DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptr-5

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_510810.3	Gene:	ptr-5 / 181764	WormBaseID:	WBGene00004220	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	946	Identity:	219/946 - (23%)
Similarity:	396/946 - (41%)	Gaps:	173/946 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQ-LKYQIDPEYLFSPIAGEGKTERAIVEQ 74
            :|.:.||.:|..:.::|..::|:..|:::..:..|:. ||.:|...|  :|.....:.|..::.:
Worm    55 SLRRMFYLVGYSVGRYPHAYLIVAFLISINSLGMYRMVLKDRIRDGY--TPTNAPSRYETDVLRE 117

  Fly    75 YFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNA-TTTYDGDTYT 138
            ::.::......:           :|::.|:| .:|..:....|..:|.....|. ..:.||.|..
Worm   118 FYNISGDPAMTI-----------MILMPKNG-TSMHAKANLDEAEKLSKFFFNEFNASRDGRTLR 170

  Fly   139 YKDNCARWENECFENDILNLDALMDDIE----------AGQLNLTFPFMFNPVTWDAHLFPVFFG 193
            :...|   |..|..|.:.:|.....|.:          :...||::| :.....:|.||....||
Worm   171 FSQLC---EPYCQINKVFDLYKSAYDEQYKLFTTERRISKSSNLSYP-LATMSGFDIHLERSLFG 231

  Fly   194 ----------GTKLTEDN-----YVISVPAIQLVYFV----------TADTKRQDAKGAEWEETF 233
                      .||||..:     .:.::..::::.|:          ..|..|.:....||
Worm   232 VELNPKTEENTTKLTTSDMPPHRIITNMKHVEVIVFIFRGDRDSADKEKDLSRWELDAYEW---- 292

  Fly   234 LRVVGNAENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTF----LLMGLFSIITCMMGDA 294
                  :.|..:...:.|....:..||:|:.|:.:.:.|:|::.|    ..:.|..|:|.:..:.
Worm   293 ------SLNEHKSDIVEVQIVGTDVLDNEMMKDGRRLTPFFAAGFGFEITFVSLCVILTAVYHNC 351

  Fly   295 V-RSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGW---RR 355
            : :.|..:.|...:..|:|..:.:|:....|:......|..|||::|||:|..|:|:..|   ||
Worm   352 LDQGKLLISLGAVLCPILAITSTYGIVSILGMRTNSFMLVMPFLVMGIGVDSCFLMIHSWQKERR 416

  Fly   356 TKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITF 420
            .:|. ....|:|::......||||||:|||:||.||.::|....|:||..|..|:..|::..:..
Worm   417 AQAS-GTGNRLGMVYESVGPSITITSLTDFLSFAIGALAPTPETRLFCIASSIALALTYILQLVL 480

  Fly   421 FAACMAISGYRERKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMA 485
            |...:|::...|.|.. :...|..:....|..:|...:|
Worm   481 FGPILAVATRYEHKTT-TTSNCNWRKWLKACWKKCINVY-------------------------- 518

  Fly   486 FFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDRED---- 546
                  ..:::||:...:::|..|.|...|.||:..:|..|:..|:..:||.    ..|.:
Worm   519 ------CKILSNKFFAVVVMLGTAIYWYFAIYGLMTMKTRLDAVKILPKDSP----LQRPNLVLT 573

  Fly   547 -----DYYREFPYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLE 606
                 :|     :.:.::|..||:..:....::..|:....|.......:..|.||||.::.| .
Worm   574 NLVWANY-----HPVTILINAPLDLENRHQMDRYWNMVDEFEKMHNCKGKASTLSWLRDYIKF-S 632

  Fly   607 RNNELLNV-------------TVDDEQTFIDAVK----------EHWLFPGNPFSLDVRFNEDET 648
            .:.|..|:             .||..|..|...|          :||    :.|   :.::.:|.
Worm   633 YHGEPFNLFAFFGLMTPEVYEEVDPYQANITTAKLPEFLKSPFFKHW----DSF---IHYHYEEG 690

  Fly   649 QIIASRFLIQAV--NITDTNHEKEMVRDLRQICKD-SPLNASIFHPYFVFFDQFELVRPVSLQAM 710
            .|...||::...  |.:..:...:::.|.|::..: |.||.:::.|..:|.||...:...:.|..
Worm   691 VIKLDRFMMNVAYDNTSSWDTRIQLMTDWRKVANNYSDLNVTVWEPNGMFVDQMLSLGRTATQTG 755

  Fly   711 VIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFT 775
            :...:.|.::..:||||....:....|:.||..||.|:::||..:||.:.|..::|.||.||||.
Worm   756 IWTLVCMAVVCAIFIPNPCSIITATVSIASITTGVMGFLSLWSFDLDPVVMAAVLMSIGLSVDFI 820

  Fly   776 AHICYTYMSS----------KKRSPKARVREALHSLGL---PIIQGSSSTILGIVALLLAQSYIF 827
            ||:.|.:..:          ||...|.......|:||.   |:||...|||..|:.||...||..
Worm   821 AHVAYHFQLAHRKEIRNGKIKKIPLKGSTERLEHTLGAVAWPMIQAGVSTICCILPLLFRASYSP 885

  Fly   828 LVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCLT 863
            .||...:|||:.||.:|||.:||..|:.. |.|..|
Worm   886 SVFVAAIFLVVTFGMLHGLLILPTFLAAL-PESVTT 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	199/883 (23%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	46/150 (31%)
ptr-5	NP_510810.3	Patched	92..915	CDD:355433	208/902 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880