DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptr-13

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_496392.2	Gene:	ptr-13 / 191748	WormBaseID:	WBGene00004227	Length:	851	Species:	Caenorhabditis elegans

Alignment Length:	915	Identity:	209/915 - (22%)
Similarity:	378/915 - (41%)	Gaps:	188/915 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LNKSFYHLGICIAKHPG--YFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQ 74
            :|...|:||    .||.  .|.:..||:.||.......|:.:.|....|:...|..      ||:
Worm    22 MNWISYYLG----NHPRCVLFSVFCVLIPLLSYFVIYPLEIECDIRRGFANKHGHA------VEE 76

  Fly    75 YFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENM-IRREVFQELRQLDNIIQNATTTYDGDTYT 138
            ..|.:..:..:||.:...|    |:...|..|.:: |..::..|:.||...:.|.||.|..:|..
Worm    77 LTKFSNFYNISVGGLEIWG----VLARNKTTDTDLHINLKLLNEIDQLHQFVWNYTTQYKQETIR 137

  Fly   139 YKDNCARWENECFE--NDILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVFFGGT------ 195
            :||..:...|..|.  ..:|.::.:..      :||::|..      :|...|.:.|..
Worm   138 FKDLSSEDINYVFNYYRKLLAIEWMPG------VNLSYPLA------EAFGHPFYLGNQFFGVNN 190

  Fly   196 -KLTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTL 259
             :.::...:.:...:.|.|...|:|..|..|....:....:......|:.||   ....|..:..
Worm   191 GQASKAGPIKTAKFVALWYMSKAETFEQKQKLQAVQLGIFKKSAERPNNLQF---DFEMFGDQVA 252

  Fly   260 DHELEKNTKTVVPYF-----------SSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMAT 313
            :.|:.:.|.|.|..|           :.||..:.:||  .||:        ..|.:|  |.:.||
Worm   253 NSEMLRGTLTTVKLFFIGGCLMVAFMACTFTELTIFS--KCML--------IAGAIG--SPLAAT 305

  Fly   314 LAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAE----RMGLMMSEAA 374
            .|.|.:..:.|..|..|....|||::|||:||.|::|..|||.:.|...|:    ::..::.|.:
Worm   306 GACFAILGWVGHPFNSIMCITPFLILGIGVDDAFLLLNCWRREEGKDKSAKQAENQLARVIREIS 370

  Fly   375 VSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSI 439
            .|:.|||:|:.::|.:|.::|...:..||..:..|:...||.....|..||.:. |:::
Worm   371 PSMAITSLTNTMAFGVGFLAPTPQMSSFCLGTALAIVLDFLLEFLIFVPCMVLF-YKKK------ 428

  Fly   440 FGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKW----- 499
                  |..:|| |...|           ||:.               .:|.:.....|:
Worm   429 ------PEIIAI-ENEEF-----------ANEK---------------TEKRSETSTGKYSRINW 460

  Fly   500 -C----------KAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVE----FFDREDDYY 549
             |          :.::|:.:.|....:.:|:.::::..:..|....||..|:    |...:.:|
Worm   461 KCFTNLLLSVPGRVLVIILYFSIFTASYFGVAKMEKTFDPSKTFPSDSKLVDSLASFTSIQVEY- 524

  Fly   550 REFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTE---------SWLRSFLSFL 605
                        .|||:...:  ..::|.|........:....:.|         :..|.::.||
Worm   525 ------------SPLNFLSSV--PDLKNDTDVANFNEMLHKLEFREECYGDVGSHNMYRDYVQFL 575

  Fly   606 ERNNELLNVTVDDEQTF--------IDAVKEHWLFPGNPFSLD-VRFNEDETQIIA----SRFLI 657
            ..:| :.:.:.:..:.|        :..:|.|  ..||...:| :.|      ::.    .::..
Worm   576 NYSN-ITDKSYNHLEKFLKGRGMADVGTIKYH--KEGNDTIIDMINF------VVVCQGREKWAE 631

  Fly   658 QAVNITDTNHEKEMVRDLRQICKD-SPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIIS 721
            :|||:..|          |||..| |..|.::|......:|....|:...::::.|....|.|..
Worm   632 RAVNVEKT----------RQILVDYSDYNITLFDYDGTIYDLIITVKGELVKSLAITFTCMTIAC 686

  Fly   722 FVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSK 786
            ||.:|:.:.....:.:.:||...:.|::::|..|||.::||::||.||||||::||:||.|..::
Worm   687 FVIMPSFVAPTIASVATVSISFCLIGFLSIWGQNLDPVTMIDVIMAIGFSVDYSAHVCYHYYCAR 751

  Fly   787 KR---SPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFL 848
            ::   |....:...|.::|.|:::.|.:|:|.:..|.:...|:...|.|.|.||..||.:||||.
Worm   752 EQHLGSKHEVITSVLQAVGRPVVEASLTTLLCMAPLFVVPVYMIQSFAKTVTLVTSFGLLHGLFF 816

  Fly   849 LPVLL 853
            |||:|
Worm   817 LPVVL 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	189/862 (22%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	43/150 (29%)
ptr-13	NP_496392.2	Patched	112..821	CDD:355433	183/809 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880