIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDG 134
            :.::..|.:|.:..|...|.....|.|.:||..::.|.:::...|.....||.:|:|:.|...:.
Worm    70 SQLDHLFHINDSDPFYATRRYDIRRAGYIIVTNQEEDGDILNPLVMHSAMQLWSIVQSLTVEDED 134

  Fly   135 D-TYTYKDNCARW---------------------ENECFENDILNLDALMDDIEAGQLN-----L 172
            | ...|...|.::                     |..|..|.::.:..|:...:...||     :
Worm   135 DRRINYPSICVKFPIPPEFSKALHSLFAPNMTTPEEICVSNPLVEIFKLLLVSDRSFLNRSIDEM 199

  Fly   173 TFPFMFNPVTWDAHLFPVFFGGTKLTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVV 237
            |...:.:.:.:|:.......||..|.:|..:....|:.|.|.:...:..:|....:||      |
Worm   200 TLSQISDAIQFDSGGMTHLLGGVTLDDDKRIAGAKAMLLPYALRHSSDDEDWVAEKWE------V 258

  Fly   238 GNAENSGQFKH--ISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPF 300
            ..|:...|:..  |..|::...||..|..::...::......|:.:.:|:|..|.:....||:|:
Worm   259 RLADFLLQYDSPIIRASWWTYETLAAESARDRLQLIHMLLPCFVCVSIFTIACCCVFSWRRSRPW 323

  Fly   301 LGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAER 365
            |.:.|.:||.||..:|.|:.:..|.....:..:.||::..:|:|:.|::|:.||.|.:...:..|
Worm   324 LAIGGVISAAMAIASAVGILLLAGYGMTSVAYSMPFIVFSVGVDNVFILLSAWRSTSSTETLEHR 388

  Fly   366 MGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGY 430
            |....::||||||:||:||.|||.:|..:||.||::||.|:|.||.||:::.:|||||.|..:..
Worm   389 MKETFADAAVSITVTSLTDLISFGVGCATPFPSVQMFCAYAVAAVIFTYIYQLTFFAAVMVYTNR 453

  Fly   431 RERKNLHSIFGCRVQ----PMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKM 491
            ||..|.|.||..:::    |..:|.:..|:|                    .|:.:|..||:...
Worm   454 REINNRHCIFFHKLKKDTLPEKIAAQGDRSF--------------------EKNTILAQFFRTTY 498

  Fly   492 AAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREF---- 552
            :..:.|...:.:|::.|..||..|.||.|::|.|||...|..|:||........:.|:.::
Worm   499 SDFLLNPLVRIVILVTFCVYLGVASYGCTKVKLGLEPNDLLPENSYGKRTLMMAEKYFSDYGSSL 563

  Fly   553 ---PYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNV 614
               .|.:..:...|....: :::::||    ..|||.:..|   ::||||:||:|:::...|:.
Worm   564 HVWMYNLSEVDVAPRKIWN-VLEKEVE----LYEHTEFTAS---SDSWLRTFLAFVKQAGLLIT- 619

  Fly   615 TVDDEQTFIDAVKEHWLFPGNP----FSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDL 675
                .:.|:..:|.  :|...|    ::.||...||...:.|||..:|..::...|..:.| |..
Worm   620 ----PENFVYILKN--VFLSQPQFAKYNRDVVLTEDGEHLEASRIPVQLRHVGSANQSRAM-RLF 677

  Fly   676 RQICKDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVIS 740
            |::.:.|.|...::..:|.|.:|:..|.|.:|.::....:.::.:|.:.||..:.||||:||::|
Worm   678 RRLAETSELQTGVYADFFQFAEQYNAVLPGTLSSIAYAGVAVVAVSLILIPEPVASLWVSFSIVS 742

  Fly   741 IELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPI 805
            |.:|:.|:|..|.|.||.|||:.::|.|||.|||.||:.|.:...:......|:|.||:::|.||
Worm   743 INIGILGFMTFWSVRLDFISMVTIVMSIGFCVDFAAHLAYNFAKGQNMDGSERMRNALYAVGAPI 807

  Fly   806 IQGSSSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCLTWTGKDDG 870
            :..::|||:|:..:..|:||:|..|.|.:.|||..||:|||.:||||||:|..|          |
Worm   808 LMSATSTIIGVSFMASAESYVFRSFLKTIMLVILLGALHGLVILPVLLSMFYCG----------G 862

  Fly   871 SDAEVDDGLD--DRQLEKPFSQS------YYMQYPSIGINGPYGSKGF--------------LGA 913
            |..:..:.:|  |::|:..::..      .::..|.:....|..|..:              |||
Worm   863 SSKKAKEHIDAVDQKLQAQYNNPARTASIQFLSNPDLYTMPPPPSVEYSLSTLEFNRTQSRPLGA 927

  Fly   914 PYKAYGVDEKDLGLGTSGEDSSESSSSRSQHRQQAAATEEEVVVRESPTRRYDDGWRRSSYQNIY 978
            |....|..:::|. |.||....|      :|               .||
Worm   928 PPALTGSPKRELS-GLSGPPEYE------EH---------------DPT---------------- 954

  Fly   979 GQGAAQFQAQPDLYGKQVSATEWRQRL--DTHEQQQRQRQRRSPFENY 1024
              |.:.|...|.:..........|.:|  .:...|:|..:.||..|.|
Worm   955 --GLSTFGVSPAVVANTTGMIPMRAKLKYPSSMTQRRDSESRSTPELY 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	232/835 (28%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	61/146 (42%)
ptr-19	NP_001255085.1	Patched	53..858	CDD:355433	241/846 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H111041
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28777
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	1	1.000	-	-		FOG0001635
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102973
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X653
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930