DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptr-1

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_505380.1	Gene:	ptr-1 / 191746	WormBaseID:	WBGene00004216	Length:	956	Species:	Caenorhabditis elegans

Alignment Length:	948	Identity:	269/948 - (28%)
Similarity:	445/948 - (46%)	Gaps:	126/948 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ISCVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQI--DPEYLFSPIAGEGKT 67
            :|..|..::|.|:.:|..:.|...||:::...:......|:.....|.  ||:|:|||.....:.
Worm     1 MSWFDDKIHKVFFRVGENVHKFRLYFLLLSFAILTFSAFGFLWFTEQTTNDPQYVFSPANAPWRY 65

  Fly    68 ERAIVEQYFKVNYTHRFNVGRITRPGR----FGRVIVITKD------GDENMIRREVFQELRQL- 121
            |||::.:::.:: ..:|      .||:    .|.|.||...      |..|::......|:.::
Worm    66 ERAVLTEHWPLD-EEKF------WPGKSYDLHGYVDVIASGRIHPDYGRPNILNIRYLDEVARIN 123

  Fly   122 DNIIQNATTTYD--GDTY--TYKDNCARWENECFENDILNL--------------DALMDDIEAG 168
            |.||.|.|...|  |..|  .|.|.|.|::..|:.||.:.:              ..|..||...
Worm   124 DYIIHNLTVPVDINGKHYDIAYTDLCMRYDWACYLNDHITMLMPKTRWGNFSGPFAELASDIINT 188

  Fly   169 QLNLTFPFMFNPVTWDAHLFPVFFGG-----TKLTEDNYVISVPAIQLVYFVTADTK--RQDAKG 226
            |:|:|:     |:.|.. ..|::||.     ..:.|:.:.....||:|.|    :|:  :.|..|
Worm   189 QVNITY-----PIGWRG-TEPIYFGALVGAPNLVDEEGHFDYASAIRLTY----NTREGKVDQYG 243

  Fly   227 AEWEETFLRVVGNAENS-GQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITC- 289
            .||.......:.:.||. .:.....|::  :.||...|:....|:.|.|..|..::..||.:..
Worm   244 IEWRRKLSMWLTDKENPVSELLEFGVNH--NMTLPEGLQDVADTLAPKFVGTCAILFTFSFLVSV 306

  Fly   290 ---------MMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDD 345
                     :|.|.|||||.:...|.::.||||:.:|||.::||..:..|...:|||::.|||||
Worm   307 VLRKHRTGQVMPDWVRSKPLVAAAGLMTPIMATVTSFGLILWCGFLYNAIVNVSPFLILCIGIDD 371

  Fly   346 TFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAV 410
            .|:|.|.|.||..:....:|:|..:|||||:|:|||:||..:|.:|..:....|::||.|:....
Worm   372 LFIMCAEWHRTNPQHSPEKRIGKTLSEAAVAISITSLTDIATFAMGCYTTLPGVQMFCMYTCVQC 436

  Fly   411 CFTFLWHITFFAACMAISGYRERKNLHSIF----------------------------------G 441
            .|.:::.|.|....:|.:...|:...|.:.                                  .
Worm   437 FFCYVYQIIFLGPVLAYAAEMEQNGQHVLLIRKAVDPDKTESPVKLWLLSGSVNRQDQEARRRNS 501

  Fly   442 CRVQPMSVAIKEKRNF---LYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVI---NNKWC 500
            .:|.|:....::|..|   :.|  :...::.:|.|...::::.::...|::.:...|   :.:.|
Worm   502 RKVAPVEKEGEKKSKFGEVVEK--LEHTLEKHDDDPGHNSEETLVSKVFREIIGPFILQKSTQVC 564

  Fly   501 KAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLN 565
            ..::.|.:.|..:|.|   ..|||||:.:.|.||..|..:|::..|:.:.....:|||::..|.:
Worm   565 ALLLYLVYISLAIGGC---LNIKEGLDPKLLVRESFYLSKFYEIIDETFWREGLQMQVVVNNPPD 626

  Fly   566 YSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKEHW 630
            ...|..::..:.:.:..|:|.|......|..|||::...||.....||:...:...........|
Worm   627 LFTPETRKGFDEMMAEFENTQYTMHPNATMIWLRAYEHHLETEVHELNIEKPNSTVEWYTRCRDW 691

  Fly   631 LFPGNP---FSLDVRFN----EDETQIIASRFLIQAVNI---TDTNHEKEMVRDLRQICKDSPLN 685
            |.....   :.:|:.:.    |:..:|.|.||.:...|.   ||..|..:::|.:..  |.|..|
Worm   692 LIVAGGRRLWQMDMVWANTTFEETPRITAFRFQLGLRNYRTPTDHTHSCKLMRSIAD--KYSMFN 754

  Fly   686 ASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMA 750
            .:.||.|:.|.||:..:.|...|.|:.....:..:|:|.||.::|::.:..|:.||.:||.|:|:
Worm   755 VTTFHEYYPFADQYLELTPSLFQNMISDLCTIFAVSWVMIPELICAVAIVLSIASINVGVLGFMS 819

  Fly   751 LWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILG 815
            .|.|||||:|:|.:|||||||||.:|||.|.:..|...| .||...||.:||.|:..|:|||:||
Worm   820 FWGVNLDSVSIITVIMCIGFSVDLSAHIAYAFSQSYGNS-HARAVAALETLGWPVFLGASSTVLG 883

  Fly   816 IVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLL 853
            |:.|.|..|||..:|||.|||||.|..:|||..||:.|
Worm   884 ILLLTLVDSYIVQIFFKTVFLVINFSILHGLIFLPIFL 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	253/888 (28%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	55/180 (31%)
ptr-1	NP_505380.1	Patched	47..926	CDD:308203	260/902 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28777
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	1	1.000	-	-		FOG0001635
OrthoInspector	1	1.000	-	-		otm14195
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.790