Protein Alignment Ptr and ptr-9

DIOPT Version :9

• Sequence 1: NP_001246145.1
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_499030.2
• Gene: ptr-9 / 191747
• WormBaseID: WBGene00004223
• Length: 844
• Species: Caenorhabditis elegans
• Alignment Length: 890
• Identity: 233/890 - (26%)
• Similarity: 415/890 - (46%)
• Gaps: 111/890 - (12%)

  Fly    10 KTLN------KSFYHLGICIAKHPGYFIIIPVLLTL----LCMTGYQQLKYQIDPEYLFSPIAGE 64
            |:||      :.|.:....:.:.|..|||||.|||.    |.:|.: .|....|...:|.|  .:
 Worm     2 KSLNFQSVVSQFFEYESTVVVRWPLPFIIIPPLLTFSIVTLTVTNF-HLNVTNDTLQVFLP--DD 63

  Fly    65 GKTERAIVE--QYFKVNYTHR--FNVGRITRPGRFGRVIVIT----KDGDENMIRREVFQELRQL 121
            .::.|.:.|  :.|......|  :::        ||...|.|    ...|.|::.....|.:.:|
 Worm    64 MRSLRDLKELLRLFPPRDAQRDTYSI--------FGSKFVYTVIEDDSSDGNILSSSGIQRMSKL 120

  Fly   122 DNIIQNATTTYDGDTYTYKDNCARWENE--CFENDILNLDALMDDIE--AGQLNLTFP-FMFNPV 181
            ...:....|:. ||...  .||.|.:::  |..:.|  ..||.|...  |.|..|.:| ..|...
 Worm   121 HKFVMGLETSL-GDNVA--SNCLRNKDDEACTMHPI--AFALEDTTPEFAIQFLLRYPNLKFGDF 180

  Fly   182 TWDAHLFPVFFGGTKL---TED----NYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGN 239
            ..|.   .:.||..::   ::|    :.:.|..|:::.|.:.:....:     .|.:.||..:..
 Worm   181 VIDN---AMVFGDVRIEPKSQDRDGNSPIRSSKAVRMTYILESSESTE-----RWIDLFLSAIPR 237

  Fly   240 AENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLM 304
            .:.:..    ::.:.:|::|..|:|:|.:.::|:...|.|::.:|.:..|...:.|:|:||:|..
 Worm   238 YKETNS----TIFWSSSKSLAKEMERNGELLIPWMPWTSLVLVVFCMFACSSLNIVKSQPFIGFF 298

  Fly   305 GNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLM 369
            ...:|.|||:|:..|.:|....|:.:....|||::.||.|:.|:||..||.||......:|....
 Worm   299 AMFNATMATIASTSLLLYLQYPFLPLVFIMPFLVVSIGTDNMFLMLKSWRMTKKSSNEEQRYIHA 363

  Fly   370 MSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERK 434
            ::|:|.|:.:||:||.:||.||.||.|.:||:||||...|:.|.||:.:|||.|.|::...||..
 Worm   364 LTESAASLFLTSLTDGLSFAIGSISDFHAVRVFCTYCAMAILFMFLFQVTFFNAVMSLCCRREVS 428

  Fly   435 NLHSIFGCR--VQPMSVAIKEKR-NFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVIN 496
            ..|.:|.|.  ..|....:.||: ||.:.:|:|               .|:    ||     ::|
 Worm   429 GKHPVFCCYEITPPEETQVLEKQSNFDFSSIVA---------------KHL----FK-----ILN 469

  Fly   497 NKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREF-PYRMQVII 560
            ....:..:...|.:||..:.:....:..||:.:.|:.:|||..:..:.::..:.:: .:...::.
 Worm   470 PLPSRIGVFFIFLAYLFISIHFAIGLPLGLDLKLLAPDDSYVSKELEAQERLFADYGGFCFALVR 534

  Fly   561 AGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVT----VDDEQT 621
            |..::..||:|:..:..|...|..:.|.:.   :|.||..|    |:.|.....:    .|:..|
 Worm   535 AENISLKDPMVRRNLIGLYRDLGGSEYSSP---SEFWLDPF----EKKNRGKKYSESDFSDELHT 592

  Fly   622 FIDAVKEHWLFPGNPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSPLNA 686
            |:  .||    |...|..|:||.. ..:|.|.:.:.:...:...| :......:|::.::|..|.
 Worm   593 FL--AKE----PHLKFRNDIRFTM-MGKIEAMKMMFRVRKLGKDN-DAPRAEYMRKVMENSQFNG 649

  Fly   687 SIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMI-ISFVFIPNILCSLWVAFSVISIELGVAGYMA 750
            .::...|:..|| ::....::...|:.||:.|: |..:.:|..:.::.:||:::|:.:||.|.:|
 Worm   650 FVYDTSFLLVDQ-QMTTVYNVIVDVVSAILTMLSICVLMVPRPVSAMCIAFAILSVNIGVIGALA 713

  Fly   751 LWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILG 815
            ..:..||.||||.::|.:|||||:..|..:.::..:..    |:.:.|..:..||:|.:.||.:|
 Worm   714 ATNTRLDIISMITIVMSVGFSVDYVTHTTFHFVIQRDN----RLEKCLLVMTEPILQSALSTAIG 774

  Fly   816 IVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGS 860
            :..|....|||...|...||.|:..|.:|||..|||||....|.|
 Worm   775 VSLLSFVHSYIVRTFVNTVFFVVGLGILHGLIFLPVLLDTIVPDS 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	207/820 (25%)
		Sterol-sensing	295..442	CDD:289145	60/146 (41%)
ptr-9	NP_499030.2	Patched	52..817	CDD:280598	215/835 (26%)
		Sterol-sensing	288..439	CDD:289145	61/150 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	1	1.000	-	-		FOG0001635
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880