DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptr-15

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_504760.1	Gene:	ptr-15 / 191749	WormBaseID:	WBGene00004229	Length:	840	Species:	Caenorhabditis elegans

Alignment Length:	879	Identity:	223/879 - (25%)
Similarity:	398/879 - (45%)	Gaps:	108/879 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYFKVNY 80
            ||..|:.|...|.:|.:.|::||::...|...::.:.|..:|:||       |.::..:.::|
Worm    20 FYQYGLFIYDRPRFFTLGPLILTIIFSFGILNMRTEDDLRFLYSP-------EHSLSREEYQV-- 75

  Fly    81 THRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDN-IIQNATTTYDGDTYTY-KDNC 143
             |:...|. ::...|..:.:.|...|:|::::::.|:|.||:. :::......||....: |:.|
Worm    76 -HKDFSGD-SKNNSFVSITIQTSSEDKNLLKKDLAQKLIQLNKYVLEKMEIQVDGKIINFGKEVC 138

  Fly   144 ARWENECFENDILNL-------DALMDDIEAGQLNLTFP---FMFNPVTWDAHLFPVFFGGTKLT 198
            :|.:.....|.|..:       :.|..|   .::.:.:|   |..|......|.:.|..||.
Worm   139 SRMKQCELSNTIATIFLDTFWSEKLRKD---PRIKIEYPTMKFFDNKFFLPTHFYGVQPGGP--- 197

  Fly   199 EDNYVISVPAIQLVYFV------TADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASR 257
                 :.:.:|.:|:||      ...|..:.:|..|...|.|     .||...|   ..|.|:..
Worm   198 -----LGIESIDMVHFVYQIPAYNEHTSEEMSKIFEQSLTAL-----LENQTTF---DTSMFSLS 249

  Fly   258 TLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMY 322
            .|..|::||:...:|:.|.|.||:..|::.:||..:.|.|||...::|.:.:.||.::|.||...
Worm   250 ILKDEMQKNSTYTMPFISLTILLLLCFTVASCMTDNWVTSKPIEAMIGILVSSMAIVSAGGLLFA 314

  Fly   323 CGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFIS 387
            .|:.||......||:.:.||:||.:|||..|:.|:..:...:||||.:.||..:||:||:|..:|
Worm   315 LGVPFINQVTVMPFIALAIGVDDVYVMLGAWQDTRRTLDAKKRMGLALEEAGSAITVTSLTSVLS 379

  Fly   388 FLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIF---GCRVQPMSV 449
            |.||..|...::.|||.:...|:.|.:.:.:|||||.||:...||....|.:|   .|..:.::.
Worm   380 FGIGTYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAMGAKREAAGYHCVFVWKRCDREEIAK 444

  Fly   450 AIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVG 514
            |..|              :|..|..          .||::..|..|.....:..::..:..|:..
Worm   445 AKNE--------------NAISPTR----------YFFENIFAPFICRPSVRFCMLNLYVVYIAI 485

  Fly   515 ACYGITQIKEGLERRKLSREDSYSVEFFD-REDDYYREFPYRMQVIIAGPLNYSDPLVQEQVENL 578
            |.||.:|:...|...:|..:||..|.:.: .|...:.|.......:...|....:|.:.:::..:
Worm   486 AFYGCSQLTPNLTPSQLVVDDSPLVPYLNLAEKKIWAEGLIGRIYVNNAPDFSKNPEMVDRMLQM 550

  Fly   579 TSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKEHWLFPGNPFSLDVRF 643
            .:.||.|.|......|..||..|       |........::..|.:.:|..         |.|.|
Worm   551 VNELESTPYSMGPNSTNFWLNEF-------NNYRQFFFQEDAKFYETLKSF---------LKVSF 599

  Fly   644 NED-ETQII-------------ASRFLI-QAVNITDTNHEKEMVRDLRQICKDSP-LNASIFHPY 692
            |.. ||.::             ..:|:. .|..|::.|....::...|.|....| .:|.:|...
Worm   600 NSHWETDLVWDTPDKSSKGGTKVEKFVFTTAFKISNWNIRTSLLLTWRNITSSYPEFDALVFDEN 664

  Fly   693 FVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLD 757
            ..:.||...::...|.::....|::..|..:||.......||..::||:::|.||.::||..:||
Worm   665 NFYSDQMLELQSTILSSLGTAIILLSAICIMFIAESYIVFWVVCTLISMDIGTAGLLSLWGADLD 729

  Fly   758 SISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLA 822
            .::::|::|.||..:||..|:......|:...|..|:|:|:.::|.|::|..:||:|.||.:|:.
Worm   730 PMTVVNILMSIGQCIDFATHVGIRIYRSEYSDPDERIRDAMGAIGWPVVQAGTSTLLAIVVMLMV 794

  Fly   823 QSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLF 856
            .|....:|.:...||:..|..|||.:||:::..|
Worm   795 PSSAVRMFARTSVLVVGTGFFHGLIILPIIVRSF 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	207/829 (25%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	56/149 (38%)
ptr-15	NP_504760.1	Patched	44..830	CDD:308203	214/855 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	1	1.000	-	-		FOG0001635
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880