DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptr and ptr-24

DIOPT Version :9

Sequence 1:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001257219.1	Gene:	ptr-24 / 181456	WormBaseID:	WBGene00004238	Length:	892	Species:	Caenorhabditis elegans

Alignment Length:	944	Identity:	182/944 - (19%)
Similarity:	331/944 - (35%)	Gaps:	209/944 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTCGISCVDKT--------LNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGY----QQLKYQID 53
            ||..:..|.|:        |..|..|||..:...|..:|.:.:.:.:...|..    .:.::..|
Worm    50 MTVAVENVKKSAKIGKKMILGPSLGHLGSIVGSRPWLWITLSLFIGIASFTTLIIKPPKKEFGFD 114

  Fly    54 PEYLFS--PIAGEGKTERAIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQ 116
            ..|..|  |...|.|.:|..            |..|:...|. :..:....::.:::|.:...:.
Worm   115 TGYTTSDAPSIREMKAQRDF------------FTGGKKGTPW-YQALFFEPRNNEKSMHKGREYD 166

  Fly   117 ELRQLDNIIQNATTTYD---GDTYTYKDNCARWENECFENDILNLDALMDDIEAGQLNLTFPFMF 178
            |::|....::|....||   ....||.|.|.   :.|..|::|                     |
Worm   167 EMKQFYRTVKNMIIRYDETLEKNITYYDLCG---STCDLNELL---------------------F 207

  Fly   179 NPVT---WDAHLFPV--FFG----------GTKLTEDNYVISVPAIQLVYFVTADTKRQDAKGAE 228
            ..||   |....:|:  .||          ..:.:|....:|.....|||....:||...|....
Worm   208 TTVTMSFWSGLTYPIASIFGYESNIGKHFYEIETSETGEFLSAKKAMLVYMAFYETKHVKADLKL 272

  Fly   229 WEETFLRVVGNAENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFS-----STFLLMGL---FS 285
            :||.....| :..|:.:...:.|:....|.:...:|...|....|..     |.|:|.|:   ||
Worm   273 YEELMQNAV-DVHNANKDNSVIVTLHGERGMSIAVEAGMKHAFNYLGFGVLLSLFVLFGVLFFFS 336

  Fly   286 IITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVML 350
            .:.|..  .:....||.::..::.|::.:.:|.:..:.|.....:.:..|||.:..|.....::.
Worm   337 RLFCQF--TIFRIVFLWIVAIIAPILSFITSFAIYNFFGYSITPLIIFTPFLALIHGYYTVIMLT 399

  Fly   351 AGW------RRTKAKMPVAERMGLMM------SEAAVSITITSVTDF-----ISFLIGIISPFRS 398
            ..|      ||......:.|.....|      :..|:::.:.||...     :|.|:|:|..|..
Worm   400 HTWLSDSELRRDSRDEHLLEVFATCMPSLIVTASPAIALLLCSVYPIENYGAVSILLGLIMTFDI 464

  Fly   399 VRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKEKRNFLYKAIM 463
            |     :::|           ||:..|.|.             |..|..|......:..:...:.
Worm   465 V-----FAIF-----------FFSPFMLII-------------CPTQDFSPLPTNSKKIVKTTLK 500

  Fly   464 AGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILA--FASYLVGACYGITQIKEGL 526
            :           ::|        .:|.....::......|:.:|  .|..::....|.|.::..|
Worm   501 S-----------VEN--------MRDYYCNYVDKSLLVEIVAVAGIIALLIIPVYKGCTSVEGNL 546

  Fly   527 ERRKLSREDS-----------------YSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQ 574
            :.|:|.::||                 :|:.||                 :..|.|:|:.....:
Worm   547 DYRQLLKQDSNRNHGVHLMSDVVWPTWFSIMFF-----------------VNKPPNFSNVREYGR 594

  Fly   575 VENLTSTLEHTSYVTSRRYTESWLRSFLSFL--ERNNELLNVTVDDEQTFI-DAVKEHWLFPGNP 636
            .:::.:.::.............|:..|..|.  :..::.||:|  ..::|| ||:.:.|. .|..
Worm   595 FKSMMAEIDAIENKLPNNTDMVWINDFCRFTNSKPTDDALNMT--RFKSFIEDAIYKSWK-DGVK 656

  Fly   637 FSLDVRFNEDETQIIASRFLIQAVNITDTNHEK-EMVRDLRQICKDSP-LNASIFHPYFVFFDQF 699
            |.    |..|...:|.|...|.:...|.:..:| ::....|.:....| ...:.|.....|.|
Worm   657 FI----FLNDTHPVITSMLHIVSFEKTTSLADKAKLFEKCRAVTNKYPEFKTTPFDTEIGFAD-- 715

  Fly   700 ELVRPVSLQAMVI---GAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISM 761
             ::..|.|...||   |.:.|.|:|.:.|.|:..::....:|..:.....|.::|:||.::..:.
Worm   716 -IILQVPLVVAVIPLVGTVAMFIVSTIIIGNLSVAVLNFIAVCILYASTIGTVSLYDVTINPFNA 779

  Fly   762 INLIMCIGFSVDFTAHICYTY---MSSKKRSPKA-RVREALHSLGLPIIQGSSSTILGIVALLLA 822
            ...::....:...|.|.||.|   |..|.|:.|. |:.|.|.....|.|.....:|...|..:..
Worm   780 AFFLIIAALAPSCTTHYCYYYQQAMRIKLRAKKVDRMNEMLRKCFFPCIASVICSIAVFVPTMFC 844

  Fly   823 QSYIF--LVFFKMVF----LVIFFGAMHGLFLLP 850
            ...||  :.|...||    :||.|.....|.:||
Worm   845 HINIFESVAFTNNVFCLLGIVIAFFVQVMLNMLP 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	167/873 (19%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	28/163 (17%)
ptr-24	NP_001257219.1	Patched	117..841	CDD:355433	158/838 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010